Helicobacter pylori infection, vitamin B12 and homocysteine: A review

Digestive Diseases

Volumn 21, Issue 3, 2003, Pages 237-244

  Dierkes, Jutta ^a,b   Ebert, Matthias ^a   Malfertheiner, Peter ^a   Luley, Claus ^a  

^a UNIVERSITY HOSPITAL MAGDEBURG   (Germany)

^b Inst of Clin Chem/Biochemistry   (Germany)

Author keywords

Helicobacter pylori infection; Homocysteine; Pernicious anemia; Vitamin B12 deficiency

Indexed keywords

ANTIBIOTIC AGENT; CYANOCOBALAMIN; FOLIC ACID; GASTRIN; HOMOCYSTEINE; IMMUNOGLOBULIN G ANTIBODY;

AGE DISTRIBUTION; AMINO ACID BLOOD LEVEL; ANTIBIOTIC THERAPY; ANTIBODY BLOOD LEVEL; ATROPHIC GASTRITIS; BACTERICIDAL ACTIVITY; BACTERIUM DETECTION; BLOOD EXAMINATION; COHORT ANALYSIS; COMPARATIVE STUDY; CYANOCOBALAMIN DEFICIENCY; DIAGNOSTIC APPROACH ROUTE; DISEASE ASSOCIATION; FOLIC ACID BLOOD LEVEL; FOLLOW UP; GASTRIN BLOOD LEVEL; GEOGRAPHIC DISTRIBUTION; HELICOBACTER INFECTION; HELICOBACTER PYLORI; HOMOCYSTINURIA; HUMAN; MACROCYTIC ANEMIA; MALABSORPTION; OUTCOMES RESEARCH; PERNICIOUS ANEMIA; PRIORITY JOURNAL; REVIEW; SCHILLING TEST; SEROLOGY; STOMACH BIOPSY; STOMACH FUNCTION; VITAMIN BLOOD LEVEL;

ANEMIA, PERNICIOUS; GASTRITIS, ATROPHIC; HELICOBACTER INFECTIONS; HELICOBACTER PYLORI; HOMOCYSTEINE; HUMANS; INTESTINAL ABSORPTION; VITAMIN B 12; VITAMIN B 12 DEFICIENCY;

EID: 0142187703     PISSN: 02572753     EISSN: None     Source Type: Journal    
DOI: 10.1159/000073341     Document Type: Review

References (35)

