Antioxidant, antidiabetic, antihyperlipidemic, reproduction stimulatory properties and safety of essential oil of Satureja Khuzestanica in rat in vivo: A toxicopharmacological study

Medical Science Monitor

Volumn 9, Issue 9, 2003, Pages

  Abdollahi, Mohammad ^a   Salehniam, Alinazar ^a   Reza Mortazavi, Seyed Hamid ^a   Ebrahimi, Mohsen ^a   Shafiee, Ahmad ^a   Fouladian, Fatemeh ^a   Keshavarz, Ketayoun ^a   Sorouri, Saheleh ^a   Khorasani, Reza ^a   Kazemi, Alireza ^a  

^a TEHRAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

Author keywords

Antioxidant power; Diabetes; Essential oil; Hyperlipidemia; Lipid peroxidation; Reproduction; Satureja Khuzestanica; Teratogenicity

Indexed keywords

ESSENTIAL OIL; GLUCOSE; SATUREJA KHUZESTANICA ESSENTIAL OIL; STREPTOZOCIN; TRIACYLGLYCEROL; UNCLASSIFIED DRUG;

ANALGESIC ACTIVITY; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIOXIDANT ACTIVITY; ANTISEPSIS; ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFECT; DRUG SAFETY; FEMALE; GLUCOSE BLOOD LEVEL; HYPERLIPIDEMIA; IN VIVO STUDY; IRAN; LD 50; LIPID PEROXIDATION; NONHUMAN; PREGNANCY; RAT; REPRODUCTION; STREPTOZOCIN DIABETES; TERATOGENICITY; TRADITIONAL MEDICINE; TRIACYLGLYCEROL BLOOD LEVEL;

ABNORMALITIES, DRUG-INDUCED; ANIMALS; ANTILIPEMIC AGENTS; ANTIOXIDANTS; BLOOD GLUCOSE; CHOLESTEROL; DOSE-RESPONSE RELATIONSHIP, DRUG; EMBRYONIC AND FETAL DEVELOPMENT; FEMALE; FETUS; HYPOGLYCEMIC AGENTS; LIPID PEROXIDATION; MALE; OILS, VOLATILE; PREGNANCY; RATS; RATS, SPRAGUE-DAWLEY; REPRODUCTION; SATUREJA; TRIGLYCERIDES;

EID: 0142090392     PISSN: 12341010     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (32)

