The mouse matrix metalloproteinase, epilysin (MMP-28), is alternatively spliced and processed by a furin-like proprotein convertase

Biochemical Journal

Volumn 375, Issue 1, 2003, Pages 191-197

  Illman, Sara A ^a   Keski Oja, Jorma ^a   Parks, William C ^b   Lohi, Jouko ^a  

^a UNIVERSITY OF HELSINKI   (Finland)

^b WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Alternative splicing; Extracellular matrix; Matrix metalloproteinase; Proteolysis; Tissue expression

Indexed keywords

AMINO ACIDS; BIOLOGICAL ORGANS; CLONING; DNA; PHYSIOLOGY; RNA; TISSUE;

LUNGS;

ENZYMES;

COMPLEMENTARY DNA; EPILYSIN; FURIN; FURIN LIKE PROPROTEIN CONVERTASE; HEMOPEXIN; MATRIX METALLOPROTEINASE; MESSENGER RNA; PROTEIN; PROTEIN INHIBITOR; UNCLASSIFIED DRUG; MMP28 PROTEIN, MOUSE; RECOMBINANT PROTEIN; SERINE PROTEINASE; SUBTILISIN;

ALTERNATIVE RNA SPLICING; AMINO ACID SEQUENCE; ANIMAL CELL; ARTICLE; CANCER CELL; CONTROLLED STUDY; DNA DETERMINATION; EXON; FIBROSARCOMA; GASTROINTESTINAL TRACT; GENE EXPRESSION; GENE LOCATION; GENETIC CODE; HEART; HUMAN; HUMAN CELL; IN VIVO STUDY; LUNG; MOLECULAR CLONING; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PLACENTA; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN DEGRADATION; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PROCESSING; PROTEIN SECRETION; SEQUENCE ANALYSIS; TESTIS; TISSUE; UTERUS; ANIMAL; CELL CULTURE; CELL LINE; CHO CELL; GENETICS; HAMSTER; METABOLISM; MOLECULAR GENETICS; SEQUENCE ALIGNMENT; TISSUE DISTRIBUTION;

ANIMALIA;

ALTERNATIVE SPLICING; AMINO ACID SEQUENCE; ANIMALS; CELL LINE, TRANSFORMED; CHO CELLS; CLONING, MOLECULAR; CRICETINAE; FURIN; HUMANS; MATRIX METALLOPROTEINASES; MATRIX METALLOPROTEINASES, SECRETED; MICE; MOLECULAR SEQUENCE DATA; PROPROTEIN CONVERTASES; RECOMBINANT PROTEINS; SEQUENCE ALIGNMENT; SUBTILISINS; TISSUE DISTRIBUTION; TUMOR CELLS, CULTURED;

EID: 0141953676     PISSN: 02646021     EISSN: None     Source Type: Journal    
DOI: 10.1042/BJ20030497     Document Type: Article

References (25)

