Glucose acts in the CNS to regulate gastric motility during hypoglycemia

American Journal of Physiology - Regulatory Integrative and Comparative Physiology

Volumn 285, Issue 5 54-5, 2003, Pages

  Shi, Min ^a   Jones, Allison R ^a   Niedringhaus, Mark S ^a   Pearson, Rebecca J ^a   Biehl, Ann M ^a   Ferreira Jr , Manuel ^a   Sahibzada, Niaz ^a   Verbalis, Joseph G ^a   Gillis, Richard A ^a  

^a GEORGETOWN UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

Antral motility; Central nervous system; Gastric tone; Insulin

Indexed keywords

BETHANECHOL; CAPSAICIN; GLUCOSE; INSULIN; PROTIRELIN DERIVATIVE; PROTIRELIN[3 (3,3 DIMETHYLPROLINAMIDE)];

ADOLESCENT; ANIMAL EXPERIMENT; ARTICLE; CENTRAL NERVOUS SYSTEM; EXPERIMENTAL MODEL; FORCE TRANSDUCER; GLUCOSE BLOOD LEVEL; GLUCOSE INFUSION; HYPOGLYCEMIA; MALE; NERVE BLOCK; NONHUMAN; PRIORITY JOURNAL; RAT; STOMACH ANTRUM; STOMACH MOTILITY; STOMACH PRESSURE; VAGOTOMY;

EID: 0142031625     PISSN: 03636119     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpregu.00179.2003     Document Type: Article

References (42)

