Gene transfer into the liver by plasmid injection into the portal vein combined with electroporation

Journal of Gene Medicine

Volumn 5, Issue 3, 2003, Pages 201-208

  Kobayashi, Shogo ^a   Dono, Keizo ^a   Tanaka, Toshiyuki ^a   Takahara, Shiro ^a   Isaka, Yoshitaka ^a   Imai, Enyu ^a   Nagano, Hiroaki ^a   Tomoaki, Kato ^a   Umeshita, Koji ^a   Nakamori, Shoji ^a   Sakon, Masato ^a   Monden, Morito ^a  

^a OSAKA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

Electroporation; In vivo; Local gene therapy; Rat liver

Indexed keywords

FLUORESCEIN ISOTHIOCYANATE; GREEN FLUORESCENT PROTEIN; LUCIFERASE; OLIGODEOXYNUCLEOTIDE; PLASMID DNA; FLUORESCENT DYE;

ANESTHESIA INDUCTION; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELLULAR DISTRIBUTION; CENTRAL VEIN; CHRONIC LIVER DISEASE; CLAMP; COLON; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG DETERMINATION; DRUG DISTRIBUTION; DRUG SOLUTION; ELECTRIC POTENTIAL; ELECTRICITY; ELECTROPORATION; ENZYME ACTIVITY; ENZYME LOCALIZATION; FLUORESCENCE ANALYSIS; GENE EXPRESSION; GENE INDUCTION; GENE LOCATION; GENE TRANSFER; GENETIC TRANSFECTION; INJECTION SITE; LIVER; LIVER CELL; LIVER DISEASE; LIVER FUNCTION; LIVER SURGERY; MAJOR SURGERY; MALE; NONHUMAN; PORTAL VEIN; PRIORITY JOURNAL; RAT; RAT STRAIN; VEIN CATHETERIZATION; ANIMAL; INTRAVENOUS DRUG ADMINISTRATION; METABOLISM; PLASMID; REPORTER GENE; WISTAR RAT;

ANIMALS; ELECTROPORATION; FLUORESCEIN-5-ISOTHIOCYANATE; FLUORESCENT DYES; GENE TRANSFER TECHNIQUES; GENES, REPORTER; INJECTIONS, INTRAVENOUS; LIVER; MALE; PLASMIDS; PORTAL VEIN; RATS; RATS, WISTAR;

EID: 0142197229     PISSN: 1099498X     EISSN: None     Source Type: Journal    
DOI: 10.1002/jgm.329     Document Type: Article

References (19)

1. Minami H, Tada K, Chowdhury NR, et al. Enhancement of retrovirus-mediated gene transfer to rat liver in vivo by infusion of hepatocyte growth factor and triiodothyronine. J Hepatol 2000; 33: 183-188.
2. Bosch A, McCray PB, Walters KS, et al. Effects of keratinocyte and hepatocyte growth factor in vivo: implications for retrovirus-mediated gene transfer to liver. Hum Gene Ther 1998; 9: 1747-1754.
3. Muruve DA, Barnes MJ, Stillman IE, et al. Adenoviral gene therapy leads to rapid induction of multiple chemokines and acute neutrophil-dependent hepatic injury in vivo. Hum Gene Ther 1999; 10: 965-976.
4. Titomirov AV, Sukharev S, Kistanova E. In vivo electroporation and stable transformation of skin cells of newborn mice by plasmid DNA. Biochim Biophys Acta 1991; 1088: 131-134.
5. Heller R, Jaroszeski M, Atkin A, et al. In vivo gene electroinjection and expression in rat liver. FEBS Lett 1996; 389: 225-228.
6. Zhang G, Vargo D, Budker V, et al. Expression of naked plasmid DNA injected into the afferent and efferent vessels of rodent and dog livers. Hum Gene Ther 1997; 8: 1763-1772.
7. Liu F, Song Y, Liu D. Hydrodynamics-based transfection in animals by systemic administration of plasmid DNA. Gene Ther 1999; 6: 1258-1266.
8. Aihara H, Miyazaki J. Gene transfer into muscle by electroporation in vivo. Nat Biotechnol 1998; 16: 867-870.
9. Tanaka T, Ichimaru N, Takahara S, et al. In vivo gene transfer of hepatocyte growth factor to skeletal muscle prevents changes in rat kidneys after 5/6 nephrectomy. Am J Transpl (in press).
10. Xue F, Takahara T, Yata Y, et al. Attenuated acute liver injury in mice by naked hepatocyte growth factor gene transfer into skeletal muscle with electroporation. Gut 2002; 50: 558-562.
11. Tsujie M, Isaka Y, Nakamura H, et al. Electroporation-mediated gene transfer that targets glomemli. J Am Soc Nephrol 2001; 12: 949-954.
12. Yamashita YI, Shimada M, Hasegawa H, et al. Electroporation-mediated interleukin-12 gene therapy for hepatocellular carcinoma in the mice model. Cancer Res 2001; 61: 1005-1012.
13. Suzuki T, Shin BC, Fujikura K, et al. Direct gene transfer into rat liver cells by in vivo electroporation. FEBS Lett 1998; 425: 436-440.
14. Tokunaga Y, Ozaki N, Wakashiro S, et al. Effects of perfusion pressure during flushing on the viability of the procured liver using noninvasive fluorometry. Transplantation 1988; 45: 1031-1035.
15. Manthorpe M, et al. Gene therapy by intramuscular injection of plasmid DNA: studies on firefly luciferase gene expression in mice. Hum Gene Ther 1993; 4: 419.
16. Schleicher E, Wieland OH. Evaluation of the Bradford method for protein determination in body fluids. J Clin Chem Clin Biochem 1978; 16: 533-534.
17. Wolf HK, Zarnegar R, Michalopoulos GK. Localization of hepatocyte growth factor in human and rat tissues: an immunohistochemical study. Hepatology 1991; 14: 488-494.
18. Liu F, Huang L. Improving plasmid DNA-mediated liver gene transfer by prolonging its retention in the hepatic vasculature. J Gene Med 2001; 3: 569-576.
19. Baba M, Iishi H, Tatsuta M. In vivo electroporetic transfer of bcl-2 antisense oligonucleotide inhibits the development of hepatocellular carcinoma in rats. Int J Cancer 2000; 85: 260-266.