Zinc treatment prevents lipopolysaccharide-induced teratogenicity in mice

Birth Defects Research Part A - Clinical and Molecular Teratology

Volumn 67, Issue 4, 2003, Pages 240-245

  Carey, Luke C ^a,b   Berbée, Paulien L ^a   Coyle, Peter ^a   Philcox, Jeffrey C ^a   Rofe, Allan M ^a  

^a INSTITUTE OF MEDICAL AND VETERINARY SCIENCE   (Australia)

^b UNIVERSITY OF ADELAIDE   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

ALCOHOL; BINDING PROTEIN; LIPOPOLYSACCHARIDE; METALLOTHIONEIN; ZINC; ZINC SULFATE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; ENVIRONMENTAL EXPOSURE; FEMALE; GESTATIONAL AGE; HOMEOSTASIS; MALE; MOUSE; NONHUMAN; PREGNANCY; PRIORITY JOURNAL; TERATOGENICITY; ZINC BLOOD LEVEL;

ABNORMALITIES, DRUG-INDUCED; ANIMALS; ESCHERICHIA COLI; FEMALE; LIPOPOLYSACCHARIDES; LIVER; MALE; METALLOTHIONEIN; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; PREGNANCY; ZINC;

EID: 0141960457     PISSN: 15420752     EISSN: None     Source Type: Journal    
DOI: 10.1002/bdra.10035     Document Type: Article

References (28)

1. Abe S, Matsumi M, Tsukioki M, et al. 1987. Metallothionein and zinc metabolism in endotoxin shock rats. Experientia Suppl 52:587-594.
2. Aschkenasy A. 1978. Effects of a protein deprived diet on the hepatotoxicity, and the DNA synthetic, mitogenic, and immunological actions of microbial lipopolysaccharides in the rat. J Nutr 108:1527-1539.
3. Athanassakis I, Aifantis I, Ranella A, et al. 1999. Inhibition of nitric oxide production rescues LPS-induced fetal abortion in mice. Nitric Oxide 3:216-224.
4. Carey LC, Coyle P, Philcox JC, Rofe AM. 2000a. Maternal ethanol exposure is associated with decreased plasma zinc and increased fetal abnormalities in normal but not metallothionein-null mice. Alcohol Clin Exp Res 24:213-219.
5. Carey LC, Coyle P, Philcox JC, Rofe AM. 2000b. Ethanol decreases zinc transfer to the fetus in normal but not metallothionein-null mice. Alcohol Clin Exp Res 24:1236-1240.
6. Coid CR. 1976. Bacterial endotoxin and impaired fetal development. Experientia 32:735-736.
7. Collins JG, Smith MA, Arnold RR, Offenbacher S. 1994. Effects of Escherichia coli and Porphyromonas gingivalis lipopolysaccharide on pregnancy outcome in the golden hamster. Infect Immun 62:4652-4655.
8. Daston GP, Overmann GJ, Taubeneck MW, et al. 1991. The role of metallothionein induction and altered zinc status in maternally mediated developmental toxicity: comparison of the effects of urethane and styrene. Toxicol Appl Pharmacol 110:450-463.
9. Daston GP, Overmarm GJ, Baines D, et al. 1994. Altered Zn status by α-hederin in the pregnant rat and its relationship to adverse developmental outcome. Reprod Toxicol 1994 8:15-24.
10. De SK, McMaster MT, Andrews GK. 1990. Endotoxin induction of murine metallothionein gene expression. J Biol Chem 265:15267-15274.
11. Dreosti IE, Buckley RA, Chem HCA, Record IR. 1986. The teratogenic effect of zinc deficiency and accompanying feeding patterns in mice. Proc Soc Exp Biol Med 128:168-174.
12. Eaton DL, Toal BF. 1982. Evaluation of the Cd/hemoglobin assay for the rapid determination of metallothionein in biological tissues. Toxicol Appl Pharmacol 66: 134-142.
13. Guise JM, Mahon SM, Aickin M, et al. 2001. Screening for bacterial vaginosis in pregnancy. Am J Prev Med 20(Suppl):62-72.
14. Hewett JA, Roth RA. 1995. The coagulation system, but not circulating fibrinogen, contributes to liver injury in rats exposed to lipopolysaccharide from gram-negative bacteria. J Pharmacol Exp Ther 272:53-62.
15. Hickory W, Nanda R, Catalanotto FA. 1979. Fetal skeletal malformations associated with moderate zinc deficiency during pregnancy. J Nutr 109:883-891.
16. Keen CL, Hurley LS. 1989. Zinc and reproduction: effects of deficiency on fetal and postnatal development. In: Mills CF, editor. Zinc and human biology. London: Springer-Verlag. pp. 183-200.
17. Lanning JC, Hilbelink DR, Chen LT. 1983. Teratogenic effects of endotoxin on the golden hamster. Teratogen Carcinogen Mutagen 3:145-149.
18. Michalska AE, Choo KH. 1993. Targeting and germ-line transmission of a null mutation at the metallothionein I and II loci in mouse. Proc Natl Acad Sci USA 90:8088-8092.
19. Ornoy A, Altshuler S. 1976. Maternal endotoxemia, fetal anomalies, and central nervous system damage: a rat model of a human problem. Am J Obstet Gynecol 124:196-207.
20. Philcox JC, Coyle P, Michalska A, et al. 1995. Endotoxin-induced inflammation does not cause hepatic zinc accumulation in mice lacking metallothionein gene expression. Biochem J 308:543-546.
21. Platz-Christensen JJ, Brandberg A, Wiqvist N. 1992. Increased prostaglandin concentrations in the cervical mucus of pregnant women with bacterial vaginosis. Prostaglandins 43:133-134.
22. Platz-Christensen JJ, Mattsby-Baltzer I, Thomsen P, Wiqvist N. 1993. Endotoxin and irtterleukin-1 α in the cervical mucus and vaginal fluid of pregnant women with bacterial vaginosis. Am J Obstet Gynecol 169: 1161-1166.
23. Rofe AM, Philcox JC, Coyle P. 1996. Trace metal, acute phase and metabolic response to endotoxin in metallothionein-null mice. Biochem J 314:793-797.
24. Sauerbier, I. 1987. Circadian modification of ethanol damage in utero to mice. Am J Anat 178:170-174.
25. Silver RM, Edwin SS, Trautman MS, et al. 1995. Bacterial lipopolysaccharide-mediated fetal death. Production of a newly recognized form of inducible cyclooxygenase (COX-2) in murine decidua in response to lipopolysaccharide. J Clin Invest 95:725-731.
26. Sliver RM, Lohner WS, Daynes RA, et al. 1994. Lipopolysaccharide-induced fetal death: the role of tumor necrosis factor alpha. Biol Reprod 50: 1108-1112.
27. Taubeneck MW, Daston GP, Rogers JM, Keen CL. 1994. Altered maternal zinc metabolism following exposure to diverse developmental toxicants. Reprod Toxicol 8:25-40.
28. Taubeneck MW, Daston GP, Rogers JM, et al. 1995. Tumor necrosis factor-α alters maternal and embryonic zinc metabolism and is developmentally toxic in mice. J Nutr 125:908-919.