Role of c-Myc in nitric oxide-mediated suppression of cytochrome P450 3A4

Life Sciences

Volumn 74, Issue 1, 2003, Pages 99-108

  Watabe, Masahiko ^a   Isogai, Yumiko ^a   Numazawa, Satoshi ^a   Yoshida, Takemi ^a  

^a SHOWA UNIVERSITY   (Japan)

Author keywords

Myc; Nitric oxide; NO; P450

Indexed keywords

CALCITRIOL; CYTOCHROME P450 3A4; MESSENGER RNA; MYC PROTEIN; NITRIC OXIDE;

ARTICLE; CELL STRAIN CACO 2; CONCENTRATION RESPONSE; CONTROLLED STUDY; GENE EXPRESSION REGULATION; HUMAN; HUMAN CELL; ONCOGENE C MYC; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN INDUCTION; UPREGULATION;

EID: 0142217523     PISSN: 00243205     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.lfs.2003.07.006     Document Type: Article

References (26)

1. Abdel-Razzak Z., Loyer P., Fautrel A., Gautier J.C., Corcos L., Turlin B., Beaune P., Guillouzo A. Cytokines down-regulate expression of major cytochrome P-450 enzymes in adult human hepatocytes in primary culture. Molecular Pharmacology. 44:1993;707-715.
2. Antonson P., Pray M.G., Jacobsson A., Xanthopoulos K.G. Myc inhibits CCAAT/enhancer-binding protein alpha-gene expression in HIB-1B hibernoma cells through interactions with the core promoter region. European Journal of Biochemistry. 232:1995;397-403.
3. Carlson T.J., Billings R.E. Role of nitric oxide in the cytokine-mediated regulation of cytochrome P-450. Molecular Pharmacology. 49:1996;796-801.
4. Geller D.A., Nussler A.K., Di Silvio M., Lowenstein C.J., Shapiro R.A., Wang S.C., Simmons R.L., Billiar T.R. Cytokines, endotoxin, and glucocorticoids regulate the expression of inducible nitric oxide synthase in hepatocytes. Proceedings of the National Academy of Sciences of the United States of America. 90:1993;522-526.
5. Hall S.D., Thummel K.E., Watkins P.B., Lown K.S., Benet L.Z., Paine M.F., Mayo R.R., Turgeon D.K., Bailey D.G., Fontana R.J., Wrighton S.A. Molecular and physical mechanisms of first-pass extraction. Drug Metabolism and Disposition. 27:1999;161-166.
6. Hara H., Mitani N., Adachi T. Inhibitory effect of nitric oxide on the induction of cytochrome P450 3A4 mRNA by 1,25-dihydroxyvitamin D3 in Caco-2 cells. Free Radical Research. 33:2000;279-285.
7. Holt J.T., Redner R.L., Nienhuis A.W. An oligomer complementary to c-myc mRNA inhibits proliferation of HL-60 promyelocytic cells and induces differentiation. Molecular and Cellular Biology. 8:1988;963-973.
8. Kolars J.C., Schmiedlin-Ren P., Schuetz J.D., Fang C., Watkins P.B. Identification of rifampin-inducible P450IIIA4 (CYP3A4) in human small bowel enterocytes. Journal of Clinical Investigation. 90:1992;1871-1878.
9. Li L.H., Nerlov C., Prendergast G., MacGregor D., Ziff E.B. c-Myc represses transcription in vivo by a novel mechanism dependent on the initiator element and Myc box II. The EMBO Journal. 13:1994;4070-4079.
10. Minamiyama Y., Takemura S., Imaoka S., Funae Y., Tanimoto Y., Inoue M. Irreversible inhibition of cytochrome P450 by nitric oxide. The Journal of Pharmacology and Experimental Therapeutics. 283:1997;1479-1485.
11. Mink S., Mutschler B., Weiskirchen R., Bister K., Klempnauer K.H. A novel function for Myc: inhibition of C/EBP-dependent gene activation. Proceedings of the National Academy of Sciences of the United States of America. 93:1996;6635-6640.
