Plasma profiles of ivermectin in horses following oral or intramuscular administration

Journal of Veterinary Medicine Series A: Physiology Pathology Clinical Medicine

Volumn 50, Issue 6, 2003, Pages 297-302

  Perez R ^a   Godoy, C ^a   Palma, C ^a   Cabezas, I ^a   Munoz L ^a,d   Rubilar, L ^a   Arboix, M ^a,b   Alvinerie, M ^a,c  

^a UNIVERSITY OF CONCEPCIÓN   (Chile)

^b UNIVERSITAT AUTÒNOMA DE BARCELONA   (Spain)

^c CEMAGREF   (France)

^d NONE   (Chile)

Author keywords

[No Author keywords available]

Indexed keywords

EQUIDAE; EQUUS CABALLUS;

ANTHELMINTIC AGENT; IVERMECTIN;

ANIMAL; ANIMAL DISEASE; AREA UNDER THE CURVE; ARTICLE; BLOOD; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; FEMALE; HORSE; INTRAMUSCULAR DRUG ADMINISTRATION; MALE; METABOLISM; ORAL DRUG ADMINISTRATION; RANDOMIZED CONTROLLED TRIAL;

ADMINISTRATION, ORAL; ANIMALS; ANTHELMINTICS; AREA UNDER CURVE; FEMALE; HORSES; INJECTIONS, INTRAMUSCULAR; IVERMECTIN; MALE;

EID: 0142010056     PISSN: 0931184X     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1439-0442.2003.00531.x     Document Type: Article

References (31)

