Aminophylline therapy during endotoxemia in anesthetized spontaneously breathing rats

Pharmacological Research

Volumn 49, Issue 1, 2004, Pages 45-50

  Fakioglu, Harun ^a   Gelvez, Javier ^a   Torbati, Dan ^a   Glover, Mark L ^a,b   Olarte, Jose L ^a   Camacho, Maria T ^a   Wolfsdorf, Jack ^a  

^a MIAMI CHILDREN'S HOSPITAL   (United States)

^b NOVA SOUTHEASTERN UNIVERSITY   (United States)

Author keywords

Aminophylline; Endotoxemia; Phosphodiesterase inhibitors; Sepsis

Indexed keywords

AMINOPHYLLINE; ENDOTOXIN; PHOSPHODIESTERASE INHIBITOR; SODIUM CHLORIDE; WATER;

ACID BASE BALANCE; ANESTHESIA; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTERY CATHETERIZATION; ARTICLE; BODY TEMPERATURE; BREATHING; CONTROLLED STUDY; DRUG EFFICACY; ENDOTOXEMIA; EUTHANASIA; EXPERIMENT; FEMORAL ARTERY; FEMORAL VEIN; FLUID BALANCE; GAS EXCHANGE; HEART; HEART RATE; HEMODYNAMICS; HYPERVENTILATION; HYPOTENSION; HYPOTHESIS; KIDNEY DISEASE; KIDNEY PARENCHYMA; LUNG EDEMA; LUNG PARENCHYMA; MEAN ARTERIAL PRESSURE; MODEL; NONHUMAN; PRIORITY JOURNAL; RAT; SEPSIS; SURGICAL TECHNIQUE; TACHYCARDIA; TRACHEOSTOMY; TREATMENT FAILURE;

EID: 0142246505     PISSN: 10436618     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.phrs.2003.03.001     Document Type: Article

References (30)