1. Andrews JM, Rayner CK, Doran S, Hebbard GS, and Horowitz M. Physiological changes in blood glucose affect appetite and pyloric motility during intraduodenal lipid infusion. Am J Physiol Gastrointest Liver Physiol 275: G797-G804, 1998.
2. Bachrach WH. Action of insulin hypoglycemia on motor and secretory functions of the digestive tract. Physiol Rev 33: 566-592, 1953.
3. Barnett JL and Owyang C. Serum glucose concentration as a modulator of interdigestive gastric motility. Gastroenterology 94: 739-744, 1988.
4. Bellinger LL and Williams FE. The effects of liver denervation on food and water intake in the rat. Physiol Behav 26: 663-671, 1981.
5. Bjørnsson ES, Urbanavicius V, Eliasson B, Attvall S, Smith U, and Abrahamsson H. Effects of hyperglycemia on interdigestive gastrointestinal motility in humans. Scand J Gastroenterol 29: 1096-1104, 1994.
6. Brown Heller J and Taylor P. Muscarinic receptor agonists and antagonists. In: Goodman and Gillman's The Pharmacological Basis of Therapeutics (9th Ed.), edited by Hardman JG and Limbird LE. New York: McGraw-Hill, 1996, chapt. 7, p. 141-160.
7. Bulatao E and Carlson AJ. Contributions to the physiology of the stomach: influence of experimental changes in blood sugar level on gastric hunger contractions. Am J Physiol 69: 107-115, 1924.
8. deBoer SY, Maselee AAM, and Lamers CBHW. Effect of hyperglycemia on gastrointestinal and gallbladder motility. Scand J Gastroenterol 27, Suppl 194: 13-18, 1992.
9. Dunn-Meynell AA, Govek E, and Levin BE. Intracarotid glucose selectively increases Fos-like immunoreactivity in paraventricular, ventromedial and dorsomedial nuclei neurons. Brain Res 748: 100-106, 1997.
10. Ferreira M Jr, Browning KN, Sahibzada N, Verbalis JG, Gillis RA, and Travagli RA. Glucose effects on gastric motility and tone evoked from the rat dorsal vagal complex. J Physiol 536: 141-152, 2001.
11. Ferreira M Jr, Sahibzada N, Shi M, Panico W, Niedringhaus M, Wasserman A, Kellar K, Verbalis JG, and Gillis RA. CNS site of action and brainstem circuitry responsible for the intravenous effects of nicotine on gastric tone. J Neurosci 22: 2764-2779, 2002.
12. Ferreira M, Singh A, Dretchen KL, Kellar KJ, and Gillis RA. Brainstem nicotinic receptor subtypes that influence intragastric and arterial blood pressures. J Pharmacol Exp Ther 294: 230-233, 2000.
13. Fraser R, Horowitz M, and Dent J. Hyperglycemia stimulates pyloric motility in normal subjects. Gut 32: 475-478, 1991.
14. Hasler WL. The physiology of gastric motility and gastric emptying. In: Textbook of Gastroenterology (2nd Ed.), edited by Yamoda T. Philadelphia, PA: Lippincott, 1995, chapt. 8, p. 181-206.
15. Hasler WL, Soudak HC, Dulai G, and Owyang C. Mediation of hyperglycemia-evoked gastric slow-wave dysrhythmias by endogenous prostaglandins. Gastroenterology 108: 727-736, 1995.
16. Hebbard GS, Samsom M, Sun WM, Dent J, and Horowitz M. Hyperglycemia affects proximal gastric motor and sensory function during small intestinal triglyceride infusion. Am J Physiol Gastrointest Liver Physiol 271: G814-G819, 1996.
17. Hirano T and Niijima A. Effects of 2-deoxyglucoe, glucose and insulin on efferent activity in gastric vagus nerve. Experientia 36: 1197-1198, 1980.
18. Ishiguchi T, Nakojima M, Sone H, Tada H, Kumagai AK, and Takahashi T. Gastric distension-induced pyloric relaxation; central nervous system regulation and effects of acute hyperglycemia in the rat. J Physiol 533: 801-813, 2001.
19. Ishiguchi T, Tada H, Nakagawa K, Yamamura T, and Takahashi T. Hyperglycemia impairs antro-pyloric coordination and delays gastric emptying in conscious rats. Auton Neurosci 95: 112-120, 2002.
20. Ishikawa T, Yang H, and Taché Y. Medullary sites of action of the TRH analog, RX77368, for stimulation of gastric acid secretion in the rat. Gastroenterology 95: 1470-1476, 1988.
21. Jones KL, Kong MF, Berry MK, Rayner CK, Adamson U, and Horowitz M. The effect of erythromycin on gastric emptying is modified by physiological changes in the blood glucose concentration. Am J Gastroenterol 94: 2074-2079, 1999.
22. Kihara N, Fujimura M, Yamamoto I, Itoh E, Inui A, and Fujimya M. Effects of central and peripheral urocortin on fed and fasted gastroduodenal motor activity in conscious rats. Am J Physiol Gastrointest Liver Physiol 280: G406-G419, 2001.
23. Latour MG, Cardin S, Richard H, Yamagushi N, and Lavoie JM. Effect of hepatic vagotomy on plasma catecholamines during exercise-induced hypoglycemia. J Appl Physiol 78: 1629-1634, 1995.
24. McCann MJ, Hermann GE, and Rogers RC. Dorsal medullary serotonin and gastric motility: enhancement of effects by thyrotropin-releasing hormone. J Auton Nerv Syst 25: 35-40, 1988.
25. McCann MJ, Verbalis JG, and Stricker EM. Capsaicin pretreatment attenuates multiple responses to cholecystokinin in rats. J Auton Nerv Syst 23: 265-272, 1988.
26. Olson BR, Freilino M, Hoffman GE, Stricker EM, Sved AF, and Verbalis JG. c-Fos expression in rat brain and brainstem nuclei in response to treatments that alter food intake and gastric motility. Mol Cell Neurosci 4: 93-106, 1993.
27. Palkovits M, Mezey E, Eskay RL, and Brownstein MJ. Innervation of the nucleus of the solitary tract and dorsal vagal nucleus by thyrotropin-releasing hormone-containing raphe neurons. Brain Res 373: 246-251, 1986.
28. Paxinos G and Watson C. The Rat Brain in Stereotaxic Coordinates. Sydney: Academic, 1998.
29. Quigley JP and Templeton RD. Action of insulin on the motility of the gastrointestinal tract. IV. Action on the stomach following double vagotomy. Am J Physiol 91: 482-487, 1930.
30. Ritter RC and Landenheim EE. Capsaicin pretreatment attenuates suppression of food intake by cholecystokinin. Am J Physiol Regul Integr Comp Physiol 248: R501-R504, 1985.
31. Sakaguchi T and Shimojo E. Inhibition of gastric motility induced by hepatic portal injections of D-glucose and its anomers. J Physiol 351: 573-584, 1984.
32. Sakaguchi T, Taguchi T, and Okuda J. Different effects of D-glucose anomers on enhanced motility of the stomach. Biochem Int 7: 299-305, 1983.
33. Sakaguchi T and Yamaguchi K. Changes in efferent activities of the gastric vagus nerve by administration of glucose in the portal vein. Experientia 35: 875-876, 1979.
34. Samsom M, Akkermans LMA, Jebbink RJA, von Isselt H, VanBerge-Henegouwen GP, and Smout AJPM. Gastrointestinal motor mechanisms in hyperglycemia induced delayed gastric emptying in Type I diabetes mellitus. Gut 40: 641-646, 1997.
35. Saper CB, Loewy AD, Swanson LW, and Cowan WM. Direct hypothalamo-autonomic connections. Brain Res 117: 305-312, 1976.
36. Schwarcz E, Palmér M, Åman J, Horowitz M, Stridsberg M, and Berne C. Physiological hyperglycemia slows gastric emptying in normal subjects and patients with insulin-dependent diabetes mellitus. Gastroenterology 113: 60-66, 1997.
37. Steffens AB, Scheurink AJW, Porte D Jr, and Woods SC. Penetration of peripheral glucose and insulin into cerebrospinal fluid in rats. Am J Physiol Regul Integr Comp Physiol 255: R200-R204, 1988.
38. Thomas JE and Baldwin MV. Pathways and mechanisms of regulation of gastric motility. In: Handbook of Physiology. Alimentary Canal. Motility. Bethesda, MD: Am. Physiol. Soc., 1968, sect. 6, vol. IV, chapt. 95, p. 1937-1968.
39. Tordoff MG and Donald N. Celiac vagotomy attenuates the ingestive responses to epinephrine and hypertonic saline but not insulin, 2-deoxy-D-glucose, or polyethylene glycol. Physiol Behav 29: 605-613, 1982.
40. Verhagen MAMT, Rayner CK, Andrews JM, Hebbard GS, Doran SM, Samsom M, and Horowitz M. Physiological changes in blood glucose do not affect gastric compliance and perception in normal subjects. Am J Physiol Gastrointest Liver Physiol 276: G761-G766, 1999.
41. Yuan PQ and Yang H. Neuronal activation of brain vagal-regulatory pathways and upper gut enteric plexuses by insulin hypoglycemia. Am J Physiol Endocrinol Metab 283: E436-E448, 2002.
42. Zhou SY, Lu Y, and Owyang C. Gastric relaxation induced by hyperglycemia is mediated by vagal afferent pathways. Gastroenterology 122: A312-A313, 2002.