Loss of Heterozygosity in the MXI1 Gene Is a Frequent Occurrence in Melanoma

Modern Pathology

Volumn 16, Issue 10, 2003, Pages 992-995

  Ariyanayagam Baksh, Shashi M ^a,b   Baksh, Fabien K ^a   Swalsky, Patricia A ^a   Finkelstein, Sydney D ^a  

^a UNIVERSITY OF PITTSBURGH MEDICAL CENTER   (United States)

^b LANCASTER GENERAL HOSPITAL   (United States)

Author keywords

Clonal diversity; Loss of heterozygosity; Melanoma; MTS1 CDKN2A; MXI1

Indexed keywords

ADULT; AGED; ALLELE; ARTICLE; CANCER GROWTH; CHROMOSOME 10Q; CHROMOSOME 9; CHROMOSOME DAMAGE; CHROMOSOME LOSS; CLINICAL ARTICLE; CLONE; CONTROLLED STUDY; FEMALE; GENETIC HETEROGENEITY; GENOTYPE; HETEROZYGOSITY LOSS; HUMAN; HUMAN TISSUE; MALE; MELANOMA; METASTASIS; MICROSATELLITE MARKER; MXI1 GENE; PRIORITY JOURNAL; TUMOR RECURRENCE; TUMOR SUPPRESSOR GENE;

ADULT; AGED; BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTORS; CHROMOSOMES, HUMAN, PAIR 10; CHROMOSOMES, HUMAN, PAIR 9; CLONE CELLS; DNA PRIMERS; DNA, NEOPLASM; DNA-BINDING PROTEINS; FEMALE; GENES, TUMOR SUPPRESSOR; GENOTYPE; HUMANS; LOSS OF HETEROZYGOSITY; MALE; MELANOMA; MICRODISSECTION; MICROSATELLITE REPEATS; MIDDLE AGED; NEOPLASM RECURRENCE, LOCAL; POLYMERASE CHAIN REACTION; SKIN NEOPLASMS; TRANSCRIPTION FACTORS; TUMOR SUPPRESSOR PROTEINS;

EID: 0142103688     PISSN: 08933952     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.MP.0000087421.44975.1C     Document Type: Article

References (15)

1. Albino AP. Genes involved in melanoma susceptibility and progression. Curr Opin Oncol 1995;7:162-9.
2. Greene MH. The genetics of hereditary melanoma and nevi. Cancer 1999;86:1644-57.
3. Isshiki K, Seng PA, Elder DE, Guerry D, Linnenbach AJ. Chromosome 9 deletion in sporadic and familial melanomas in vivo. Oncogene 1994;9:1649-53.
4. Healy E, Belgaid C, Takata M, Harrison D, Zhu NW, Burd DA, et al. Prognostic significance of allelic losses in primary melanoma. Oncogene 1998;16:2213-8.
5. Healy E, Rehman I, Angus P, Rees JL. Loss of heterozygosity in sporadic primary cutaneous melanoma. Genes Chromosomes Cancer 1995;12:152-6.
6. Morita R, Fujimoto A, Hatta N, Takehara K, Takata M. Comparison of genetic profiles between primary melanomas and their metastases reveals genetic alterations and clonal evolution during progression. J Invest Dermatol 1998;111:119-24.
7. Bogdan I, Xin H, Burg G, Boni R. Heterogeneity of allelic deletions within melanoma metastases. Melanoma Res 2001; 11:349-54.
8. Herbst RA, Weiss J, Ehnis A, Cavenee WK, Arden KC. Loss of heterozygosity for 10q22-10qter in malignant melanoma progression. Cancer Res 1994;54:3111-4.
9. Birck A, Ahrenkiel V, Zeuthen J, Hou-Jensen K, Guldberg P. Mutation and allelic loss of PTEN/MMAC1 gene in primary and metastatic melanoma biopsies. J Invest Dermatol 2000; 114:277-80.
10. Reifenberger J, Wolter M, Bostrom J, Buschges R, Schulte KW, Megahed M, et al. Allelic losses on chromosome arm 10q and mutation of the PTEN (MMAC1) tumour suppressor gene in primary and metastatic malignant melanomas. Virchows Arch 2000;436:487-93.
11. Rao UNM, Bakker A, Swalsky PA, Finkelstein SD. Max interacting protein 1: loss of heterozygosity is frequent in desmoplastic melanoma. Mod Pathol 1999;12:344-50.
12. Albarosa R, DiDonato S, Finocchiaro G. Redefinition of the coding sequence of the MXI1 gene and identification of a polymorphic repeat in the 3′non-coding region that allows the detection of loss of heterozygosity of chromosome 10q25 in glioblastomas. Hum Genet 1995;95:709-11.
13. Herbst R, Podewski EK, Mommert S, Kapp A, Weiss J. PTEN and MXI1 allelic loss on chromosome 10q is rare in melanoma in vivo. Arch Dermatol Res 1999;291:567-9.
14. Kounelis S, Jones MW, Papadaki H, Bakker A, Swalsky PA, Finkelstein SD. Carcinosarcomas (malignant mixed mullerian tumors) of the female genital tract: comparative molecular analysis of epithelial and mesenchymal components. Hum Pathol 1998;29:82-7.
15. Bussaglia E, Pujol RM, Gil MJ, Marti RM, Tuneu A, Febrer MI, et al. PTEN mutations in eight Spanish families and one Brazilian family with Cowden syndrome. J Invest Dermatol 2002;4:639-44.