Mechanically altered embryonic chicken endothelial cells change their phenotype to an epithelioid phenotype

Anatomical Record - Part A Discoveries in Molecular, Cellular, and Evolutionary Biology

Volumn 270, Issue 1, 2003, Pages 67-81

  Arciniegas, Enrique ^a   Parada, David ^b   Graterol, Armando ^a  

^a INSTITUTO DE BIOMEDICINA   (Venezuela)

^b Hospital Vargas de Caracas   (Venezuela)

Author keywords

Aorta; bFGF; Epithelioid cells; Mesenchymal cells; Re endothelialization; Smooth muscle actin; TGF

Indexed keywords

ALPHA ACTIN; BASIC FIBROBLAST GROWTH FACTOR; TRANSFORMING GROWTH FACTOR BETA2; TRANSFORMING GROWTH FACTOR BETA3; VON WILLEBRAND FACTOR;

ANIMAL CELL; ARTERY INTIMA PROLIFERATION; ARTICLE; CELL DIFFERENTIATION; CELL SHAPE; CELL SIZE; CHICK EMBRYO; CONTROLLED STUDY; EMBRYO; EMBRYO CELL; ENDOTHELIUM CELL; EPITHELIOID CELL; IMMUNOREACTIVITY; MESENCHYME; MICROSCOPY; MONOLAYER CULTURE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; VIDEORECORDING; WOUND CLOSURE;

GALLUS GALLUS;

EID: 0141963312     PISSN: 0003276X     EISSN: None     Source Type: Journal    
DOI: 10.1002/ar.a.10177     Document Type: Article

References (69)

