Intenalization of antibodies by endothelial cells via fibronectin implicating a novel mechanism in lupus nephritis

Kidney International

Volumn 64, Issue 5, 2003, Pages 1662-1670

  Fujii, Hiroshi ^b   Nakatani, Kimihiko ^b   Arita, Norimasa ^b   Ito, Mitsuko R ^b   Terada, Miho ^b   Miyazaki, Tatsuhiko ^b   Yoshida, Minako ^b   Ono, Masao ^b   Fujiwara, Takashi ^b   Saiga, Kan ^b   Ota, Toshiyuki ^b   Ohtani, Haruo ^b   Lockwood, Martin ^b   Sasaki, Takeshi ^b   Nose, Masato ^a  

^a EHIME UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b NONE

Author keywords

HUVEC; Integrin; Lupus nephritis; MRL mice; Subendothelial deposition

Indexed keywords

ACTIN; ANTIBODY; ARGINYLGLYCYLASPARTYLSERINE; BETA1 INTEGRIN MONOCLONAL ANTIBODY; FIBRONECTIN; FIBRONECTIN MONOCLONAL ANTIBODY; MONOCLONAL ANTIBODY; TETRAPEPTIDE; UNCLASSIFIED DRUG;

ACTIN POLYMERIZATION; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIGEN ANTIBODY REACTION; ANTIGEN SPECIFICITY; ARTICLE; CELL CLONE; CELL CULTURE; CONTROLLED STUDY; CYTOPLASM; ELECTRON; ELECTRON MICROSCOPY; ENDOTHELIUM CELL; FLOW CYTOMETRY; FLUORESCENCE MICROSCOPY; GLOMERULOPATHY; GLOMERULUS; HYBRIDOMA; IN VITRO STUDY; INHIBITION KINETICS; INJECTION; INTERNALIZATION; LUPUS ERYTHEMATOSUS NEPHRITIS; MICROSCOPY; MOUSE; MOUSE STRAIN; NONHUMAN; PRIORITY JOURNAL; UMBILICAL VEIN; VASCULAR ENDOTHELIUM; ANIMAL; CYTOLOGY; IMMUNOLOGY; METABOLISM; MOUSE MUTANT; MURPHY ROTHS LARGE LYMPHOPROLIFERATIVE MOUSE; PROTEIN BINDING;

ANIMALS; ANTIBODIES, MONOCLONAL; ENDOTHELIAL CELLS; ENDOTHELIUM, VASCULAR; FIBRONECTINS; HYBRIDOMAS; KIDNEY GLOMERULUS; LUPUS NEPHRITIS; MICE; MICE, INBRED MRL LPR; MICE, SCID; PROTEIN BINDING; UMBILICAL VEINS;

EID: 0142249404     PISSN: 00852538     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1523-1755.2003.00252.x     Document Type: Article

References (33)

