Overexpression of Prdx6 reduces H2O2 but does not prevent diet-induced atherosclerosis in the aortic root

Free Radical Biology and Medicine

Volumn 35, Issue 9, 2003, Pages 1110-1120

  Phelan, S A ^a   Wang, X ^b   Wallbrandt, P ^c   Forsman Semb, K ^d   Paigen, B ^b  

^a FAIRFIELD UNIVERSITY   (United States)

^b JACKSON LABORATORY   (United States)

^c UmanGenomics AB   (Sweden)

^d ASTRAZENECA R AND D   (Sweden)

Author keywords

Antioxidant; Aop2; Ath1; Atherosclerosis; Free radicals; Mice; Prdx6; Transgenic

Indexed keywords

ANTIOXIDANT; DNA; GLUTAMATE AMMONIA LIGASE; HIGH DENSITY LIPOPROTEIN; HYDROGEN PEROXIDE; LOW DENSITY LIPOPROTEIN; MESSENGER RNA; PEROXIDASE; PEROXIREDOXIN; PROTEIN; PROTEIN PRDX6; UNCLASSIFIED DRUG;

ALLELE; ANIMAL CELL; ANIMAL EXPERIMENT; ANTIOXIDANT ACTIVITY; AORTA ATHEROSCLEROSIS; AORTA ROOT; ARTICLE; ATH1 GENE; ATHEROGENIC DIET; CELL PROTECTION; CHOLESTEROL BLOOD LEVEL; CONTROLLED STUDY; DIET; DISEASE RESISTANCE; ENZYME ACTIVITY; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; GENE; GENE CONSTRUCT; GENE LIBRARY; GENE LOCUS; GENE OVEREXPRESSION; GENOTYPE; IMMUNOHISTOCHEMISTRY; LIPID PEROXIDATION; LIPOPROTEIN BLOOD LEVEL; LIVER; MOUSE; MOUSE STRAIN; NONHUMAN; OXIDATION; PERITONEUM MACROPHAGE; PHENOTYPE; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROTEIN EXPRESSION; SOUTHERN BLOTTING; TRANSGENIC MOUSE; WESTERN BLOTTING;

MAMMALIA; MUS MUSCULUS;

EID: 0142231080     PISSN: 08915849     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0891-5849(03)00462-3     Document Type: Article

References (41)