1. Acevedo AD, Bowser SS, Gerritsen ME, Bizios R. 1993. Morphological and proliferative responses of endothelial cells to hydrostatic pressure: role of fibroblast growth factor. J Cell Physiol 157:603-614.
2. Adams LD, Lemire JM, Schwartz SM. 1999. A systematic analysis of 40 random genes in cultured vascular smooth muscle subtypes reveals a heterogeneity of gene expression and identifies the tight junction gene zonula occludens as a marker of epithelioid "pup" smooth muscle cells and a participant in carotid neointimal formation. Arterioscler Thromb Vasc Biol 19:2600-2608.
3. Akong TA, Gotlieb AI. 1999. Reduced in vitro repair in endothelial cells harvested from the intercostal ostia of porcine thoracic aorta. Arterioscler Thromb Vasc Biol 19:665-671.
4. Arciniegas E, Servin M, Arguello C, Mota M. 1989. Development of the aorta in the chicken embryo: structural and ultrastructural study. Atherosclerosis 76:219-235.
5. Arciniegas E, Sutton AB, Allen TD, Schor AM. 1992. Transforming growth factor beta-1 promotes the differentiation of endothelial cells into smooth muscle-like cells in vitro. J Cell Sci 103:521-529.
6. Arciniegas E, Ponce L, Hartt Y, Graterol A, Carlini RG. 2000. Intimal thickening involves transdifferentiation of embryonic endothelial cells. Anat Rec 258:47-57.
7. Benditt EP, Benditt JM. 1973. Evidence for a monoclonal origin of human atherosclerotic plaques. Proc Natl Acad Sci USA 70:1753-1757.
8. Beranek JT. 2001. Vascular endothelial cell is a stem cell for neointimal formation after injury. J Thorac Cardiovasc Surg 121:820.
9. Bochaton-Piallat ML, Ropraz P, Gabbiani F, Gabbiani G. 1996. Phenotypic heterogeneity of rat arterial smooth muscle cell clones. Arterioscler Thromb Vasc Biol 16:815-820.
10. Boyer AS, Ayerinskas II, Vincent EB, McKinney LA, Weeks DL, Runyan RB. 1999a. TGFβ-2 and TGFβ-3 have separate and sequential activities during epithelial-mesenchymal cell transformation in the embryonic heart. Dev Biol 208:530-545.
11. Boyer AS, Erickson CP, Runyan R. 1999b. Epithelial mesenchymal transformation in the embryonic heart is mediated through distinct pertussis toxin-sensitive and TGFβ signal transduction mechanisms. Dev Dyn 214:81-91.
12. Cavallaro U, Perilli A, Castelli V, Pepper MS, Soria MR. 2001a. FGF-2 promotes disassembly of actin cytoskeleton and shape changes in murine vascular cells. Microvasc Res 61:211-214.
13. Cavallaro U, Tenan M, Castelli V, Perilli A, Maggiano N, Van Meir E, Montesano R, Soria M, Pepper MS. 2001b. Response of bovine endothelial cells to FGF-2 and VEGF is dependent on their site of origin: relevance of the regulation of angiogenesis. J Cell Biochem 82:619-633.
14. Clowes AW, Clowes MM, Reidy MA. 1986. Kinetics of cellular proliferation after arterial injury. Lab Invest 54:295-303.
15. Cucina A, Sterpatti AV, Borrelli V, Pagliei S, Cavallaro A, D'Angelo LS. 1998. Shear stress induces transforming growth factor-beta1 release by arterial endothelial cells. Surgery 128:212-217.
16. Davidson G, Dono R, Zeller R. 2001. FGF signalling is required for differentiation-induced cytoskeletal reorganization and formation of actin-based processes by podocytes. J Cell Sci 114:3359-3366.
17. Dell'Era P, Presta M, Ragnotti G. 1991. Nuclear localization of endogenous basic fibroblast growth factor in cultured endothelial cells. Exp Cell Res 192:505-510.
18. DeRuiter MC, Poelmann RE, VanMunsteren JC, Mironou V, Markwald RR, Gittenberger-de Groot AC. 1997. Embryonic endothelial cells transdifferentiate into mesenchymal cells expressing smooth muscle actins in vivo and in vitro. Circ Res 80:444-451.
19. Ehler E, Jat PS, Noble MD, Citi S, Draeger A. 1995. Vascular smooth muscle cells of H-2Kb-tsA58 transgenic mice. Characterization of cell lines with distinct properties. Circulation 92:3289-3296.
20. Ettenson DS, Gotlieb AI. 1994. Endothelial wounds with disruption in cell migration repair primarily by cell proliferation. Microvasc Res 48:328-337.
21. Frid MG, Aldashev AA, Dempsey EE, Stenmark KR. 1997. Smooth muscle cells isolated from discrete compartments of the mature vascular media exhibit unique phenotypes and distinct growth capabilities. Circ Res 81:940-952.
22. Gittenberger-de Groot AC, DeRuiter MC, Bergwerff M, Poelman RE. 1999. Smooth muscle cell origin and its relation to heterogeneity in development and disease. Arterioscler Thromb Vasc Biol 19:1589-1594.
