A Novel Approach to Derive a Compression Parameter Indicating Effective Particle Deformability

Pharmaceutical Development and Technology

Volumn 8, Issue 4, 2003, Pages 367-377

  Alderborn, Göran ^a  

^a UPPSALA UNIVERSITY   (Sweden)

Author keywords

Compression parameter; Effective deformability; Hardness; Powder compactability; Tablet tensile strength; Yield strength

Indexed keywords

SODIUM CHLORIDE; SUCROSE;

ARTICLE; DERIVATIZATION; DRUG DETERMINATION; PARTICLE SIZE; PARTICULATE MATTER; POROSITY; POWDER; PRIORITY JOURNAL; TABLET COMPRESSION; TABLET HARDNESS; TABLET MANUFACTURE; TABLET THICKNESS; TENSILE STRENGTH;

COMPRESSIVE STRENGTH; DRUG COMPOUNDING; HARDNESS; PARTICLE SIZE; POWDERS; PRESSURE; SODIUM CHLORIDE; SUCROSE; SURFACE PROPERTIES; TABLETS;

EID: 0142062970     PISSN: 10837450     EISSN: None     Source Type: Journal    
DOI: 10.1081/PDT-120024690     Document Type: Article

References (17)

1. Mills, A.J.; Papadopoulos, D.G. Compaction simulation in tablet development. J. Pharm. Pharmacol. 2002, 54, S112-S113.
2. Fell, J.T.; Newton, J.M. Determination of tablet strength by the diametral compression test. J. Pharm. Sci. 1970, 59, 688-691.
3. Rowe, R.C.; Roberts, R.J. Mechanical properties. In Pharmaceutical Powder Compaction Technology; Alderborn, G., Nyström, C., Eds.; Marcel Dekker Inc.: New York, 1996; 283-322.
4. Paronen, P.; Illka, J. Porosity-pressure functions. In Pharmaceutical Powder Compaction Technology; Alderborn, G., Nyström, C., Eds.; Marcel Dekker Inc.: New York, 1996; 55-75.
5. Heckel, R.W. Density-pressure relationship in powder compaction. Trans. Metall. Soc. AIME 1961, 221, 671-675.
6. Sonnergaard, J.M. Investigation of a new mathematical model for compression of pharmaceutical powders. Eur. J. Pharm. Sci. 2001, 14, 149-157.
7. Denny, P.J. Compaction equations: a comparison of the Heckel and Kawakita equations. Powder Technol. 2002, 127, 162-172.
8. Michrafy, A.; Ringenbacher, D.; Tchoreloff, P. Modelling the compaction behaviour of powders: application to pharmaceutical powders. Powder Technol. 2002, 127, 257-266.
9. Eriksson, M.; Alderborn, G. The effect of particle fragmentation and deformation on the interparticulate bond formation process during powder compaction. Pharm. Res. 1995, 12, 1031-1039.
10. Sebhatu, T.; Alderborn, G. Relationships between the effective interparticulate contact area and the tensile strength of tablets of amorphous and crystalline lactose of varying particle size. Eur. J. Pharm. Sci. 1999, 8, 235-242.
11. Hardman, J.S.; Lilley, B.A. Mechanisms of compaction of powdered materials. Proc. R. Soc. Lond. 1973, A 333, 183-199.
12. Alderborn, G.; Duberg, M.; Nyström, C. Studies on direct compression of tablets X. Measurement of tablet surface area by permeametry. Powder Technol. 1985, 41, 49-56.
13. Adolfsson, A.; Nyström, C. Tablet strength, porosity and solid state structure of tablets compressed at high loads. Int. J. Pharm. 1996, 132, 95-106.
14. Newton, J.M.; Grant, D.J.W. The relation between the compaction pressure, porosity and tensile strength of compacted powders. Powder Technol. 1974, 9, 295-297.
15. Olsson, H.; Nyström, C. Assessing tablet bond types from structural features that affect tablet tensile strength. Pharm. Res. 2001, 18, 203-210.
16. Courtney, T.H. Mechanical Behaviour of Materials; McGraw-Hill Publishing Company: New York, 1990; 30-31.
17. Brandon, D.; Kaplan, W.D. Microstructural Characterization of Materials; John Wiley & Sons: Chichester, 1999; 1-12.