1. Libby P., Ridker P.M., Maseri A. Inflammation and atherosclerosis. Circulation. 105:2002;1135-1143.
2. Libby P. Inflammation in atherosclerosis. Nature. 420:2002;868-874.
3. Brown M.S., Goldstein J.L. Scavenging for receptors. Nature. 343:1990;508-509.
4. Witztum J.L. The oxidation hypothesis of atherosclerosis. Lancet. 344:1994;793-795.
5. Berliner J.A., Heinecke J.W. The role of oxidized lipoproteins in atherogenesis. Free Radic. Biol. Med. 20:1996;707-727.
6. Berliner J.A. Oxidized lipids in atherogenesis formation, destruction, and action . Thromb. Haemost. 78:1997;195-199.
7. Steinberg D. Low-density lipoprotein oxidation and its pathobiological significance. J. Biol. Chem. 272:(34):1997;20963-20966.
8. Kita T., Kume N., Minami M., Hayashida K., Murayama T., Sano H., Moriwaki H., Kataoka H., Nishi E., Horiuchi H., Arai H., Yokode M. Role of oxidized LDL in atherosclerosis. Ann. NY Acad. Sci. 947:2001;199-205.
9. Channon K.M. Oxidative stress and coronary plaque stability. Arterioscler. Thromb. Vasc. Biol. 22:(11):2002;1751-1752.
10. Paigen B., Mitchell D., Reue K., Morrow A., Lusis A.J., LeBoeuf R.C. Ath-1, a gene determining atherosclerosis susceptibility and high-density lipoprotein levels in mice. Proc. Natl. Acad. Sci. USA. 84:1987;3763-3767.
11. Phelan S.A., Beier D.R., Higgins D.C., Paigen B. Confirmation and high resolution mapping of an atherosclerosis susceptibility gene in mice on chromosome 1. Mamm. Genome. 13:(10):2002;548-553.
12. Iakoubova O.A., Pacella L.A., Her H., Beier D.R. LTW4 protein on mouse chromosome 1 is a member of a family of antioxidant proteins. Genomics. 42:1997;474-478.
13. Phelan S.A., Johnson K.A., Beier D.R., Paigen B. Characterization of the murine gene encoding Aop2 (antioxidant protein 2) and identification of two highly related genes. Genomics. 54:1998;132-139.
14. Phelan S. A. Aop2 (antioxidant protein 2) structure and function of a unique thiol-specific antioxidant . Antioxid. Redox Signal. 1:(4):1999;571-584.
15. Chae H., Robison K., Poole L., Church G., Storz G., Rhee S. Cloning and sequencing of thiol-specific anitoxidant from mammalian brain alkyl hydroperoxide reductase and thiol-specific antioxidant define a large family of antioxidant enzymes . Proc. Natl. Acad. Sci. USA. 91:1994;7017-7021.
16. Rhee S.G., Kang S.W., Netto L.E., Seo M.S., Stadtman E.R. A family of novel peroxidases, peroxiredoxins. Biofactors. 10:1999;207-209.
17. Fujii J., Ikeda Y. Advances in our understanding of peroxiredoxin, a multifunctional, mammalian redox protein. Redox Rep. 7:2002;123-130.
18. Liao F., Andalibi A., deBeer F.C., Fogelman A.M., Lusis J. Genetic control of inflammatory gene induction and NF-κB-like transcription factor activation in response to an atherogenic diet in mice. J. Clin. Invest. 91:1993;2572-2579.
19. Liao F., Andalibi A., Qiao J.-H., Allayee H., Fogelman A.M., Lusis A.J. Genetic evidence for a common pathway mediating oxidative stress, inflammatory gene induction, and aortic fatty streak formation in mice. J. Clin. Invest. 94:1994;877-884.
20. Nishina P.N., Verstuyft J., Paigen B. Synthetic low- and high-fat diets for the study of atherosclerosis in the mouse. J. Lipid Res. 31:1990;859-869.
21. Wang X., Phelan S.A., Forsman-Semb K., Taylor E.F., Petros C., Brown A., Lerner C.P., Paigen B. Mice with targeted mutation of peroxiredoxin 6 develop normally but are susceptible to oxidative stress. J. Biol. Chem. 278:(27):2003;25179-25190.
22. Kang S.W., Chae H.Z., Seo M.S., Kim K.H., Baines I.C., Rhee S.G. Mammalian peroxiredoxin isoforms can reduce hydrogen peroxide generated in response to growth factors and tumor necrosis factor-α J. Biol. Chem. 273:(11):1998;6297-6302.
23. 2 mixed-function oxidation sytem. J. Biol. Chem. 263:1988;4704-4711.
24. Ohba M., Shibanuma M., Kuroki T., Nose K. Production of hydrogen peroxide by transforming growth factor-β1 and its involvement in induction of egr-1 in mouse osteoblastic cells. J. Cell. Biol. 126:1994;1079-1088.
25. Nishina P.M., Lowe S., Verstuyft J., Naggert J.K., Kuypers F.A., Paigen B. Effects of dietary fats from plant and animal sources on diet-induced fatty streak lesions in C57BL/6J mice. J. Lipid Res. 34:1993;1413-1422.
26. Izzo C., Grillo F., Murado E. Improved method for determination of high-density lipoproteins by using polyethylene glycol 6000. Clin. Chem. 27:1981;371-374.
27. Wang X., Greilberger J., Ledinski G., Kager G., Jurgens G. Binding and uptake of differently oxidized low-density lipoprotein in mouse peritoneal macrophages and THP-1 macrophages involvement of negative charges as well as oxidation-specific epitopes . J. Cell Biochem. 81:2001;557-569.
28. Wang X., Greilberger J., Jurgens G. Time-resolved fluorometric assay for measuring cell binding and association of native and oxidized low-density lipoproteins to macrophages. Anal. Biochem. 267:1999;271-278.
29. Hammer A., Kager G., Dohr G., Rabl H., Ghassempur I., Jurgens G. Generation, characterization, and histochemical application of monoclonal antibodies selectively recognizing oxidatively modified apoB-containing serum lipoproteins. Arterioscler. Thromb. Vasc. Biol. 15:1995;704-713.
30. Paigen B., Morrow A., Holmes P.A., Mitchell D., Williams R.A. Quantitative assessment of atherosclerotic lesions in mice. Atherosclerosis. 68:1987;231-240.
31. Choi H.-J., Kang S.W., Yang C.-H., Rhee S.G., Ryu S.-E. Crystal structure of a novel human peroxidase enzyme at 2.0 A resolution. Nat. Struct. Biol. 5:1998;400-406.
32. Halliwell B., Gutteridge J.M.C. Free radical in biology and medicine. 3rd ed:1999;Oxford University Press, New York.
33. Fisher A.B., Dodia C., Manevich Y., Chen J.W., Feinstein S.I. Phospholipid hydroperoxides are substrates for nonselenium glutathione peroxidase. J. Biol. Chem. 274:1999;21326-21334.
34. Manevich Y., Sweitzer T., Pak J.H., Feinstein S.I., Muzykantov V., Fisher A.B. 1-Cys peroxiredoxin overexpression protects cells against phospholipid peroxidation-mediated membrane damage. Proc. Natl. Acad. Sci. USA. 99:2002;11599-11604.
35. Pak J.H., Manevich Y., Kim H.S., Feinstein S.I., Fisher A.B. An antisense oligonucleotide to 1-cys peroxiredoxin causes lipid peroxidation and apoptosis in lung epithelial cells. J. Biol. Chem. 277:2002;49927-49934.
36. Munz B., Frank S., Hübner G., Olsen E., Werner S. A novel type of glutathione peroxidase expression and regulation during wound repair . Biochem. J. 326:1997;579-585.
37. Frank S., Munz B., Werner S. The human homologue of a bovine nonselenium glutathione peroxidase is a novel keratinocyte growth factor-regulated gene. Oncogene. 14:1997;915-921.
38. Sparling N., Phelan S.A. Identification of multiple transcripts for antioxidant protein 2 (Aop2) differential regulation by oxidative stress and growth factors . Redox Rep. 8:(2):2003;87-94.
39. Lander H.M. An essential role for free radicals and derived species in signal transduction. FASEB J. 11:1997;118-124.
40. Rhee S.G. Redox signaling hydrogen peroxide as intracellular messenger . Exp. Mol. Med. 31:1999;53-59.
41. Hoffmann B., Hecht H.J., Flohe L. Peroxiredoxins. Biol. Chem. 383:2002;347-364.