Advanced glycation end-products pentosidine and NE-carboxymethyllysine are elevated in serum of patients with osteoporosis

Rheumatology

Volumn 42, Issue 10, 2003, Pages 1242-1246

  Hein, Gert ^a   Wiegand, R ^a   Lehmann, G ^a   Stein, G ^a   Franke, S ^a  

^a FRIEDRICH SCHILLER UNIVERSITY JENA   (Germany)

Author keywords

Advanced glycation end product; Bone formation; Bone histomorphometry; Bone resorption; NE carboxymethyllysine; Osteoporosis; Pentosidine

Indexed keywords

6 N CARBOXYMETHYLLYSINE; ADVANCED GLYCATION END PRODUCT; BIOLOGICAL MARKER; MINERAL; PENTOSIDINE;

ADULT; AGED; AGING; ARTICLE; BLOOD LEVEL; BLOOD SAMPLING; BONE REMODELING; BONE TURNOVER; CELL ACTIVITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; CORRELATION FUNCTION; DATA ANALYSIS; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; MAJOR CLINICAL STUDY; MALE; MEASUREMENT; MORPHOMETRICS; OSTEOCLAST; OSTEOLYSIS; OSTEOPOROSIS; PATIENT CODING; PRIORITY JOURNAL; TRABECULAR BONE;

ADULT; AGED; ANALYSIS OF VARIANCE; ARGININE; BONE RESORPTION; FEMALE; GLYCOSYLATION END PRODUCTS, ADVANCED; HUMANS; LYSINE; MALE; MIDDLE AGED; OSTEOPOROSIS;

EID: 0141997270     PISSN: 14620324     EISSN: None     Source Type: Journal    
DOI: 10.1093/rheumatology/keg324     Document Type: Article

References (18)

1. Thornalley PJ. Cell activation by glycated proteins. AGE receptors, receptor recognition factors and functional classification of AGEs. Cell Mol Biol (Noisy-le-grand) 1998;44:1013-23.
2. Singh R, Barden A, Mori T, Beilin L. Advanced glycation end-products: a review. Diabetologia 2001;44: 129-46.
3. Raj DS, Choudhury D, Welbourne TC, Levi M. Advanced glycation end products: a nephrologist's pespective. Am J Kidney Dis 2000;35:365-80.
4. Colaco CALS, Ledesma MD, Harrington CR, Avila J. The role of the Maillard reaction in other pathologies: Alzheimer's disease. Nephrol Dial Transplant 1996; 11(Suppl. 5):7-12.
5. Takahashi M, Suzuki M, Kushida K, Miyamoto S, Inoue T. Relationship between pentosidine levels in serum and urine and activity in rheumatoid arthritis. Br J Rheumatol 1997;36:637-42.
6. Miyata T, Ishiguro N, Yasuda Y et al. Increased pentosidine, an advanced glycation end product, in plasma and synovial fluid from patients with rheumatoid arthritis and its relation with inflammatory markers. Biochem Biophys Res Commun 1998;244:45-9.
7. Chen JR, Takahashi M, Suzuki M, Kushida K, Miyamoto S, Inoue T. Comparison of the concentrations of pentosidine in the synovial fluid, serum and urine of patients with rheumatoid arthritis and osteoarthritis. Rheumatology 1999;38:1275-8.
8. Hein G, Franke S. Are advanced glycation end-product-modified proteins of pathogenetic importance in fibromyalgia? Rheumatology 2002;41:1163-7.
9. E-carboxymethyllysine in the synovial tissue of patients with rheumatoid arthritis. Ann Rheum Dis 2002; 61:488-92.
10. Miyata T, Ueda Y, Shinzato T et al. Accumulation of albumin-linked and free-form pentosidine in the circulation of uremic patients with end-stage renal failure: Renal implications in the pathophysiology of pentosidine. J Am Soc Nephrol 1996;7:1198-206.
11. Misselwitz J, Franke S, Kauf E, John U, Stein G. Advanced glycation endproducts in children with chronic renal failure and type I diabetes. Pediatr Nephrol 2002;17:316-21.
12. Eriksen EF, Axelrod DW, Melsen F, eds. Bone histomorphometry. Research, American Society of Bone and Mineral Research). New York: Raven Press, 1994: 33-48.
13. Marie PJ, Sabbagh A, de Vernejoul MC, Lomri A. Osteocalcin and deoxyribonucleic acid synthesis in vitro and histomorphometric indices of bone formation in postmenopausal osteoporosis. J Clin Endocrinol Metab 1989;69:272-9.
14. Miyata T, Notoya K, Yoshida K et al. Advanced glycation end products enhance osteoclast-induced bone resorption in cultured mouse unfractionated boric cells and in rats implanted subcutaneously with devitalized bone particles. J Am Soc Nephrol 1997;8:260-70.
15. McCarthy AD, Etcheverry SB, Cortizo AM. Effect of advanced glycation endproducts on the secretion of insulin-like growth factor-I and its binding proteins: role in osteoblast development. Acta Diabetol 2001; 38:113-22.
16. McCarthy AD, Etcheverry SB, Bruzzone L, Lettieri G, Barrio DA, Cortizo AM. Non-enzymatic glycosylation of a type I collagen matrix: effects on osteoblastic development and oxidative stress. BMC Cell Biol 2001;2:16.
17. Yamamoto T, Ozono K, Miyauchi A et al. Role of advanced glycation end products in adynamic bone disease in patients with diabetic nephropathy. Am J Kidney Dis 2001;38(Suppl. 1):S161-4.
18. McCarthy AD, Etcheverry SB, Bruzzone SB, Cortizo AM. Advanced glycation endproduct-specific receptors in rat mouse osteoblast-like cells: regulation with stages of differentiation. Acta Diabetol 1999;36:45-52.