Tolerance and Autoimmunity in Anti-GBM Disease

Journal of the American Society of Nephrology

Volumn 14, Issue 11, 2003, Pages 2988-2989

  Salama, Alan D ^a   Levy, Jeremy B ^a  

^a CHARING CROSS HOSPITAL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ACUTE KIDNEY FAILURE; ANTIGEN RECOGNITION; AUTOIMMUNITY; EDITORIAL; GOODPASTURE SYNDROME; HUMAN; IMMUNE RESPONSE; IMMUNOLOGICAL TOLERANCE; PRIORITY JOURNAL;

EID: 0142213867     PISSN: 10466673     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.ASN.0000096785.86791.68     Document Type: Editorial

References (14)

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3. Stanton MC, Tange JD: Goodpasture's syndrome (pulmonary haemorrhage associated with glomerulonephritis). Aust NZ J Med 7: 132-144, 1958
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8. Ryan JJ, Mason PJ, Pusey CD, Turner N: Recombinant alpha-chains of type IV collagen demonstrate that the amino terminal of the Goodpasture autoantigen is crucial for antibody recognition. Clin Exp Immunol 113: 17-27, 1998
9. Hellmark T, Burkhardt H, Wieslander J: Goodpasture disease. Characterization of a single conformational epitope as the target of pathogenic autoantibodies. J Biol Chem 274: 25862-25868, 1999
10. Netzer KO, Leinonen A, Boutaud A, Borza DB, Todd P, Gunwar S, Langeveld JP, Hudson BG: The goodpasture autoantigen. Mapping the major conformational epitope(s) of alpha3(IV) collagen to residues 17-31 and 127-141 of the NC1 domain. J Biol Chem 274: 11267-11274, 1999
11. Wong D, Phelps RG, Turner AN: The Goodpasture antigen is expressed in the human thymus. Kidney Int 60: 1777-1783, 2001
12. Salama AD, Chaudhry AN, Ryan JJ, Eren E, Levy JB, Pusey CD, Lightstone L, Lechler RI: In Goodpasture's Disease, CD4(+) T Cells Escape Thymic Deletion and Are Reactive with the Autoantigen alpha3(IV)NC1. J Am Soc Nephrol 12: 1908-1915, 2001
13. Salama AD, Chaudhry AN, Holthaus KA, Mosley K, Kalluri R, Sayegh MH, Lechler RI, Pusey CD, Lightstone L: Regulation by CD25+ lymphocytes of autoantigen-specific T cell responses in Goodpasture's (anti-GBM) disease. Kidney Int 2003, in press
14. Cairns LS, Phelps RG, Bowie L, Hall AM, Saweirs WWM, Rees AJ, Barker RN: The fine specificity and cytokine profile of T-Helper cells responsive to the α3 chain of type IV collagen in Goodpasture's disease. J Am Soc Nephrol 14: 2801-2812, 2003