1. Sternlicht, M. D. and Werb, Z. (2001) How matrix metalloproteinases regulate cell behavior. Annu. Rev. Cell Dev. Biol. 17, 463-516
2. Wilson, C. L., Ouellette, A. J., Satchell, D. P., Ayabe, T., Lopez-Boado, Y. S., Stratman, J. L., Hultgren, S. J., Matrisian, L. M. and Parks, W. C. (1999) Regulation of intestinal α-defensin activation by the metalloproteinase matrilysin in innate host defense. Science 286, 113-117
3. Liu, Z., Zhou, X., Shapiro, S. D., Shipley, J. M., Twining, S. S., Diaz, L. A., Senior, R. M. and Werb, Z. (2000) The serpin α1-proteinase inhibitor is a critical substrate for gelatinase B/MMP-9 in vivo. Cell (Cambridge, Mass.) 102, 647-655
4. Taipale, J. and Keski-Oja, J. (1997) Growth factors in the extracellular matrix. FASEB J. 11, 51-59
5. Afzal, S., Lalani, E. N., Poulsom, R., Stubbs, A., Rowlinson, G., Sato, H., Seiki, M. and Stamp, G. W. (1998) MT1-MMP and MMP-2 mRNA expression in human ovarian tumors: possible implications for the role of desmoplastic fibroblasts. Hum. Pathol. 29, 155-165
6. Ravanti, L. and Kähäri, V. M. (2000) Matrix metalloproteinases in wound repair (review). Int. J. Mol. Med. 6, 391-407
7. Pei, D. and Weiss, S. J. (1995) Furin-dependent intracellular activation of the human stromelysin-3 zymogen. Nature (London) 375, 244-247
8. Pei, D. and Weiss, S. J. (1996) Transmembrane-deletion mutants of the membrane-type matrix metalloproteinase-1 process progelatinase A and express intrinsic matrix-degrading activity. J. Biol. Chem. 271, 9135-9140
9. Sato, H., Kinoshita, T., Takino, T., Nakayama, K. and Seiki, M. (1996) Activation of a recombinant membrane type 1-matrix metalloproteinase (MT1-MMP) by furin and its interaction with tissue inhibitor of metalloproteinases (TIMP)-2. FEBS Lett. 393, 101-104
10. Kang, T., Nagase, H. and Pei, D. (2002) Activation of membrane-type matrix metalloproteinase 3 zymogen by the proprotein convertase furin in the trans-Golgi network. Cancer Res. 62, 675-681
11. Lohi, J., Wilson, C. L., Roby, J. D. and Parks, W. C. (2001) Epilysin, a novel human matrix metalloproteinase (MMP-28) expressed in testis and keratinocytes and in response to injury. J. Biol. Chem. 276, 10134-10144
12. Saarialho-Kere, U., Kerkelä, E., Jahkola, T., Suomela, S., Keski-Oja, J. and Lohi, J. (2002) Epilysin (MMP-28) expression is associated with cell proliferation during epithelial repair. J. Invest. Dermatol. 119, 14-21
13. Li, Q. L., Illman, S. A., Wang, H. M., Liu, D. L., Lohi, J. and Zhu, C. (2003) Matrix metalloproteinase-28 transcript and protein are expressed in Rhesus monkey placenta during early pregnancy. Mol. Hum. Reprod. 9, 205-211
14. Marchenko, G. N. and Strongin, A. Y. (2001) MMP-28, a new human matrix metalloproteinase with an unusual cysteine-switch sequence is widely expressed in tumors. Gene 265, 87-93
15. Boukamp, P., Petrussevska, R. T., Breitkreutz, D., Hornung, J., Markham, A. and Fusenig, N. E. (1988) Normal keratinization in a spontaneously immortalized aneuploid human keratinocyte cell line. J. Cell Biol. 106, 761-771
16. Hofmann, M. C., Narisawa, S., Hess, R. A. and Millan, J. L. (1992) Immortalization of germ cells and somatic testicular cells using the SV40 large T antigen. Exp. Cell Res. 201, 417-435
17. Hobbs, S., Jitrapakdee, S. and Wallace, J. C. (1998) Development of a bicistronic vector driven by the human polypeptide chain elongation factor 1α promoter for creation of stable mammalian cell lines that express very high levels of recombinant proteins. Biochem. Biophys. Res. Commun. 252, 368-372
18. Lehti, K., Lohi, J., Valtanen, H. and Keski-Oja, J. (1998) Proteolytic processing of membrane-type-1 matrix metalloproteinase is associated with gelatinase A activation at the cell surface. Biochem. J. 334, 345-353
19. Illman, S. A., Keski-Oja, J. and Lohi, J. (2001) Promoter characterization of the human and mouse epilysin (MMP-28) genes. Gene 275, 185-194
20. Cao, J., Drews, M., Lee, H. M., Conner, C., Bahou, W. F. and Zucker, S. (1998) The propeptide domain of membrane type 1 matrix metalloproteinase is required for binding of tissue inhibitor of metalloproteinases and for activation of pro-gelatinase A. J. Biol. Chem. 273, 34745-34752
21. Pendas, A. M., Knauper, V., Puente, X. S., Llano, E., Mattei, M. G., Apte, S., Murphy, G. and Lopez-Otin, C. (1997) Identification and characterization of a novel human matrix metalloproteinase with unique structural characteristics, chromosomal location, and tissue distribution. J. Biol. Chem. 272, 4281-4286
22. Maquoi, E., Noel, A., Frankenne, F., Angliker, H., Murphy, G. and Foidart, J. M. (1998) Inhibition of matrix metalloproteinase 2 maturation and HT1080 invasiveness by a synthetic furin inhibitor. FEBS Lett. 424, 262-266
23. Matsumoto, S., Katoh, M., Saito, S., Watanabe, T. and Masuho, Y. (1997) Identification of soluble type of membrane-type matrix metalloproteinase-3 formed by alternatively spliced mRNA. Biochim. Biophys. Acta 1354, 159-170
24. Hu, S. I., Klein, M., Carozza, M., Rediske, J., Peppard, J. and Qi, J. S. (1999) Identification of a splice variant of neutrophil collagenase (MMP-8). FEBS Lett. 443, 8-10
25. Luo, D., Mari, B., Stoll, I. and Anglard, P. (2002) Alternative splicing and promoter usage generates an intracellular stromelysin 3 isoform directly translated as an active matrix metalloproteinase. J. Biol. Chem. 277, 25527-25536