Kinetics of C(2α)-proton abstraction from 2-benzylthiazolium salts leading to enamines relevant to catalysis by thiamin-dependent enzymes

Journal of the American Chemical Society

Volumn 119, Issue 10, 1997, Pages 2356-2362

  Barletta, Gabriel L ^a,b   Zou, Yu ^a   Huskey, W Phillip ^a   Jordan, Frank ^a  

^a RUTGERS UNIVERSITY   (United States)

^b UNIVERSITY OF PUERTO RICO   (Puerto Rico)

Author keywords

[No Author keywords available]

Indexed keywords

CARBOXYLYASE; QUATERNARY AMMONIUM DERIVATIVE;

ARTICLE; ENZYME ACTIVITY; ENZYME MECHANISM; IN VITRO STUDY; MODEL; NUCLEAR MAGNETIC RESONANCE; PROTON TRANSPORT; REACTION ANALYSIS;

EID: 0030960601     PISSN: 00027863     EISSN: None     Source Type: Journal    
DOI: 10.1021/ja9633528     Document Type: Article

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65. We cannot identify the peak at 2.4 ppm; it may arise from an impurity in the DCl solution used to acidify the sample, or it may be due to an unknown product formed once the acid is added. The latter possibility is considered unlikely since only a single unknown peak was observed. The remainder of the high-intensity peaks match the peaks seen in panel A.