23. Gordon D, Mohai LG, Schwartz SM. 1986. Induction of polyploidy in cultures of neonatal rat aortic smooth muscle cells. Circ Res 59:633-644.
24. Graterol A, Arciniegas E, De Sanctis JB. 2000. Endothelial cells scraped from the luminal surface of bovine pulmonary artery give rise to nonmuscle cells. Microvasc Res 60:1-7.
25. Hamburger V, Hamilton HL. 1992. A series of normal stages in the development of the chick embryo. Dev Dyn 195:231-272.
26. Heimark RL, Twardzik DR, Schwartz SM. 1986. Inhibition of endothelial regeneration by type-beta transforming growth factor from platelets. Science 233:1078-1080.
27. Herman IM, Brant AM, Warty VS, Bonaccorso J, Klein EC, Kormos RL, Borovetz HS. 1987. Hemodynamics and the vascular endothelial cytoskeleton. J Cell Biol 105:291-302.
28. Holifield B, Helgason T, Jemelca S, Taylor A, Navran S, Allen J, Seidel CL. 1996. Differentiated vascular myocytes: are they involved in neointimal formation? J Clin Invest 97:814-825.
29. Kohler A, Jostarndt-Fögen K, Rottner K, Alliegro M, Draeger A. 1999. Intima-like smooth muscle cells: developmental link between endothelium and media? Anat Embryol 200:313-323.
30. Lampugnani MG, Dejana E. 1997. Interendothelial junctions: structure, signalling and functional roles. Curr Opin Cell Biol 9:674-682.
31. Li S, Fan Y-S, Chow LH, Van Den Diepstraten C, Van der Veer E, Sims SM, Pickering G. 2001. Innate diversity of adult human arterial smooth muscle cells. Circ Res 89:517-527.
32. Lindner V, Reidy MA, Fingerle J. 1989. Regrowth of arterial endothelium. Denudation with minimal trauma leads to complete endothelial regrowth. Lab Invest 61:556-563.
33. Lotz M, Rabinovitz I, Mercurio A. 2000. Intestinal restitution: progression of actin cytoskeleton rearrangements and integrin function in a model of epithelial wound healing. Am J Pathol 156:985-996.
34. Majesky MW, Benditt EP, Schwartz SM. 1988. Expression and developmental control of platelet-derived growth factor A-chain and B-chain/sis genes in rat aortic smooth muscle cells. Proc Natl Acad Sci USA 85:1524-1528.
35. Majesky MW, Giachelli CM, Reidy MA, Schwartz SM. 1992. Rat carotid neointimal smooth muscle cells reexpress a developmentally regulated mRNA phenotype during repair of arterial injury. Circ Res 71:759-768.
36. Malek AM, Gibbons GH, Dzau VJ, Izumo S. 1993. Fluid shear stress differentially modulates expression of genes encoding basic fibroblast growth factor and platelet-derived growth factor B chain in vascular endothelium. J Clin Invest 92:2013-2021.
37. McNeil PL, Muthukrishnan L, Warder E, D'Amore PA. 1989. Growth factors are released by mechanically wounded endothelial cells. J Cell Biol 109:811-822.
38. McNeil PL, Steinhardt RA. 1997. Loss, restoration, and maintenance of plasma membrane integrity. J Cell Biol 137:1-4.
39. Montesano R, Vassalli J, Baird A, Guillemin R, Orci L. 1986. Basic fibroblast growth factor induces angiogenesis in vitro. Proc Natl Acad Sci USA 83:7297-7301.
40. Morabito Ch, Dettman R, Kattan J, Collier M, Bristow J. 2001. Positive and negative regulation of epicardial-mesenchymal tranformation during avian heart development. Dev Biol 234:204-215.
41. Muthukrishnan L, Warder E, McNeil P. 1991. Basic fibroblast growth factor is efficiently released from a cytosolic storage site through plasma membrane disruptions of endothelial cells. J Cell Physiol 148:1-16.
42. Nakajima Y, Mironov V, Yamagishi T, Nakamura H. 1997. Expression of smooth muscle alpha-actin in mesenchymal cells during formation of avian endocardial cushion tissue: a role for transforming growth factor β3. Dev Dyn 209:296-309.
43. Nakajima Y, Yamagishi T, Hokari S, Nakamura H. 2000. Mechanisms involved in valvuloseptal endocardium cushion formation in early cardiogenesis: roles of transforming growth factor (TGF)-β and bone morphognetic protein (BMP). Anat Rec 258:119-127.
44. Ohno M, Cooke JP, Dzau VJ, Gibbons GH. 1995. Fluid shear stress induces endothelial transforming growth factor beta-1 transcription and production. Modulation by potassium channel blockade. J Clin Invest 95:1363-1369.
45. Orlandi A, Ehrlich HP, Ropraz P, Spagnoli LG, Gabbiani G. 1994. Rat aortic smooth muscle isolated from different layers and at different times after endothelial denudation show distinct biological features in vitro. Arterioscler Thromb Vasc Biol 14:982-989.
46. Paranya G, Vineberg S, Dvorin E, Kaushal S, Roth S, Rabkin E, Schoen F, Bischoff J. 2001. Aortic valve endothelial cells undergo transforming growth factor-β-mediated and non-transforming growth factor-β-mediated transdifferentiation in vitro. Am J Pathol 159:1335-1343.
