Synthesis of a conformationally restricted analog of pregabalin by stereoselective alkylation of a chiral pyrrolidin-2-one

Tetrahedron Asymmetry

Volumn 14, Issue 21, 2003, Pages 3353-3358

  Galeazzi, Roberta ^a   Martelli, Gianluca ^a   Mobbili, Giovanna ^a   Orena, Mario ^a   Rinaldi, Samuele ^a  

^a UNIVERSITÀ POLITECNICA DELLE MARCHE   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

3 BENZYLOXYMETHYL 1 (TERT BUTOXYCARBONYL) 4 (2' METHYLPROP 1' YL)PYRROLIDINE; 4 BENZYLOXYMETHYL 3 (2'' METHYLPROP 1'' YL) 1 (1' PHENYLETHYL)PYRROLIDIN 2 ONE; 4 BENZYLOXYMETHYL 3 (2'' METHYLPROP 1'' YL) 1 (1' PHENYLETHYL)PYRROLIDINE; 4 BENZYLOXYMETHYLPYRROLIDIN 2 ONE; BENZYL DERIVATIVE; CARBONYL DERIVATIVE; CARBOXYLIC ACID DERIVATIVE; KETONE DERIVATIVE; NITROGEN; PREGABALIN; PYRROLIDINE CARBOXYLIC ACID; PYRROLIDINE DERIVATIVE; UNCLASSIFIED DRUG;

ALKYLATION; ARTICLE; CHIRALITY; CONFORMATION; DRUG STRUCTURE; DRUG SYNTHESIS; NUCLEAR OVERHAUSER EFFECT; OXIDATION; PRIORITY JOURNAL; PROTON NUCLEAR MAGNETIC RESONANCE; REDUCTION; STEREOCHEMISTRY;

EID: 0142196046     PISSN: 09574166     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0957-4166(03)00599-8     Document Type: Article

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