mRNA levels of the insulin-signaling molecule SORBS1 in the adipose depots of nondiabetic women

Obesity Research

Volumn 11, Issue 4, 2003, Pages 586-590

  Yang, Wei Shiung ^a   Lee, Wei Jei ^b   Huang, Kuo Chin ^a   Lee, Kuan Ching ^a   Chao, Chia Ling ^a   Chen, Chi Ling ^a   Tai, Tong Yuan ^a   Chuang, Lee Ming ^a,c  

^a NATIONAL TAIWAN UNIVERSITY   (Taiwan)

^b EN CHU KONG HOSPITAL   (Taiwan)

^c NATIONAL TAIWAN UNIVERSITY HOSPITAL   (Taiwan)

Author keywords

Adipose; Depot; mRNA; SORBS1

Indexed keywords

ACTIN BINDING PROTEIN; INSULIN; MESSENGER RNA; SORBS1 PROTEIN, HUMAN;

ABDOMEN; ADIPOSE TISSUE; ADULT; ARTICLE; BLOOD; BODY MASS; CHEMISTRY; FEMALE; GENETICS; HUMAN; MIDDLE AGED; OMENTUM; POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; STATISTICAL MODEL;

ABDOMEN; ADIPOSE TISSUE; ADULT; BODY MASS INDEX; FEMALE; HUMANS; INSULIN; LINEAR MODELS; MICROFILAMENT PROTEINS; MIDDLE AGED; OMENTUM; POLYMERASE CHAIN REACTION; RNA, MESSENGER; SIGNAL TRANSDUCTION;

EID: 0142217974     PISSN: 10717323     EISSN: None     Source Type: Journal    
DOI: 10.1038/oby.2003.82     Document Type: Article

References (13)

1. Fruhbeck G, Gomez-Ambrosi J, Muruzabal FJ, Burrell MA. The adipocyte: a model for integration of endocrine and metabolic signaling in energy metabolism regulation. Am J Physiol Endocrinol Metab. 2001;280:E827-47.
2. Wajchcnbcrg BL. Subcutaneous and visceral adipose tissue: their relation to the metabolic syndrome. Endocr Rev. 2000;21:697-738.
3. Lin W-H, Huang C-J, Liu M-W, et al. Cloning, mapping, and characterization of the human sorbin and SH3 domain containing 1 (SORBS1) gene: a protein associated with c-Abl during insulin signaling in the hepatoma cell line Hep3B. Genomics. 2001;74:12-20.
4. Mandai K, Nakanishi H, Satoh A, et al. Ponsin/SH3P12: an 1-afadin- and vinculin-binding protein localized at cell-cell and cell-matrix adherens junctions. J Cell Biol. 1999;144:1001-17.
5. Ribon V, Printen JA, Hoffman NG, Kay BK, Saltiel AR. A novel, multifunctional c-Cbl binding protein in insulin receptor signaling in 3T3-L1 adipocytes. Mol Cell Biol. 1998;18:872-9.
6. Saltiel AR, Kahn CR. Insulin signalling and the regulation of glucose and lipid metabolism. Nature. 2001;414:799-806.
7. Liu J, Kimura A, Baumann CA, Saltiel AR. APS facilitates c-Cbl tyrosine phosphorylation and GLUT4 translocation in response to insulin in 3T3-L1 adipocytes. Mol Cell Biol. 2002;22:3599-609.
8. Ribon V, Johnson JH, Camp HS, Saltiel AR. Thiazo-lidinediones and insulin resistance: peroxisome proliferator activated receptor gamma activation stimulates expression of the CAP gene. Proc Natl Acad Sci USA. 1998;95:14751-6.
9. Baumann CA, Brady MJ, Saltiel AR. Activation of glycogen synthase by insulin in 3T3-L1 adipocytes involves c-Cbl-associating protein (CAP)-dependent and CAP-independent signaling pathways. J Biol Cliem. 2001;276:6065-8.
10. Chiang SH, Baumann CA, Kanzaki M, et al. Insulin-stimulated GLUT4 translocation requires the CAP-dependent activation of TC10. Nature. 2001;410:944-8.
11. Chiang SH, Hou JC, Hwang J, Pessin JE, Saltiel AR. Cloning and functional characterization of related TC10 isoforms, a subfamily of Rho proteins involved in insulin-stimulated glucose transport. J Biol Chem. 2002;277:13067-73.
12. Lin WH, Chiu KC, Chang HM, Lee KC, Tai TY, Chuang LM. Molecular scanning of the human sorbin and SH3-domain-containing-1 (SORBS1) gene: positive association of the T228A polymorphism with obesity and type 2 diabetes. Hum Mol Genet. 2001;10:1753-60.
13. Yang WS, Lee WJ, Funahashi T, et al. Weight reduction increases plasma levels of an adipose-derived anti-inflammatory protein, adiponectin. J Clin Endocrinol Metab. 2001;86:3815-9.