1. Suerbaum S, Michetti P: Helicobacter pylori infection. N Engl J Med 2002;347:1175-1186.
2. Parsonnet J, Friedman GD, Vandersteen DP, Chang Y, Vogelman JH, Orentreich N, Sibley RK: Helicobacter pylori infection and the risk of gastric carcinoma. N Engl J Med. 1991;325(16):1127-1131.
3. Carmel R: Cobalamin, the stomach and aging. Am J Clin Nutr 1997;66:750-759.
4. Nexo E, Hansen M, Rasmussen K, Lindgren A, Grasbeck R: How to diagnose cobalamin deficiency. Scand J Clin Lab Invest Suppl 1994;219:61-76.
5. 12 deficiency. J Nutr 1996;126(suppl):1266-1272.
6. Bolann BJ, Solli JD, Schneede J, Grottum KA, Loraas A, Stokkeland M, Stallemo A, Schjoth A, Bie RB, Refsum H, Ueland PM: Evaluation of indicators of cobalamin deficiency defined as cobalamin-induced reduction in increased serum methylmalonic acid. Clin Chem 2000;46:1744-1750.
7. Holleland G, Schneede J, Ueland PM, Lund PK, Refsum H, Sandberg S: Cobalamin deficiency in general practice. Assessment of the diagnostic utility and cost-benefit analysis of methylmalonic acid determination in relation to current diagnostic strategies. Clin Chem 1999;45:189-198.
8. 12 concentration. Scand J Gastroenterol 1977;12:313-319.
9. Graham IM, O'Callaghan P: Vitamins, homocysteine and cardiovascular risk. Cardiovasc Drugs Ther 2002;16:383-389.
10. Pellicano R, Oliaro E, Gandolfo N, Aruta E, Mangiardi L, Orzan F, Bergerone S, Rizzetto M, Ponzetto A: Ischemic cardiovascular disease and Helicobacter pylori. Where is the link? J Cardiovasc Surg (Torino) 2000;41:829-833.
11. Fong TL, Dooley CP, Dehesa M, Cohen H, Carmel R, Fitzgibbons PL, Perez-Perez GI, Blaser MJ: Helicobacter pylori infection in pernicious anemia: A prospective controlled study. Gastroenterology 1991;100:328-332.
12. Haruma K, Komoto K, Kawaguchi H, Okamoto S, Yoshihara M, Sumii K, Kajiyama G: Pernicious anaemia and Helicobacter pylori infection in Japan: Evaluation in a country with a high prevalence of infection. Am J Gastroenterol 1995;90:1107-1110.
13. Marignani M, Delle Fave G, Mecarocci S, Bordi C, Angeletti S, D'Ambra G, Aprile MR, Corleto VD, Monarca B, Annibale B: High prevalence of atrophic body gastritis in patients with unexplained microcytic and macrocytic anaemia: a prospective screening study. Am J Gastroenterol 1999;94:766-772.
14. Annibale B, Negrini R, Caruana P, Lahner E, Grossi C, Bordi C, Delle Fave G: Two-thirds of atrophic body gastritis patients have evidence of Helicobacter pylori infection. Helicobacter 2001;6:225-233.
15. 12 and its carrier proteins in elderly patients. A study of 60 patients (in French). Rev Méd Interne 2003;24:218-223.
16. Annibale B, Lahner E, Bordi C, Martino G, Caruana P, Grossi C, Negrini R, Delle Fave G: Role of Helicobacter pylori infection in pernicious anaemia. Dig Liver Dis 2000;32:756-762.
17. 12 deficiency? Arch Intern Med 2000;160:1349-1353.
18. 12-deficiency anemia. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2001;92:166-169.
19. Ma JY, Borch K, Sjostrand SE, Janzon L, Mardh S: Positive correlation between H,K-adenosine triphosphatase autoantibodies and Helicobacter pylori antibodies in patients with pernicious anaemia. Scand J Gastroenterol 1994;29:961-965.
20. Kuipers EJ, Klinkenberg-Knol EC, Vandenbroucke-Grauls CM, Appelmelk BJ, Schenk BE, Meuwissen SG: Role of Helicobacter pylori in the pathogenesis of atrophic gastritis. Scand J Gastroenterol Suppl 1997;223:28-34.
21. Van Asselt DZ, de Groot LC, van Staveren WA, Blom HJ, Wevers RA, Biemond I, Hoefnagels WH: Role of cobalamin intake and atrophic gastritis in mild cobalamin deficiency in older Dutch subjects. Am J Clin Nutr 1998;68:328-334.
22. Pilott A, Fabrello R, Franceschi M, Scagnelli M, Soffiati F, Di Mario F, Fortunato A, Valerio G: Helicobacter pylori infection in asymptomatic elderly subjects living at home or in a nursing home: Effects on gastric function and nutritional status. Age Aging 1996;25:245-249.
23. Cenerelli S, Bonazzi P, Galeazzi R, Testa I, Bonfigli AR, Sirolla C, Giunta S, Galeazzi L, Fumelli D, Testa R: Helicobacter pylori masks differences in homocysteine plasma levels between controls and type 2 diabetic patients. Eur J Clin Invest 2002;32:158-162.
24. Bloemenkamp DG, Mali WP, Tanis BC, Rosendaal FR, van den Bosch MA, Kemmeren JM, Algra A, Visseren FL, van der Graaf Y: The relation between Helicobacter pylori and atherosclerosis cannot be explained by a high homocysteine concentration. Eur J Clin Invest 2002;32:549-555.
25. 12 levels in healthy adults. J Clin Gastroenterol 2003;36:130-133.
26. 12, folic acid and homocysteine levels in patients who underwent diagnostic coronary arteriography. Am J Gastroenterol 2002;97:861-866.
27. Cohen H, Weinstein WM, Carmel R: Heterogeneity of gastric histology and function in food cobalamin malabsorption: Absence of atrophic gastritis and achlorhydria in some patients with severe malabsorption. Gut 2000;47:638-645.
28. Carmel R, Aurangzeb I, Qian D: Associations of food-cobalamin malabsorption with ethnic origin, age, Helicobacter pylori infection, and serum markers of gastritis. Am J Gastroenterol 2001;96:63-70.
29. 12 deficiency in the absence of gastric atrophy. Helicobacter 2002;7:337-341.
30. Saxena V, Markus H, Swaminathan S, Mendall ME: Hyperhomocysteinaemia, Helicobacter pylori and coronary heart disease. Heart 1997;78:524.
31. Leung WK, Ma PK, Choi PC, Ching JY, Ng AC, Poon P, Woo KS, Sung JJ: Correlation between Helicobacter pylori infection, gastric inflammation and serum homocysteine concentration. Helicobacter 2001;6:146-150.
32. Yoshino N, Adachi K, Takashima T, Miyaoka Y, Yuki T, Ishihara S, Kinoshita Y: Helicobacter pylori infection does not affect the serum level of homocysteine. Am J Gastroenterol 2002;97:2927-2928.
33. Whincup P, Danesh J, Walker M, Lennon L, Thomson A, Appleby P, Hawkey C, Atherton J: Prospective study of potentially virulent strains of Helicobacter pylori and coronary heart disease in middle-aged men. Circulation 2000;101:1647-1652.
34. 12 malabsorption with antibiotics in atrophic gastritis. Gastroenterology 1991;101:1039-1045.
35. Russell RM, Krasinski SD, Samloff IM, Jacob RA, Hartz SC, Brovender SR: Folic acid malabsorption in atrophic gastritis. Possible compensation by bacterial folate synthesis. Gastroenterology 1986;91:1476-1482.