1. th ed. Tehran University Publications, Tehran, 1990, pp. 42-45
2. El-Gazzar A, Watson L: A taxonomic study of Labiatae and related genera. New Phytologist, 1970; 69: 451-486
3. Slavkovska V, Jancic R, Bojovic S et al: Variability of essential oils of Satureja montana L. and Satureja kitaibelii wierzb, ex Heuff. from the central part of the Balkan peninsula. Phytochemistry, 2001: 57: 71-6
4. Abad MJ, Bermejo P, Gonzales E et al: Antiviral activity of Bolivian plant extracts. Gen Pharmacol, 1999; 32: 499-503
5. Hajhashemi V, Ghamladi A, Pezeshkian SK: Antinociceptive and anti-inflammatory effects of Satureja hortensis L. extracts and essential oil. J Ethnopharmacol, 2002; S2: 83-7
6. Azaz D, Demirci F, Satil F et al: Antimicrobial activity of some Satureja essential oils. Z Naturforsch, 2002; 57: 817-21
7. Sokovic M, Tzaknu O, Pitarokili D et al: Antifungal activities of selected aromatic plants growing wild in Greece. Nahrung, 2002; 46: 317-20
8. Yamasaki K, Nakano M, Kawahata T et al: Anti-HIV-1 activity of herbs in Labiatae. Biol Pharm Bull, 1998; 21: 829-33
9. Hajhashemi V, Sadraei H, Ghannadi AR et al: Antispasmodic and anti-diarrhoeal effect of Satureja hortensis, L. essential oil. J Ethnopharmacol, 2000; 71: 187-192
10. Sanchez de Rojas VR, Somoza B, Ortega T et al: Vasodilatory effect in rat aorta of eriodictyol obtained from Satureja obovata. Planta Med, 1999; 65: 234-8
11. Sanchez de Rojas VR, Somoza B et al: Isolation of vasodilatory active flavonoids from the traditional remedy Satureja obovata. Planta Med, 1996; 62: 272-4
12. Exarchou V, Nenadis N, Tsimidou M et al: Antioxidant activities and phenolic composition of extracts from Greek oregano, Greek sage, and summer savory. J Agric Food Chem, 2002: 50: 5294-9
13. Vardar-Unlu G, Candan F, Sokmen A et al: Antimicrobial and antioxidant activity of the essential oil and methanol extracts of Thymus pectinatus Fisch. et Mey. Var. pectinatus (Lamiaceae). J Agric Food Chem. 2003; 51: 63-7
14. Lambert RJ, Skandamis PN, Coote PJ et al: A study of the minimum inhibitory concentration and mode of action of oregano essential oil, thymol and carvacrol. J Appl Microbiol, 2001; 91: 453-62
15. Burits M, Bucar F: Antioxidant activity of Nigella sativa essential oil, Phytother Res, 2000: 14: 323-8
16. Heim KE, Tagliaferro AR, Bobilya DJ: Flavonoid antioxidants: chemistry, metabolism and structure-activity relationships. J Nutr Biochem, 2002; 13: 572-584
17. Andreassi MG: Coronary atherosclerosis and somatic mutations: an overview of the contributive factors for oxidative DNA damage. Mutat Res, 2003; 543: 67-86
18. Hasanain B, Monradian AD: Antioxidant vitamins and their influence in diabetes mellitus. Curr Diab Rep, 2002; 2: 448-56
19. Yagihashi S, Wada R, Yamagishi S: Diabetic microangiopathy: pathology and current understanding of its pathogenesis. Verb Dtsch Ges Pathol, 2002; 86: 91-100
20. Brown DJ, Goodman J: A review of vitamins A, C, and E and their relationship to cardiovascular disease. Clin Excell Nurse Pract, 1998; 2: 10-22
21. nd ed. New York: Rayen Press; 1988, p. 169-221
22. Satho K: Serum lipid peroxidation in cerebrovascular disorders determined by a new colorimetric method. Clin Chem Acta 1978; 90: 37-43
23. Iris F, Benzi F, Strain S: Ferric-reducing antioxidant assay. Method Enzymol, 1999; 292: 15-27
24. Mochizuki H, Takido J, Oda H et al: Improving effect of dietary taurine on marked hypercholesterolemia induced by a high-cholesterol diet in streptozotocin-induced diabetic rats. Biosci Biotechnol Biochem, 1999; 63(11): 1984-7
25. Mathe D: Dyslipidemia and diabetes: animal models. Diabetes and Metabolism (Paris), 1995; 21: 106-11
26. Kelly GE, Husband AJ: Flavonoid compounds in the prevention and treatment of prostate cancer. Methods Mol Med. 2003; 81: 377-94
27. Gomez E, Irvine DS, Aitken RJ: Evaluation of a spectrophotometric assay for the measurement of malondialdehyde and 4-hydroxyalkenals in human spermatozoa: relationships with semen quality and sperm function. Int J Androl, 1998; 21: 81-94
28. Tarin JJ, Perez-Albala S, Cano A: Oral antioxidants counteract the negative effects of female aging on oocyte quantity and quality in the mouse. Mol Reprod Dev, 2002; 61: 385-97
29. Karowicz-Bilińska A, Suzin J, Sieroszewski P: Evaluation of oxidative stress indices during treatment in pregnant women with intrauterine growth retardation. Med Sci Monit. 2002; 8(3): CR211-216
30. Sarkhail P, Abdollahi M, Shafiee A: Antinociceptive effect of Phlomis olivieri Benth, Phlomis anisodonta Boiss. and Phlomis persica Boiss. total extracts. Pharmacol Res, 2003; 48(3): 263-6
31. Abdollahi M, Karimpour H. Monsef-Esfahani HR: Antinociceptive effects of Teucrium polium L. total extract aud essential oil in mouse writhing test. Pharmacol Res, 2003; 48(1): 31-35
32. Abdollahi M, Jalali L, Salehi-Surmaghi MH: Antinociceptive effects of Achillea santolina L. on mouse formalin test. Biomed Res, 2002; 13(1): 53-56