Loperamide increases glucose ultilization in streptozotocin-induced diabetic rats

Clinical and Experimental Pharmacology and Physiology

Volumn 30, Issue 10, 2003, Pages 734-738

  Tzeng, T F ^a   Liu, I M ^b   Lai, T Y ^c   Tsai, C C ^c   Chang, W C ^c   Cheng, J T ^d  

^a Pao Chien Hospital   (Taiwan)

^b TAJEN INSTITUTE OF TECHNOLOGY   (Taiwan)

^c CHINA MEDICAL UNIVERSITY   (Taiwan)

^d NATIONAL CHENG KUNG UNIVERSITY   (Taiwan)

Author keywords

GLUT 4; Intravenous glucose challenge test; Loperamide; Phosphoenolpyruvate carboxykinase; Streptozotocin diabetic rats

Indexed keywords

GLUCOSE; GLUCOSE TRANSPORTER 4; INSULIN; LOPERAMIDE; MESSENGER RNA; MU OPIATE RECEPTOR; PHOSPHOENOLPYRUVATE CARBOXYKINASE (GTP);

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DIABETES MELLITUS; GENE EXPRESSION; GLUCONEOGENESIS; GLUCOSE BLOOD LEVEL; GLUCOSE UTILIZATION; HORMONAL REGULATION; LIVER; MALE; NONHUMAN; NORTHERN BLOTTING; RAT; RECEPTOR DOWN REGULATION; SOLEUS MUSCLE; STREPTOZOCIN DIABETES; WESTERN BLOTTING;

ANIMALS; BLOOD GLUCOSE; DIABETES MELLITUS, EXPERIMENTAL; GLUCOSE TRANSPORTER TYPE 4; LOPERAMIDE; MALE; MONOSACCHARIDE TRANSPORT PROTEINS; MUSCLE PROTEINS; PROTEIN-SERINE-THREONINE KINASES; RATS; RATS, WISTAR; RNA, MESSENGER;

EID: 0142155037     PISSN: 03051870     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1440-1681.2003.03903.x     Document Type: Article

References (25)

1. Feldberg W, Smyth DG. C-Fragment of lipotropin: An endogenous potent analgesic peptide. Br. J. Pharmacol. 1977; 60: 445-53.
2. Curry DL, Li CH. Stimulation of insulin secretion by beta-endorphin (1-27 and 1-31). Life Sci. 1987; 40: 2053-8.
3. Locatelli A, Spotti D, Caviezel F. The regulation of insulin and glucagon secretion by opiates: A study with naloxone in healthy humans. Acta Diabetol. 1985; 22: 25-31.
4. Khawaja XZ, Green IC, Thorpe JR, Titheradge MA. The occurrence and receptor specificity of endogenous opioid peptides with pancreas and liver of the rat. Comparison with brain. Biochem. J. 1990; 267: 233-40.
5. Liu IM, Niu CS, Chi TC, Kuo DH, Cheng JT. Investigations of the mechanism of the reduction of plasma glucose by cold-stress in streptozotocin-induced diabetic rats. Neuroscience 1999; 92: 1137-42.
6. Lehmann KA. Tramadol for the management of acute pain. Drugs 1994; 47: 19-32.
7. Cheng JT, Liu IM, Chi TC, Tzeng TF, Lu FH, Chang CJ. Plasma glucose-lowering effect of tramadol in streptozotocin-induced diabetic rats. Diabetes 2001; 50: 2815-21.
8. Liu IM, Chi TC, Chen YC, Lu FH, Cheng JT. Activation of opioid μ-receptor by loperamide to lower plasma glucose in streptozotocin-induced diabetic rats. Neurosci. Lett. 1999; 265: 183-6.
9. Heel RC, Brogden RN, Speight TM, Avery GS. Loperamide: A review of its pharmacological properties and therapeutic efficacy in diarrhea. Drugs 1978; 15: 33-52.
10. Goodyear LJ, Hirshman MF, Smith RJ, Horton ES. Glucose transporter number, activity and isoform content in plasma membranes of red and white skeletal muscle. Am. J. Physiol. 1991; 261: E556-61.
11. Pessin JE, Bell GI. Mammalian facilitative glucose transporter family: Structure and molecular regulation. Annu. Rev. Physiol. 1992; 54: 911-30.
12. Attwood PA, Keech DB. Pyruvate carboxylase. Curr. Top. Cell. Regul. 1984; 23: 1-55.
13. Hanson RW, Reshef L. Regulation of phosphoenolpyruvate carboxykinase (GTP) gene expression. Annu. Rev. Biochem. 1997; 66: 581-611.
14. Liu IM, Chi TC, Hsu FL, Chen CF, Cheng JT. Isoferulic acid as active principle from the rhizoma of Cimicifugae dahurica to lower plasma glucose in diabetic rats. Planta Med. 1999; 65: 712-14.
15. Baron AD, Brechtel G, Wallace P, Edelman SV. Rates and tissue sites of non-insulin-and insulin-mediated glucose uptake in human. Am. J. Physiol. 1988; 255: E769-74.
16. Ziel FH, Venkatesan N, Davidson MB. Glucose transport is rate limiting for skeletal muscle glucose metabolism in normal and STZ-induced diabetic rats. Diabetes 1988; 37: 885-90.
17. Hollenbeck C, Reaven GM. Variations in insulin-stimulated glucose uptake in healthy individuals with normal glucose tolerance. J. Clin. Endocrinol. Metab. 1987; 64: 1169-73.
18. Berger J, Biswas C, Vicario PP, Strout HV, Saperstein R, Pilch PF. Decreased expression of the insulin-responsive glucose transporter in diabetes and fasting. Nature 1989; 340: 70-2.
19. Sivitz WI, Desautel SL, Kayano T, Bell GI, Pessin JE. Regulation of glucose transporter messenger RNA in insulin-deficient states. Nature 1989; 340: 72-4.
20. Henriksen EJ, Bourey RE, Rodnick KJ, Korany IL, Permutt MA, Holloszy JO. Glucose transporter protein content and glucose transport capacity in rat skeletal muscles. Am. J. Physiol. 1990; 259: E593-8.
21. Liu JP. Protein kinase C and its substrates. Mol. Cell. Endocrinol. 1996; 116: 1-29.
22. Mountjoy KG, Housey GM, Flier JS. Overproduction of the beta 1 form of protein kinase C enhances phorbol ester induction of glucose transporter mRNA. Mol. Endocrinol. 1989; 3: 2018-27.
23. Bollen M, Keppens S, Stalmans W. Specific features of glycogen metabolism in the liver. Biochem. J. 1998; 336: 1-31.
24. Consoli A, Nurjhan N, Capani F, Gerich J. Predominant role of gluconeogenesis in increased hepatic glucose production in NIDDM. Diabetes 1989; 38: 550-7.
25. Agati JM, Yeagley D, Quinn PG. Assessment of the roles of mitogen-activated protein kinase, phosphatidylinositol 3-kinase, protein kinase B, and protein kinase C in insulin inhibition of cAMP-induced phosphoenolpyruvate carboxykinase gene transcription. J. Biol. Chem. 1998; 273: 18 751-9.