Mifepristone and misoprostol and methotrexate/misoprostol in clinical practice for abortion

American Journal of Obstetrics and Gynecology

Volumn 188, Issue 3, 2003, Pages 664-669

  Creinin, Mitchell D ^a   Potter, Cynthia ^a   Holovanisin, Maria ^a   Janczukiewicz, Lynn ^a   Pymar, Helen C ^a   Schwartz, Jill L ^a   Meyn, Leslie ^a  

^a UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

Author keywords

Medical abortion; Methotrexate; Mifepristone; Misoprostol

Indexed keywords

METHOTREXATE; MIFEPRISTONE; MISOPROSTOL;

ADULT; ARTICLE; BLEEDING; CHILL; CLINICAL PRACTICE; CONTROLLED STUDY; DIARRHEA; DRUG EFFICACY; FEMALE; FEVER; FOLLOW UP; GESTATIONAL AGE; HEADACHE; HEAT SENSATION; HUMAN; MAJOR CLINICAL STUDY; MUSCLE CRAMP; NAUSEA; PRIORITY JOURNAL; SIDE EFFECT; SPOTTING; THERAPEUTIC ABORTION; VERTIGO; VOMITING;

EID: 0037342595     PISSN: 00029378     EISSN: None     Source Type: Journal    
DOI: 10.1067/mob.2003.131     Document Type: Article

References (25)

1. Herndon J, Strauss LT, Whitehead S, Parker WY, Bartlett L, Zane S. Abortion surveillance: United States, 1998. MMWR Morb Mortal Wkly Rep 2002;51:1-32.
2. Aubény E, Peyron R, Turpin CL, Renault M, Targosz V, Silvestre L, et al. Termination of early pregnancy (up to 63 days of amenorrhea) with mifepristone and increasing closes of misoprostol. Int J Fertil Menopausal Stud 1995;40 (Suppl):85-91.
3. Creinin MD, Spitz IM. Use of various ultrasound criteria to evaluate the efficacy of mifepristone and misoprostol for medical abortion. Am J Obstet Gynecol 1999;181:1419-24.
4. Spitz IM, Bardin CW, Benton L, Robbins A. Early pregnancy termination with mifepristone and misoprostol in the United States. N Engl J Med 1998;338:1241-7.
5. World Health Organization Task Force on Post-ovulatory Methods of Fertility Regulation. Comparison of two doses of mifepristone in combination with misoprostol for early medical abortion: a randomised trial. Br J Obstet Gynaecol 2000;107:524-30.
6. Ashok PW, Penney GC, Flett GM, Templeton A. An effective regimen for early medical abortion: a report of 2000 consecutive cases. Hum Reprod 1998;13:2962-5.
7. Schaff EA, Eisinger SH, Stadalius LS, Franks P, Gore BZ, Poppema S. Low-dose mifepristone 200 mg and vaginal misoprostol for abortion. Contraception 1999;59:1-6.
8. Schaff E, Fielding S, Westhoff C, Ellertson C, Eisinger SH, Stadlius LS, et al. Vaginal misoprostol administered 1, 2, or 3 days after mifepristone for early medical abortion: a randomized trial. JAMA 2000;284:1948-53.
9. Schaff EA, Fielding SL, Eisinger SH, Stadalius LS, Fuller L. Low-dose mifepristone followed by vaginal misoprostol at 48 hours for abortion up to 63 days. Contraception 2000;61:41-6.
10. Pymar HC, Creinin MD, Schwartz JL. Mifepristone followed on the same day by vaginal misoprostol for early abortion. Contraception 2001;64:87-92.
11. El-Rafaey H, Rajasekar D, Abdalla M, Calder L, Templeton A. Induction of abortion with mifepristone (RU 486) and oral or vaginal misoprostol. N Engl J Med. 1995;332:983-7.
12. El-Refaey H, Templeton A. Early induction of abortion by a combination of oral mifepristone and misoprostol administered by the vaginal route. Contraception 1994;49:1114.
13. Pymar HC, Creinin MD. Alternatives to mifepristone regimens for medical abortion. Am J Obstet Gynecol 2000;183:S54-S64.
14. Schaff EA, Fielding SL, Westhoff C. Randomized trial of oral versus vaginal misoprostol at one day after mifepristone for early medical abortion. Contraception 2001;64:81-5.
15. Wiebe E, Dunn S, Guilbert E, Jacot F, Lugtig L. Comparison of abortions induced by methotrexate or mifepristone followed by misoprostol. Obstet Gynecol 2002;99:813-9.
16. Creinin MD, Schwartz JL, Pymar HC, Fink W. Efficacy of mifepristone followed on the same day by misoprostol for early termination of pregnancy: report of a randomised trial. Br J Obstet Gynaecol 2001;108:469-73.
17. Creinin MD, Pymar HC, Schwartz JL. Mifepristone 100 mg in abortion regimens. Obstet Gynecol 2001;98:454-9.
18. Fox MC, Creinin MD, Harwood B. Mifepristone and vaginal misoprostol on the same day for abortion from 50 to 63 days' gestation. Contraception 2002;66:225-9.
19. DiSaia PJ, Creasman WT. Clinical gynecologic oncology. St. Louis: Mosby; 1989.
20. Rosner B. Fundamentals of biostatistics. 4th ed. Harrisonburg (VA.): Wadsworth Publishing; 1995.
21. Creinin MD. Medical abortion with rnethotrexate 75 mg intramuscularly and vaginal misoprostol. Contraception 1997;56:367-71.
22. Creinin MD. Oral methotrexate and vaginal misoprostol for early abortion. Contraception 1996;54:15-8.
23. Creinin MD, Vittinghoff E, Schaff E, Klaisle C, Darney PD, Dean C. Medical abortion with oral methotrexate and vaginal misoprostol. Obstet Gynecol 1997;90:611-6.
24. Creinin MD. Randomized comparison of efficacy, acceptability and cost of medical versus surgical abortion. Contraception 2000;62:117-24.
25. Borgmann CE, Jones BS. Legal issues in the provision of medical abortion. Am J Obstet Gynecol 2000;183:S84-94.