A Predictive Aggregate Transport Model for Microfiltration of Combined Macromolecular Solutions and Poly-Disperse Suspensions: Testing Model with Transgenic Goat Milk

Biotechnology Progress

Volumn 19, Issue 5, 2003, Pages 1533-1540

  Baruah, Gautam Lal ^a   Couto, Daniel ^b   Belfort, Georges ^a  

^a Rensselaer Polytechnic Institute   (United States)

^b GTC Biotherapeutics Inc   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MACROMOLECULES; MICROFILTRATION; PROTEINS; SOLUTIONS; SUSPENSIONS (FLUIDS);

PREDICTIVE AGGREGATE TRANSPORT MODEL;

BIOTECHNOLOGY;

ANIMALS; COMPLEX MIXTURES; COMPUTER SIMULATION; GOATS; IMMUNOGLOBULIN G; MACROMOLECULAR SUBSTANCES; MEMBRANES, ARTIFICIAL; MICROFLUIDICS; MILK; MODELS, CHEMICAL; MOTION; PARTICLE SIZE; PERMEABILITY; POROSITY; SHEAR STRENGTH; SOLUTIONS; SUSPENSIONS; ULTRAFILTRATION;

ANIMALIA; CAPRA HIRCUS;

EID: 0141977184     PISSN: 87567938     EISSN: None     Source Type: Journal    
DOI: 10.1021/bp030010e     Document Type: Article

References (24)

1. Kreeger, K. Y. Transgenic mammals likely to transform drug making. Scientist 1997, 11 (15).
2. Baruah, G. L.; Belfort, G. A predictive aggregate transport model for microfiltration of combined macromolecular solutions and poly-disperse suspensions: model development. Biotechnol. Progress 2003, 19, 1524-1532.
3. Pollock, D. P.; Kutzko, J. P.; Birck-Wilson, E.; Williams, J. L.; Echelard, Y.; Meade, H. M. Transgenic milk as a method for the production of recombinant antibodies. J. Immunol. Methods 1999, 231, 147-157.
4. Prunkard, D.; Cottingham, I.; Garner, I.; Bruce, S.; Dalrymple, M.; Lasser, G.; Bishop, P.; Foster, D. High-level expression of recombinant human fibrinogen in the milk of transgenic mice. Nat. Biotechnol. 1996, 14, 867.
5. Mckee, C.; Gibson, A.; Dalrymple, M.; Emslie, L.; Garner, I.; Cottingham, I. Production of biologically active salmon calcitonin in the milk of transgenic rabbits. Nat. Biotechnol. 1998, 16, 647.
6. John, D. C. A.; Watson, R.; Kind, A. J.; Scott, A. R.; Kadler, K. E.; Bulleid, N. J. Expression of an engineered form of recombinant procollagen in mouse milk. Nat. Biotechnol. 1999, 17, 385-389.
7. Dairy Processing Handbook; Tetra Pak Processing Systems AB: Lund, Sweden, 1995.
8. Morcol, T.; He, Q.; Bell, S. J. D. Model process for removal of caseins from milk of transgenic animals. Biotechnol. Prog. 2001, 17, 577-582.
9. Gardner, T. C.; Velander, W. H. Delipidation treatments for large scale protein purification processing. Master's Thesis, Virginia Polytechnic Institute and State University, 1998.
10. Meade, H. M.; Echelard, Y.; Ziomek, C. A.; Young, M. W.; Harvey, M.; Cole, E. S.; Groet, S.; Smith, T. E.; Curling, J. M. Gene Expression Systems: Using Nature for the Art of Expression; Academic Press: New York 1999; pp 399-427.
11. Denman, J. S.; Cole, E. S. Isolation of components of interest from milk. U.S. Patent 5,756,687, 1995.
12. Morcol, T.; Bell, S. J. D. Method for processing milk. U.S. Patent 6,183,803, 2001.
13. Goff, H. D.; Hill, A. R. Dairy chemistry and physics. In Dairy Science and Technology Handbook, Vol. 1, Principles and Properties; Hui, Y. H., Ed.; VCH: New York, 1993; Chapter 1, pp 1-81.
14. Walstra, P. Casein sub-micelle: do they exist? Int. Dairy J. 1999, 9, 189-192.
15. McMahon, D. J.; McManus, W. R. Rethinking casein micelle structure using electron microscopy. J. Dairy Sci. 1998, 81, 2985-2993.
16. Nagata, N.; Herouvis, K. J.; Dziewulski, D. M.; Belfort, G. Cross-flow membrane microfiltration of a bacterial fermentation broth. Biotechnol. Bioeng. 1988, 34, 447-466.
17. Luque, S.; Mallubhotla, H.; Gehlert, G.; Kuriyel, R.; Dzengeleski, S.; Pearl, S.; Belfort, G. A new coiled hollow-fiber module design for enhanced microfiltration performance in biotechnology. Biotechnol. Bioeng. 1999, 65, 247-257.
18. Belfort, G.; Davis, R. H.; Zydney, A. L. The behavior of suspensions and macromolecular solutions in crossflow microfiltration. J. Membr. Sci. 1994, 96, 1-58.
19. Belfort, G. Coiled membrane filtration system. U.S. Patent RE 37,759, 2002.
20. Zeman, L. J.; Zydney, A. L. Microfiltration and Ultrafiltration Principles and Applications; Marcel Dekker: New York, 1996.
21. Field, R. W.; Wu, D.; Howell, J. A.; Gupta, B. B. Critical flux concept for microfiltration fouling. J. Membr. Sci. 1994, 100, 259-272.
22. Gesan-Guiziou, G.; Daufin, G.; Boyaval, E. Critical stability conditions in skimmed milk crossflow microfiltration: impact on operating modes. Lait 2000, 80, 129-140.
23. Ould-Dris, A.; Jaffrin, M. Y.; Si-Hassen, D.; Neggaz, Y. Effect of cake thickness and particle polydispersity on prediction of permeate flux in microfiltration of particulate suspensions by a hydrodynamic diffusion model. J. Membr. Sci. 2000, 164, 211-227.
24. Al-Akoum, O.; Mercier-Bonin, M.; Ding, L.; Fonade, C.; Aptel, P.; Jaffrin, M. Hydrodynamic characterization and comparison of three particular systems used for flux enhancement: Application to crossflow filtration of a yeast suspension. ICOM oral. 2002, 573.