1. THEOFILOPOULOS AN, DIXON FJ: Murine models of systemic lupus erythematosus. Adv Immunol 37:269-390, 1985
2. ITO MR, TERASAKI S, ITOH J, et al: Rheumatic diseases in an MRL strain of mice with a deficit in the functional Fas ligand. Arthritis Rheum 40:1054-1063, 1997
3. CHURG J, BERNSTEIN J, GLASSOCK RJ: Lupus nephritis, in Renal Disease: Classification and Atlas of Glomerular Disease, Tokyo Igaku-shoin, 1995, pp 151-177
4. FOSTER MH: Nephritogenic properties of lupus autoantibodies, in Lupus Nephritis, edited by LEWIS EJ, Oxford, Oxford University Press, 1999, pp 22-78
5. TAKAHASHI S, NOSE M, SASAKI J, et al: IgG3 production in MRL/lpr mice is responsible for development of lupus nephritis. J Immunol 147:515-519, 1991
6. ITOH J, NOSE M, TAKAHASHI S, et al: Induction of different types of glomerulonephritis by monoclonal antibodies derived from an MRL/lpr lupus mouse. Am J Pathol 143:1436-1443, 1993
7. NOSE M, ITO MR, ONO M, et al: Vascular lesions in mice with a deficit in Fas-mediated apoptosis and their transfer. Int J Cardiol 54:S35-S44, 1996
8. VERCELLOTTI GM, LUSSENHOP D, PETERSON PK, et al: Bacterial adherence to fibronectin and endothelial cells: A possible mechanism for bacterial tissue tropism. J Lab Clin Med 103:34-43, 1984
9. HAMILL RJ, VANN JM, PROCTOR RA, et al: Phagocytosis of Staphylococcus aureus by cultured bovine aortic endothelial cells: Model for postadherence events in endovascular infections. Infect Immun 54:833-836, 1986
10. SINHA B, FRANCOIS PP, NUSSE O, et al: Fibronectin-binding protein acts as Staphylococcus aureus invasin via fibronectin bridging to integrin alpha5beta1. Cell Microbiol 1:101-117, 1999
11. LOWY FD: Is Staphylococcus aureus an intracellular pathogen? Trends Microbiol 8:341-343, 2000
12. ANDERSON B, RUCKER M, ENTWISTLE R, et al: Plasma fibronectin is a component of cryoglobulins from patients with connective tissue and other diseases. Ann Rheum Dis 40:50-54, 1981
13. LEVO Y: Presence of fibronectin in cold precipitates of patients with cryoimmunoglobulinemia. Int Arch Allergy Appl Immunol 68: 179-181, 1982
14. VILLAR M, GARCIA-BRAGADO F, JOVEN J, et al: Cryoglobulinemia and fibronectin. Acta Haematol 74:161-163, 1985
15. PIERSCHBACHER MD, RUOSLAHTI E: Cell attachment activity of fibronectin can be duplicated by small synthetic fragments of the molecule. Nature 309:30-33, 1984
16. HUMPHRIES MJ, AKIYAMA SK, KOMORIYA A, et al: Identification of an alternatively spliced site in human plasma fibronectin that mediates cell type-specific adhesion. J Cell Biol 103:2637-2647, 1986
17. MOULD AP, KOMORIYA A, YAMADA KM, HUMPHRIES MJ: The CS5 peptide is a second site in the IIICS region of fibronectin recognized by the integrin alpha 4 beta 1. Inhibition of alpha 4 beta 1 function by RGD peptide homologues. J Biol Chem 266:3579-3585, 1986
18. KOMORIYA A, GREEN LJ, MERVIC M, et al: The minimal essential sequence for a major cell type-specific adhesion site (CS1) within the alternatively spliced type III connecting segment domain of fibronectin is leucine-aspartic acid-valine. J Biol Chem 266:15075-15079, 1991
19. MCDONALD JA, QUADE BJ, BROEKELMANN TJ, et al: Fibronectin's cell-adhesive domain and an amino-terminal matrix assembly domain participate in its assembly into fibroblast pericellular matrix. J Biol Chem 262:2957-2967, 1987
20. SANCHEZ-APARICIO P, DOMINGUEZ-JIMENEZ C, GARCIA-PARDO A: Activation of the alpha 4 beta 1 integrin through the beta 1 subunit induces recognition of the RGDS sequence in fibronectin. J Cell Biol 126:271-279, 1994
21. HORMANN H: Fibronectin - Mediator between cells and connective tissue. Klin Wochenschr 60:1265-1277, 1982
22. GUDEWICZ PW, MOLNAR J, LAI MZ, et al: Fibronectin-mediated uptake of gelatin-coated latex particles by peritoneal macrophages. J Cell Biol 87:427-433, 1980
23. POMMIER CG, INADA S, FRIES LF, et al: Plasma fibronectin enhances phagocytosis of opsonized particles by human peripheral blood monocytes. J Exp Med 157:1844-1854, 1983
24. JAFFE EA, MOSHER DF: Synthesis of fibronectin by cultured human endothelial cells. J Exp Med 147:1779-1791, 1978
25. CLARK RA, FOLKVORD JM, NIELSEN LD: Either exogenous or endogenous fibronectin can promote adherence of human endothelial cells. J Cell Sci 82:263-280, 1986
26. ABDELMOULA M, SPERTINI F, SHIBATA T, et al: IgG3 is the major source of cryoglobulins in mice. J Immunol 143:526-532, 1989
27. SALVARREY M, ROSTAGNO A: Affinity of fibronectin for polyclonal IgG. Clin Exp Immunol 76:92-96, 1989
28. MIYAMOTO S, AKIYAMA SK, YAMADA KM: Synergistic roles for receptor occupancy and aggregation in integrin transmembrane function. Science 267:883-885, 1995
29. PASTORE Y, LAJAUNIAS F, KUROKI A, et al: An experimental model of cryoglobulin-associated vasculitis in mice. Springer Semin Immunopathol 23:315-329, 2001
30. HOWARD TW, IANNINI MJ, BURGE JJ, et al: Rheumatoid factor, cryoglobulinemia, anti-DNA, and renal disease in patients with systemic lupus erythematosus. J Rheumatol 18:826-830, 1990
31. SIMIONESCU M, SIMIONESCU N: Endothelial transport of macromolecules: Transcytosis and endocytosis. A look from cell biology. Cell Biol Rev 25:5-78, 1991
32. BROWNE JT, HUTT MP, REGER JF, et al: Localization of " fibrinoid" deposit in lupus nephritis: An electron microscopic demonstration of glomerular endothelial cell phagocytosis. Arthritis Rheum 6:599-614, 1963
33. KATZ SM, SCHWARTZ AB, BREZIN J: Glomerular endothelial endocytosis of subendothelial electron dense deposits. Hum Pathol 11: 658-666, 1980