Evidence of a substantial genetic basis for IgG2 levels in families with aggressive periodontitis

Journal of Dental Research

Volumn 82, Issue 9, 2003, Pages 708-712

  Diehl, S R ^a   Wu, T ^a   Burmeister, J A ^b   Califano, J V ^b   Brooks, C N ^b   Tew, J G ^b   Schenkein, H A ^b  

^a RUTGERS SCHOOL OF DENTAL MEDICINE   (United States)

^b VIRGINIA COMMONWEALTH UNIVERSITY   (United States)

Author keywords

Antibody response; Genetic correlation; Heritability; Host susceptibility; Variance components

Indexed keywords

IMMUNOGLOBULIN G;

ADOLESCENT; ADULT; AGE; AGED; ARTICLE; CAUCASIAN; FEMALE; GENETIC PREDISPOSITION; GENETIC VARIABILITY; GENETICS; HUMAN; IMMUNOLOGY; MALE; MIDDLE AGED; NEGRO; PERIODONTAL DISEASE; PERIODONTITIS; RISK FACTOR; SMOKING;

ADOLESCENT; ADULT; AFRICAN CONTINENTAL ANCESTRY GROUP; AGE FACTORS; AGED; EUROPEAN CONTINENTAL ANCESTRY GROUP; FEMALE; GENETIC PREDISPOSITION TO DISEASE; HUMANS; IMMUNOGLOBULIN G; MALE; MIDDLE AGED; PERIODONTAL ATTACHMENT LOSS; PERIODONTITIS; RISK FACTORS; SMOKING; VARIATION (GENETICS);

EID: 0141990611     PISSN: 00220345     EISSN: None     Source Type: Journal    
DOI: 10.1177/154405910308200910     Document Type: Article

References (30)