1. Shapiro L., Gelfand J.A. Cytokines and sepsis: pathophysiology and therapy. New Horizons. 1:1993;13-22.
2. Bone R.C., Grodzin C.J., Balk R.A. Sepsis: a new hypothesis for pathogenesis of the disease process. Chest. 112:1997;235-243.
3. Bone R.C., Balk R.A., Cerra F.B., Dellinger R.P., Fein A.M., Knaus W.A. et al. Definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis. The ACCP/SCCM Consensus Conference Committee. American College of Chest Physicians/Society of Critical Care Medicine. Chest. 101:1992;1644-1655.
4. Suffredini A.F. Current prospects for the treatment of clinical sepsis. Crit. Care Med. 22(Suppl.):1994;S12-S18.
5. Lefering R., Neugebauer E.A.M. Steroid controversy in sepsis and septic shock: a meta-analysis. Crit. Care Med. 23:1995;1294-1303.
6. Zeni F., Freeman-Natanson C. Anti-inflammatory therapies to treat sepsis and septic shock: a reassessment. Crit. Care Med. 25:1977;1095-1100.
7. Hsu K., Wang D., Chang M.L., Wu C.P., Chen H.I. Pulmonary edema induced by phorbol myristate acetate is attenuated by compounds that increase intracellular cAMP. Res. Exp. Med. 196:1996;17-28.
8. Sciuto A.M., Strickkand P.T., Kennedy T.P., Gurtner G.H. Postexposure treatment with aminophylline protects against phosgene-induced acute lung injury. Exp. Lung Res. 23:1977;317-332.
9. Nelson J.L., Alexander J.W., Mao J.X., Vohs T., Ogle C.K. Effect of pentoxifylline on survival and intestinal cytokine messenger RNA transcription in a rat model of ongoing peritoneal sepsis. Crit. Care Med. 27:1999;113-119.
10. Bacher A., Mayer N., Klimscha W., Oismuller C., Stelzer H., Hammerle A. Effects of pentoxifylline on hemodynamics and oxygenation in septic and nonseptic patients. Crit. Care Med. 25:1997;795-800.
11. Heller S., Weber K., Heller A., Urbaschek R., Koch T. Pentoxifylline improves bacterial clearance during hemorrhage and endotoxemia. Crit. Care Med. 27:1999;756-763.
12. Mizus I., Summer W., Farrukh I., Michael J.R., Gurtner G.H. Isoproterenol or aminophylline attenuate pulmonary edema after acid lung injury. Am. Rev. Respir. Dis. 131:1985;256-259.
13. Lindenschmidt R.C., Witschi H. Attenuation of pulmonary fibrosis in mice by aminophylline. Biochem. Pharmacol. 34:1985;4269-4273.
14. Nowak D., Roznieki J., Ruta U., Bednarowicz A., Izdebski J. The influence of aminophylline on human neutrophils: possible protection of lung from proteolytic injury. Arch. Immun. Allerg. Therap. Exp. 36:1988;351-360.
15. Churchill P.C. Renal effects of 2-chloroadenosine and their antagonism by aminophylline in anesthetized rats. J. Pharmacol. Exp. Therap. 222:1982;319-323.
16. Gouyon J.B., Arnaud M., Guignard J.P. Renal effects of low-dose aminophylline and enprofylline in newborn rabbits. Life Sci. 42:1988;1271-1278.
17. Mazkereth R., Laufer J., Jordan S., Pomerance J.J., Boichis H., Reichman B. Effects of theophylline on renal function in premature infants. Am. J. Perinatol. 14:1997;45-49.
18. Parker M.R., Willatts S.M. A pilot study to investigate the effects of an infusion of aminophylline on renal function following major abdominal surgery. Anaesthesia. 56:2001;670-675.
19. Rutherford J.D., Vatner S.F., Braunwald E. Effects and mechanism of action of aminophylline on cardiac function and regional blood flow distribution in conscious dogs. Circulation. 63:1981;378-387.
20. Matthay R.A., Mahler D.A. Theophylline improves global cardiac function and reduces dyspnea in chronic obstructive lung disease. J. Allergy Clin. Immun. 78:1986;793-799.
21. Crea F., Gaspardone A., Araujo L., De Silva R., Kaski J.C., Davies G.et al. Effects of aminophylline on cardiac function and regional myocardial perfusion: implications regarding its anti-ischemic action. Am. Heart J. 127:1994;817-824.
22. Spalding M.B., Ala-Kokko T.I., Kiviluoma K., Ruskoalo H., Alahuhtas S. The effect of aminophylline on right heart function in young pigs after ligation of the right coronary artery. Pharmacol. Toxicol. 86:2000;192-196.
23. Sato K., Stelzner T.J., O'Brien F.R., Weil J.V., Welsh C.H. Pentoxiphylline lessens the endotoxemia-induced increase in albumin clearance across pulmonary artery endothelial monolayers with and without neutrophils. Am. J. Respir. Cell Mol. Biol. 4:1991;219-227.
24. Stelzner T.J., Weil J.V., O'Brian R.F. Role of cyclic adenosine monophosphate in the induction of endothelial barrier properties. J. Cell Physiol. 139:1989;157-166.
25. Harada H., Ishizaka A., Yonemaru M., Mallick A.A., Hatherill J.R., Zheng H.et al. The effects of aminophylline on multiple organ damage after Escherichia coli sepsis. Am. Rev. Respir. Dis. 140:1989;974-980.
26. Camacho M.T., Totapally B.R., Torbati D., Wolfsdorf J. Pulmonary and extrapulmonary effects of increased colloid osmotic pressure during endotoxemia in rats. Chest. 29:2001;1972-1978.
27. Parker J.O., Kelkar K., West R.O. Hemodynamic effects of aminophylline in corpulmonale. Circulation. 33:1966;17-25.
28. Brackett D.J., Lai E.K., Lerner M.R., Wilson M.F., McCay P.B. Spin trapping of free radicals produced in vivo in heart and liver during endotoxemia. Free Radic. Res. Comms. 7:1989;315-324.
29. Yoshikawa T. Oxy radicals in endotoxin shock. Methods Enzymol. 186:1990;660-665.
30. Jansen N.G.J., Van Oeveren W., Hoiting B.H., Wildevuur C.R. Activation of plasma systems and blood cells by endotoxin in rabbits. Inflammation. 15:1991;81-90.