47. Pauletto P, Chiavegato A, Giuriato L, Scatem M, Faggin E, Grisenti A, Sarzani R, Paci MV, Fulgeri PD, Rappelli A, Pessina AC, Sartore S. 1994. Hyperplastic growth of aortic smooth muscle cells in renovascular hypertensive rabbits is characterized by the expansion of an immature cell phenotype. Circ Res 74:774-788.
48. Pepper MS, Belin D, Montesano R, Orci L, Vassalli JD. 1990. Transforming growth factor-beta1 modulates basic fibroblast growth factor-induced proteolytic and angiogenic properties of endothelial cells in vitro. J Cell Biol 111:743-755.
49. Ramsdell AF, Markwald RR. 1997. Induction of endocardial cushion tissue in the avian heart is regulated, in part, by TGFβ3-mediated autocrine signaling. Dev Biol 188:64-74.
50. Reinhart WH. 1994. Shear-dependence of endothelial functions. Experientia 50:87-93.
51. Renko M, Quarto N, Morimoto T, Rifkin DB. 1990. Nuclear and cytoplasmic localization of different basic fibroblast growth factor species. J Cell Physiol 144:108-114.
52. Rhoads DN, Eskin SG, McIntire LV. 2000. Fluid flow releases fibroblast growth factor-2 from human aortic smooth muscle cells. Arterioscler Thromb Vasc Biol 20:416-421.
53. Sato Y, Rifkin DB. 1988. Autocrine activities of basic fibroblast growth factor: regulation of endothelial movement, plasminogen activator synthesis, and DNA synthesis. J Cell Biol 107:1199-1205.
54. Schwartz SM, deBlois D, O'Brien ERM. 1995a. The intima: soil for atherosclerosis and restenosis. Circ Res 77:445-465.
55. Schwartz SM, Majesky MW, Murry CE. 1995b. The intima: development and monoclonal responses to injury. Atherosclerosis 118: S125-S140.
56. Seidel CL. 1997. Cellular heterogeneity of the vascular tunica media: implications for vessel wall repair. Arterioscler Thromb Vasc Biol 17:1868-1871.
57. Shanahan CM, Weisberg PL. 1998. Smooth muscle heterogeneity. Pattern of gene expression in vascular smooth muscle cells in vitro and in vivo. Arterioscler Thromb Vasc Biol 18:333-338.
58. Taylor CR, Cote RJ. 1994. Immunomicroscopy: a diagnostic tool for the surgical pathologist. Philadelphia: WB Sanders. p 21-41.
59. Topouzis S, Majesky MW. 1996. Smooth muscle lineage diversity in the chick embryo. Two types of aortic smooth muscle cell differ in growth and receptor-mediated transcriptional responses to transforming growth factor-β. Dev Biol 178:430-445.
60. Topper NJ, Gimbrone MA. 1999. Blood flow and vascular gene expression: fluid shear stress as a modulator of endothelial phenotype. Mol Med Today 5:40-46.
61. Tsuboi R, Sato Y, Rifkin DB. 1990. Correlation of cell migration, cell invasion, receptor number, proteinase production and basic fibroblast growth factor levels in endothelial cells. J Cell Biol 110:511-517.
62. Tuder RM, Groves B, Badesch DB, Voelkel NF. 1994. Exuberant endothelial cell growth and elements of inflammation are present in plexiform lesions of pulmonary hypertension. Am J Pathol 144:275-285.
63. Villaschi S, Nicosia RF. 1993. Angiogenic role of endogenous basic fibroblast growth factor released by rat aorta after injury. Am J Pathol 143:181-190.
64. Villaschi S, Nicosia RF, Smith MR. 1994. Isolation of a morphologically and functionally distinct smooth muscle cell type from the intimal aspect of the normal rat aorta: evidence for smooth muscle cell heterogeneity. In Vitro Cell Dev Biol Anim 30A:589-595.
65. Walker LN, Bowen-Pope DF, Ross R, Reidy MA. 1986. Production of platelet-derived growth factor-like molecules by cultured arterial smooth muscle cells accompanies proliferation after arterial injury. Proc Natl Acad Sci USA 83:7311-7315.
66. Wong MK, Gotlieb AI. 1984. In vitro reendothelialization of a single-cell wound. Lab Invest 51:75-81.
67. Wong MK, Gotlieb AI. 1988. The reorganization of microfilaments, centrosomes, and microtubules during in vitro small wound reendothelialization. J Cell Biol 107:1777-1783.
68. Yang Y, Relan NK, Przywara DA, Schuger L. 1999. Embryonic mesenchymal cells share the potential for smooth muscle differentiation: myogenesis is controlled by the cell's shape. Development 126:3027-3033.
69. Yu Z-X, Biro S, Fu Y, Sánchez J, Smale G, Sasse J, Ferrans V, Casscells W. 1993. Localization of basic fibroblast growth factor in bovine endothelial cells: immunohistochemical and biochemical studies. Exp Cell Res 204:247-259.