1. Albandar JM, Rams TE (2002). Risk factors for periodontitis in children and young persons. Periodontol 2000 29:207-222.
2. Albandar JM, DeNardin AM, Adesanya MR, Diehl SR, Winn DM (2001). Associations between serum antibody levels to periodontal pathogens and early-onset periodontitis. J Periodontol 72:1463-1469.
3. Albandar JM, DeNardin AM, Adesanya MR, Winn DM, Diehl SR (2002). Associations of serum concentrations of IgG, IgA, IgM and interleukin-1beta with early-onset periodontitis classification and race. J Clin Periodontol 29:421-426.
4. Almasy L, Blangero J (1998). Multipoint quantitative-trait linkage analysis in general pedigrees. Am J Hum Genet 62:1198-1211.
5. Blangero J, Williams JT, Almasy L (2001). Variance component methods for detecting complex trait loci. Adv Genet 42:151-181.
6. Califano JV, Gunsolley JC, Nakashima K, Schenkein HA, Wilson ME, Tew JG (1996). Influence of anti-Actinobacillus actinomycetemcomitans Y4 (serotype b) lipopolysaccharide on severity of generalized early-onset periodontitis. Infect Immun 64:3908-3910.
7. Califano JV, Pace BE, Gunsolley JC, Schenkein HA, Lally ET, Tew JG (1997). Antibody reactive with Actinobacillus actinomycetemcomitans leukotoxin in early-onset periodontitis patients. Oral Microbiol Immunol 12:20-26.
8. Choi JI, Ha MH, Kim JH, Kim SJ (1996). Immunoglobulin allotypes and immunoglobulin G subclass responses to Actinobacillus actinomycetemcomitans and Porphyromonas gingivalis in early-onset periodontitis. Infect Immun 64:4226-4230.
9. Colombo AP, Eftimiadi C, Haffajee AD, Cugini MA, Socransky SS (1998). Serum IgG2 level, Gm(23) allotype and FcgammaRIIa and FcgammaRIIIb receptors in refractory periodontal disease. J Clin Periodontol 25:465-474.
10. Craig RG, Boylan R, Yip J, Mijares D, Imam M, Socransky SS, et al. (2002). Serum IgG antibody response to periodontal pathogens in minority populations: relationship to periodontal disease status and progression. J Periodontal Res 37:132-146.
11. Diehl SR, White PS (2001). Cambridge Healthtech Institute's Third Annual Conference on human genetic variation. Pharmacogenomics 2:79-84.
12. Diehl SR, Wang Y, Brooks CN, Burmeister JA, Califano JV, Wang S, et al. (1999). Linkage disequilibrium of interleukin-1 genetic polymorphisms with early-onset periodontitis. J Periodontol 70:418-430.
13. Gunsolley JC, Pandey JP, Quinn SM, Tew J, Schenkein HA (1997). The effect of race, smoking and immunoglobulin allotypes on IgG subclass concentrations. J Periodontal Res 32:381-387.
14. Haffajee AD, Socransky SS (1994). Microbial etiological agents of destructive periodontal diseases. Periodontol 2000 5:78-111.
15. Lehner T, Wilton JM, Ivanyi L, Manson JD (1974). Immunological aspects of juvenile periodontitis (periodontosis). J Periodontal Res 9:261-272.
16. Li MD, Cheng R, Ma JZ, Swan GE (2003). A meta-analysis of estimated genetic and environmental effects on smoking behavior in male and female adult twins. Addiction 98:23-31.
17. Lu H, Califano JV, Schenkein HA, Tew JG (1993). Immunoglobulin class and subclass distribution of antibodies reactive with the immunodominant antigen of Actinobacillus actinomycetemcomitans serotype b. Infect Immun 61:2400-2407.
18. Lu H, Wang M, Gunsolley JC, Schenkein HA, Tew JG (1994). Serum immunoglobulin G subclass concentrations in periodontally healthy and diseased individuals. Infect Immun 62:1677-1682.
19. Marazita ML, Lu H, Cooper ME, Quinn SM, Zhang J, Burmeister JA, et al. (1996). Genetic segregation analyses of serum IgG2 levels. Am J Hum Genet 58:1042-1049.
20. Mathias RA, Freidhoff LR, Blumenthal MN, Meyers DA, Lester L, King R, et al. (2001). Genome-wide linkage analyses of total serum IgE using variance components analysis in asthmatic families. Genet Epidemiol 20:340-355.
21. Mooney J, Hodge PJ, Kinane DF (2001). Humoral immune response in early-onset periodontitis: influence of smoking. J Periodontal Res 36:227-232.
22. Offenbacher S (1996). Periodontal diseases: pathogenesis. Ann Periodontol 1:821-878.
23. Quinn SM, Zhang JB, Gunsolley JC, Schenkein JG, Schenkein HA, Tew JG (1996). Influence of smoking and race on immunoglobulin G subclass concentrations in early-onset periodontitis patients. Infect Immun 64:2500-2505.
24. Quinn SM, Zhang JB, Gunsolley JC, Schenkein HA, Tew JG (1998). The influence of smoking and race on adult periodontitis and serum IgG2 levels. J Periodontol 69:171-177.
25. Schenkein HA (2002). Finding genetic risk factors for periodontal diseases: is the climb worth the view? Periodontol 2000 30:79-90.
26. Siber GR, Santosham M, Reid GR, Thompson C, Almeido-Hill J, Morell A, et al. (1990). Impaired antibody response to Haemophilus influenzae type b polysaccharide and low IgG2 and IgG4 concentrations in Apache children. N Engl J Med 323:1387-1392.
27. Tangada SD, Califano JV, Nakashima K, Quinn SM, Zhang JB, Gunsolley JC, et al. (1997). The effect of smoking on serum IgG2 reactive with Actinobacillus actinomycetemcomitans in early-onset periodontitis patients. J Periodontol 68:842-850.
28. Waldrop TC, Mackler BF, Schur P (1981). IgG and IgG subclasses in human periodontosis (juvenile periodontitis). Serum concentrations. J Periodontol 52:96-98.
29. Wilson ME, Hamilton RG (1992). Immunoglobulin G subclass response of localized juvenile periodontitis patients to Actinobacillus actinomycetemcomitans Y4 lipopolysaccharide. Infect Immun 60:1806-1812.
30. Zhang JB, Quinn SM, Rausch M, Gunsolley JC, Schenkein HA, Tew JG (1996). Hyper-immunoglobulin G2 production by B cells from patients with localized juvenile periodontitis and its regulation by monocytes. Infect Immun 64:2004-2009.