Synergistic effects of DL111-IT in combination with mifepristone and misoprostol on termination of early pregnancy in preclinical studies

Contraception

Volumn 68, Issue 4, 2003, Pages 289-295

  He, Qiao jun ^a   Yang, Bo ^a   Wang, Wei fang ^b   Wu, Hong Hai ^a   Fang, Rui ying ^a  

^a ZHEJIANG UNIVERSITY   (China)

^b Zhejiang Xian ju Pharmaceutical Co   (China)

Author keywords

DL111 IT; Early pregnancy termination; Mifepristone; Misoprostol; Synergistic effect

Indexed keywords

3 (2 ETHYLPHENYL) 5 (3 METHOXYPHENYL) 1H 1,2,4 TRIAZOLE; CONTRACEPTIVE AGENT; MIFEPRISTONE; MISOPROSTOL; UNCLASSIFIED DRUG;

ACUTE TOXICITY; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; DRUG DOSE REDUCTION; DRUG EFFECT; DRUG EFFICACY; DRUG MEGADOSE; DRUG POTENTIATION; DRUG SAFETY; DRUG SCREENING; FEMALE; FIRST TRIMESTER PREGNANCY; FUNCTION TEST; IN VITRO STUDY; IN VIVO STUDY; LABOR INDUCTION; LD 50; LOW DRUG DOSE; MALE; MOUSE; NONHUMAN; PIGEON; PREGNANCY TERMINATION; RAT; STATISTICAL SIGNIFICANCE; TOXICITY TESTING; UTERUS CONTRACTION; VOMITING;

EID: 0142188593     PISSN: 00107824     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0010-7824(03)00179-3     Document Type: Article

References (17)

1. Kovacs L., Sas M., Resch B.A., et al. Termination of very early pregnancy by RU486-an antiprogestational compound. Contraception. 29:1984;399-410.
2. Shoupe D., Mishell D.R., Brenner P.F., Spitz I.M. Pregnancy termination with a high and medium dosage regimen of RU486. Contraception. 33:1986;455-461.
3. Wu S.C., Gao J., Wu Y.M., et al. Clinical trial on termination of early pregnancy with RU486 in combination with prostaglandin. Contraception. 46:1992;203-210.
4. Creinin M.D., Potter C., Holovanisin M., et al. Mifepristone and misoprostol and methotrexate/misoprostol in clinical practice for abortion. Am J Obstet Gynecol. 188:2003;664-669.
5. He Q.J., Ying Y., Yang B., Fang R.Y. Synergistic effects of DL111-IT combined with mifepristone on termination of early pregnancy in rhesus monkeys. Contraception. 62:2000;189-193.
6. Yang B., Zhou H.J., He Q.J., Fang R.Y. Termination of early pregnancy in the mouse, rat and hamster with DL111-IT and RU486. Contraception. 62:2000;211-216.
7. Galliani G, Assandri A, Gallicol, et al. A new non-hormonal pregnancy-terminating agent. Contraception 1981;23:163-80.
8. Galliani G., Assandri A., Lerner L.J., et al. DL111, a new non-hormonal antifertility agent contragestational and kinetic profile in baboons . Contraception. 26:1982;165-179.
9. Yang B., Cao L., Fang R.Y., Gu Z.P. Effects of DL111-IT on progesterone biosynthesis and viability of rat luteal cells. Acta Pharmacol Sin. 18:1997;367-370.
10. Yang B., Cao L., Fang R.Y., Gu Z.P. Luteolytic effects of DL111-IT in pregnant rats. Eur J Pharmacol. 380:1999;145-152.
11. Yang B., Fang R.Y. Synergistic effects on pregnancy-termination activity of DL111-IT in combination with mifepristone. Acta Pharmacol Sin. 17:1996;361-365.
12. Avrech O.M., Golan A., Weintraub Z., et al. Mifepristone (RU486) alone or in combination with prostaglandin analogue for termination of early pregnancy a review . Fertil Steril. 56:1991;385-393.
13. Sermeus W., Delesie L. RIDIT analysis on ordinal data. West J Nurs Res. 18:1996;351-359.
14. Bliss C.I. The method of probits. Science. 79:1934;38-39.
15. DiPierri D. RU 486, mifepristone a review of a controversial drug . Nurse Pract. 19:1994;59-61.
16. Gold M., Luks D., Anderson M.R. Medical options for early pregnancy termination. Am Fam Physician. 56:1997;533-538.
17. Shentu J.Z., Zhou H.J., He Q.J., et al. Effects of DL111-IT or combined with RU486 on uterine polyamines biosynthesis in rats during early gestation. Contraception. 63:2001;283-287.