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Volumn 302, Issue 5645, 2003, Pages 618-622

Experimental Models of Primitive Cellular Compartments: Encapsulation, Growth, and Division

Author keywords

[No Author keywords available]

Indexed keywords

ADSORPTION; CATALYSIS; CELLS; CLAY; ENCAPSULATION; EXTRUSION; FATTY ACIDS; MICELLES; POLYMERIZATION; RNA;

EID: 0142147270     PISSN: 00368075     EISSN: None     Source Type: Journal    
DOI: 10.1126/science.1089904     Document Type: Article
Times cited : (674)

References (37)
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    • 0142235816 scopus 로고    scopus 로고
    • note
    • The spontaneous self-assembly of vesicles can readily be observed by the addition of an alkaline solution of fatty acid micelles to a buffered solution at pH 8.5; during the course of the reaction, the turbidity of the solution increases as small 2- to 3-nm micelles (which scatter light very inefficiently) aggregate into patches of membrane and eventually into even larger vesicles of up to many microns (which scatter light much more effectively). This reaction has a long lag phase, but the reaction rate gradually increases due to the autocatalytic effect of preformed vesicles on the formation of new vesicles (36).
  • 19
    • 0142235817 scopus 로고    scopus 로고
    • note
    • Materials and methods are available as supporting material on Science Online.
  • 37
    • 0142235814 scopus 로고    scopus 로고
    • note
    • We thank A. Keefe, P. L. Luisi, B. Seelig, P.-A. Monnard, I. Chen, K. Ashtiani-Salehi, and A. Luptak for their helpful comments.on the manuscript and P. L. Luisi for helpful discussions and communication of results before publication. This work was supported by grants from the Human Frontier Science Program and the NASA Astrobiology Institute. M.M.H. was supported by an NIH National Research Service Award. S.M.F. was supported by a National Science Foundation Graduate Research Fellowship. J.W.S. is an Investigator of the Howard Hughes Medical Institute.


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.