12. Moncada S., Palmer R.M., Higgs E.A. Nitric oxide: physiology, pathophysiology, and pharmacology. Pharmacological Reviews. 43:1991;109-142.
13. Nathan C. Nitric oxide as a secretory product of mammalian cells. The FASEB Journal. 6:1992;3051-3064.
14. Nelson D.R., Kamataki T., Waxman D.J., Guengerich F.P., Estabrook R.W., Feyereisen R., Gonzalez F.J., Coon M.J., Gunsalus I.C., Gotoh O., Okada K., Nebert W. The P450 superfamily: update on new sequences, gene mapping, accession numbers, early trivial names of enzymes, and nomenclature. DNA and Cell Biology. 12:1993;1-51.
15. Nussler A.K., Di Silvio M., Billiar T.R., Hoffman R.A., Geller D.A., Selby R., Madariaga J., Simmons R.L. Stimulation of the nitric oxide synthase pathway in human hepatocytes by cytokines and endotoxin. Journal of Experimental Medicine. 176:1992;261-264.
16. Ourlin J.C., Jounaidi Y., Maurel P., Vilarem M.J. Role of the liver-enriched transcription factors C/EBP alpha and DBP in the expression of human CYP3A4 and CYP3A7. Journal of Hepatology. 26:1997;54-62.
17. Roy A.L., Carruthers C., Gutjahr T., Roeder R.G. Direct role for Myc in transcription initiation mediated by interactions with TFII-I. Nature. 365:1993;359-361.
18. Shi Y., Glynn J.M., Guilbert L.J., Cotter T.G., Bissonnette R.P., Green D.R. Role for c-myc in activation-induced apoptotic cell death in T cell hybridomas. Science. 257:1992;212-214.
19. Shimada T., Guengerich F.P. Evidence for cytochrome P-450NF, the nifedipine oxidase, being the principal enzyme involved in the bioactivation of aflatoxins in human liver. Proceedings of the National Academy of Sciences of the United States of America. 86:1989;462-465.
20. Thummel K.E., Brimer C., Yasuda K., Thottassery J., Senn T., Lin Y., Ishizuka H., Kharasch E., Schuetz J., Schuetz E. Transcriptional control of intestinal cytochrome P-4503A by 1alpha,25-dihydroxy vitamin D3. Molecular Pharmacology. 60:2001;1399-1406.
21. Tinel M., Elkahwaji J., Robin M.A., Fardel N., Descatoire V., Haouzi D., Berson A., Pessayre D. Interleukin-2 overexpresses c-myc and down-regulates cytochrome P-450 in rat hepatocytes. The Journal of Pharmacology and Experimental Therapeutics. 289:1999;649-655.
22. Watabe M., Ito K., Masuda Y., Nakajo S., Nakaya K. Activation of AP-1 is required for bufalin-induced apoptosis in human leukemia U937 cells. Oncogene. 16(6):1998;779-787.
23. Watabe M., Kawazoe N., Masuda Y., Nakajo S., Nakaya K. Bcl-2 protein inhibits bufalin-induced apoptosis through inhibition of mitogen-activated protein kinase activation in human leukemia U937 cells. Cancer Research. 57(15):1997;3097-3100.
24. Watabe M., Masuda Y., Nakajo S., Yoshida T., Kuroiwa Y., Nakaya K. The cooperative interaction of two different signaling pathways in response to bufalin induces apoptosis in human leukemia U937 cells. Journal of Biological Chemistry. 271(24):1996;14067-14072.
25. Watabe M., Nakajo S., Yoshida T., Kuroiwa Y., Nakaya K. Treatment of U937 cells with bufalin induces the translocation of casein kinase 2 and modulates the activity of topoisomerase II prior to the induction of apoptosis. Cell Growth and Differentiation. 8(8):1997;871-879.
26. Watkins P.B., Wrighton S.A., Schuetz E.G., Molowa D.T., Guzelian P.S. Identification of glucocorticoid-inducible cytochromes P-450 in the intestinal mucosa of rats and man. Journal of Clinical Investigation. 80:1987;1029-1036.