1. Ali, D. N., and D. R. Hennessy, 1996: The effect of level of feed intake on the pharmacokinetic disposition and efficacy of ivermectin in sheep. J. Vet. Pharmacol Therap. 19, 89-94.
2. Alvinerie, M., J. F. Sutra, I. Cabezas, L. Rubilar, and R. Pérez, 2000: Enhanced plasma availability of moxidectin in fasted horses. J. Equine Vet. Sci. 20, 575-578.
3. Alvinerie, M., J. F. Sutra, P. Galtier, and C. Mage, 1999: The pharmacokinetics of eprinomectin in plasma and milk following topical administration to lactating dairy cattle. Res. Vet. Sci. 67, 229-232.
4. Anderson, R. 1984: The use of ivermectin in horses: research and clinical observations. The Compendium on Continuing Education 6, S516-520.
5. Baggot, J. D., and Q. A. McKellar, 1994: The absorption, distribution and elimination of anthelmintic drugs: the role of pharmacokinetics. J. Vet. Pharmacol. Therap. 17, 409-419.
6. Campbell, W. C., and G. W. Benz, 1984: Ivermectin: a review of efficacy and safety. J. Vet. Pharmacol. Therap. 7, 1-16.
7. Campbell, W. C., W. H. D. Leaning, and R. L Seward, 1989: Use of ivermectin in horses. In: Campbell, W. C. (ed.), Ivermectin and Abamectin, pp. 234-244. Springer-Verlag, New York.
8. Conder, G. A., and W. C. Campbell, 1995: Chemotherapy of nematode infections of veterinary importance with special reference to drug resistance. Adv. Parasitol. 35, 1-70.
9. De Montigny, P., J. S. K. Shim, and J. V. Pivinichny, 1990: Liquid chromatographic determination of ivermectin in animal plasma with trifluoroacetic anhydride and N-methylimidazole as the derivatization reagent. J. Pharm. Biomed. Anal. 8, 507-511.
10. Di Pietro, J. A., D. E. Hutchens, T. F. Lock, K. Walker, A. J. Paul, C. Shipley, and D. Rulli, 1997: Clinical trial of moxidectin oral gel in horses. Vet. Parasitol. 72, 167-177.
11. Di Pietro, J. A., K. S. Todd, T. F. Lock, and T. A. Mc Pherron, 1982: Anthelmintic efficacy of ivermectin given intramuscularly in horses. Am. J. Vet. Res. 43, 145-148.
12. Dunsmore, J. D., 1985: Integrated control of Strogylus vulgaris infection in horses using ivermectin. Equine Vet. J. 17, 191-195.
13. Farrier, D., 1997: PK Solutions. Non Compartmental Pharmacokinetics Data Analysis. User Guide, pp. 50. Summit Research Services, Ashland, OH, USA.
14. Geary, T. G., S. M. Sims, E. M. Thomas, L. Vanover, J. P. Davis, C. A. Winterrowd, R. D. Klein, N. F. H. Ho, and D. P. Thompson, 1993: Haemonchus contortus: ivermectin-induced paralysis of the pharynx. Exp. Parasitol. 77, 88-96.
15. Jacobs, D. E., M. J. Hutchinson, L. Parker, and L. M. Gibbons, 1995: Equine cyathostome infection: suppression of fecal egg output with moxidectin. Vet. Record 137, 545.
16. Klei, T. R., M. R. Chapman, D. D. French, and H. W. Taylor, 1993: Evaluation of ivermectin at an elevated dose against encysted equine cyathostome larvae. Vet. Parasitol. 47, 99-106.
17. Klei, T., and B. J. Torbet, 1980: Efficacy of ivermectin (22,23-dihydroavermectin B1) against gastrointestinal parasites in ponies. Am. J. Vet. Res. 41, 1747-1750.
18. Lanusse, C., A. Lifschitz, G. Virkel, L. Alvarez, S. Sánchez, J. F. Sutra, P. Galtier, and M. Alvinerie, 1997: Comparative plasma disposition kinetics of ivermectin, moxidectin and doramectin in cattle. J. Vet. Pharmacol. Therap. 20, 91-99.
19. Lanusse, C., and R. K. Prichard, 1993: Relationship between pharmacological properties and clinical efficacy of ruminant anthelmintics. Vet. Parasitol. 49, 123-158.
20. Lifschitz, A., G. Virkel, A. Pis, F. Imperiale, S. Sánchez, L. Alvarez, R. Kujanek, and C. Lanusse, 1999: Ivermectin disposition kinetics after subcutaneous and intramuscular administration of an oil-based formulation to cattle. Vet. Parasitol. 86, 203-215.
21. Lo, P.-K. A., D. W. Fink, J. B. Williams, and J. Bloding, 1985: Pharmacokinetics studies of ivermectin: effects of formulation. Vet. Res. Commun. 9, 251-268.
22. Marriner, S. E., Y. McKinnon, and J. A. Bogan, 1987: The pharmacokinetics of ivermectin after oral and subcutaneous administration to sheep and horses. J. Vet. Pharmacol. Therap. 10, 175-179.
23. McKellar, Q. A., and H. A. Benchaoui, 1996: Avermectins and milbemycins. J. Vet. Pharmacol. Therap. 19, 331-351.
24. Nowakowski, M., M. Lynch, D. Smith, N. Logan, D. Mouzin, J. Lukaszewicz, N. Ryan, R. Hunter, and R. Jones, 1995: Pharmacokinetics and bioequivalence of parenterally administered doramectin in catlle. J. Vet. Pharmacol. Therap. 18, 290-298.
25. Pérez, R., I. Cabezas, M. Garcia, L. Rubilar, J. F. Sutra, P. Galtier, and M. Alvinerie, 1999: Comparison of the pharmacokinetics of moxidectin (Equest®) and ivermectin (Eqvalan®) in horses. J. Vet. Pharmacol. Therap. 22, 174-180.
26. Piché, C., M. J. Kennedy, H. A. Herbers, and K. M. Newcomb, 1991: Comparison of ivermectin, oxibendazole and pyrantel pamoate in suppressing fecal egg output in horses. Can. Vet. J. 32, 104-107.
27. Pulliam, J. D., and J. M. Preston, 1989: Safety of ivermectin in target animals. In: Campbell, W. (ed.), Ivermectin and Abamectin, pp. 149-161. Springer-Verlag, New York, USA.
28. Riviere, J. E., 1999: Comparative Pharmacokinetics: Principles, Techniques and Applications, pp. 148-167. Iowa State University Press, Ames, Iowa.
29. Scott, E. W., and Q. A. Mckellar, 1992: The distribution and some pharmacokinetic parameters of ivermectin in pigs. Vet. Res. Commun. 16, 139-146.
30. Sklavounos, C., N. Dmers, Lukaszewicks, and M. Nowakowski, 1994: Photoisomerization of aromatic doramectin derivatives. J. Agricult. Food Chem. 42, 1228-1231.
31. Zajac, A. M., 1994: Fecal examination in the diagnosis of parasitism. In: Sloss, M. W., R. L. Kemp, and A. M. Zajac (eds), Veterinary Clinical Parasitology, 6th edn, pp. 3-93. Iowa State University Press, Ames, Iowa.