Bcl-2 protein inhibits bufalin-induced apoptosis through inhibition of mitogen-activated protein kinase activation in human leukemia U937 cells

Cancer Research

Volumn 57, Issue 15, 1997, Pages 3097-3100

  Watabe, Masahiko ^a   Kawazoe, Nobuko ^a   Masuda, Yutaka ^a   Nakajo, Shigeo ^a   Nakaya, Kazuyasu ^a  

^a SHOWA UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

BUFALIN; MITOGEN ACTIVATED PROTEIN KINASE; PROTEIN BCL 2; TRANSCRIPTION FACTOR AP 1;

APOPTOSIS; ARTICLE; CONTROLLED STUDY; ENZYME INHIBITION; HUMAN; HUMAN CELL; LEUKEMIA CELL LINE; PRIORITY JOURNAL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION;

ANTINEOPLASTIC AGENTS; APOPTOSIS; BUFANOLIDES; CA(2+)-CALMODULIN DEPENDENT PROTEIN KINASE; GENE EXPRESSION; HUMANS; LEUKEMIA; MITOGEN-ACTIVATED PROTEIN KINASE KINASES; MONOCYTES; PROTEIN KINASES; PROTO-ONCOGENE PROTEINS C-BCL-2; RNA, MESSENGER; TRANSCRIPTION FACTOR AP-1; TRANSFECTION; TUMOR CELLS, CULTURED;

EID: 0030855164     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (15)

1. Tsujimoio, Y., Jaffe, E., Cossman, J., Gorham, J., Nowell, P. C, and Croce, C. M. Clustering of breakpoints on chromosome II in human B-cell neoplasms with the t(11;14) chromosome translocation. Nature (Lond.), 315: 340-343, 1985.
2. Tsujimoto, Y., and Croce, C. M. Analysis of the structure, transcripts, and protein products of bcl-2, the gene involved in human follicular lymphoma. Proc. Nail. Acad. Sei. USA., 83: 5214-5218, 1986.
3. Hockenbery, D. M., Oltvai, Z. N., Yin, X-M., Milliman, C. L., and Korsmeycr, S. J. Bcl-2 functions in an antioxidant pathway to prevent apoptosis. Cell, 75: 241-251, 1993.
4. Steinman, H. M. The Bcl-2 oncoprotein functions as a pro-oxidanl. J. Biol. Chem., 270; 3487-3490, 1995.
5. Oltvai, Z. N., Milliman, C. A., and Korsmeycr, S. J. Bcl-2 hcterodimerizes in vivo with a conserved homolog, Bax, that accelerates programed cell death. Cell, 74: 609-619, 1993.
6. Wang, H-G., Miyashita, T., Takayama, S., Sato, T., Torigoe, T., Krajewski, S., Tanaka, S., Hovey, L., III, Troppmair, J., Rapp, U., and Reed, J. C. Apoptosis regulation by interaction of Bcl-2 protein and Raf-1 kinase. Oncogene, 9: 2751-2756, 1994.
7. Fernandez-Sarabia, M. J., and Bischoff, J. R. Bcl-2 associates with the ras-related protein R-ras p23. Nature (Lond.), 366: 274-275, 1993.
8. Lowe, D. G., Capon, D. J., Delwart, E., Sakaguchi, A. Y., Naylor, S. L., and Goeddel, D. V. Structure of the human and murine R-ras gene, novel genes closely related to ras proto-oncogenes. Cell, 48: 137-146, 1987.
9. Jing, Y., Ohizumi, H., Kawazoe, N., Hashimoto, S., Masuda, Y., Nakajo, S., Yoshida. T., Kuroiwa, Y., and Nakaya, K. Selective inhibitory effect of bufalin on growth of human tumor cells in vitro. Jpn. J. Cancer Res., 85: 645-651, 1994.
10. Watabe, M., Masuda, Y., Nakajo, S., Yoshida, T., Kuroiwa, Y., and Nakaya, K. The cooperative interaction of two different signaling pathways in response to bufalin induces apoplosis in human leukemia U937 cells. J. Biol. Chem., 271: 14067-14073, 1996.
11. Noguchi, K., Nakajima, M., Naito, M., and Tsuruo, T. Inhibition by differentiation-inducing agents of wild-type p53-dependent apoptosis in HL-60 cells. Jpn. J. Cancer Res., 56:217-223, 1995.
12. Chomczynski, P., and Sacchi, N. Single-step method of RNA isolation by acid guanidinium thioeyanate-phenol-chloroform extraction. Anal. Biochem., 162: 156-159, 1987.
13. Maniatis, T., Fritsch, E. F., and Sambrook, J. (eds.). Molecular Cloning: A Laboratory Manual, pp. 188-206. Cold Spring Harbor, NY: Cold Spring Harbor Laboratory, 1982.
14. Masuda, Y., Kawazoe, N., Shigeo, N., Yoshida. T., Kuroiwa, Y., and Nakaya, K. Bufalin induces apoptosis and influences the expression of apoptosis-relatcd genes in human leukemia cells. Leuk. Res., 19: 549-556, 1995.
15. Kouzarides, T., and Ziff. E. The role of the leucine zipper in the fos-jun interaction. Nature (Lond.), 336: 646-651, 1988.