Cholestatic jaundice caused by sequential carbimazole and propylthiouracil treatment for thyrotoxicosis

Hong Kong Medical Journal

Volumn 9, Issue 5, 2003, Pages 377-380

  Chan, A O O ^a   Ng, I O L ^b   Lam, C M ^b   Shek, T W H ^b   Lai, C L ^a  

^a UNIVERSITY OF HONG KONG   (Hong Kong)

^b NONE

Author keywords

Antithyroid agents; Carbimazole; Cholestasis; Propylthiouracil

Indexed keywords

ALBUMIN; ALPHA 1 ANTITRYPSIN; ALPHA FETOPROTEIN; ANTIBIOTIC AGENT; CARBIMAZOLE; CARCINOEMBRYONIC ANTIGEN; COMPLEMENT COMPONENT C3; FIBRINOGEN; GLYCOGEN; IMMUNOGLOBULIN; IMMUNOGLOBULIN A; IMMUNOGLOBULIN G; IMMUNOGLOBULIN M; PROPYLTHIOURACIL;

ADULT; ARTICLE; CASE REPORT; CELL INCLUSION; CROSS REACTION; CYTOPLASM; ECHOCARDIOGRAPHY; ELECTRON MICROSCOPY; HISTOLOGY; HOSPITAL ADMISSION; HUMAN; IMMUNOHISTOCHEMISTRY; LIVER BIOPSY; LIVER CELL; LIVER FAILURE; LUNG BIOPSY; MALE; OBSTRUCTIVE JAUNDICE; PNEUMONIA; RASH; THYROTOXICOSIS; URTICARIA;

ADULT; ANTITHYROID AGENTS; CARBIMAZOLE; DRUG ADMINISTRATION SCHEDULE; FATAL OUTCOME; HUMANS; JAUNDICE, OBSTRUCTIVE; LIVER FAILURE, ACUTE; MALE; PROPYLTHIOURACIL; THYROTOXICOSIS;

EID: 0141927879     PISSN: 10242708     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (16)

1. Hanson JS. Propylthiouracil and hepatitis. Two cases and a review of the literature. Arch Intern Med 1984;144:994-6.
2. Liaw YF, Huang MJ, Fan KD, Li KL, Wu SS, Chen TJ. Hepatic injury during propylthiouracil therapy in patients with hyperthyroidism. A cohort study. Ann Intern Med 1993;118:424-8.
3. Ayensa C, Diaz de Otazu R, Cia JM. Carbimazole-induced cholestatic hepatitis. Arch Intern Med 1986;146:1455.
4. Blom H, Stolk J, Schreuder HB, von Blomberg-van der Flier M. A case of carbimazole-induced intrahepatic cholestasis. An immune-mediated reaction? Arch Intern Med 1985;145:1513-5.
5. Dinsmore WW, O'Hara MD, Callender ME. Postanaesthetic carbimazole jaundice. N Engl J Med 1983;309:438.
6. Ozenne G, Manchon ND, Doucet J, Hemet J, Schrub JC, Bercoff E. Carbimazole-induced acute cholestatic hepatitis. J Clin Gastroenterol 1989;11:95-7.
7. Sadoul JL, Canivet B, Freychet P. Toxic hepatitis induced by antithyroid drugs: four cases including one with cross-reactivity between carbimazole and benzylthiouracil. Eur J Med 1993;2:473-7.
8. Seidman DS, Livni E, Ilie B, Blum I. Propylthiouracil-induced cholestatic jaundice. J Toxicol Clin Toxicol 1986;24:353-60.
9. Lock DR, Sthoeger ZM. Severe hepatotoxicity on beginning propylthiouracil therapy. J Clin Gastroenterol 1997;24:267-9.
10. Jackson IM. Management of thyrotoxicosis. J Maine Med Assoc 1975;66:224-32,243.
11. Levy M. Propylthiouracil hepatotoxicity. A review and case presentation. Clin Pediatr (Phila) 1993;32:25-9.
12. Ichiki Y, Akahoshi M, Yamashita N, et al. Propylthiouracil-induced severe hepatitis: a case report and review of the literature. J Gastroenterol 1998;33:747-50.
13. Weiss M, Hassin D, Bank H. Propylthiouracil-induced hepatic damage. Arch Intern Med 1980;140:1184-5.
14. Mihas AA, Holley P, Koff RS, Hirschowitz BI. Fulminant hepatitis and lymphocyte sensitization due to propylthiouracil. Gastroenterology 1976;70:770-4.
15. Pacini F, Sridama V, Refetoff S. Multiple complications of propylthiouracil treatment: granulocytopenia, eosinophilia, skin reaction and hepatitis with lymphocyte sensitization. J Endocrinol Invest 1982;5:403-7.
16. Phillips MJ, Poucell S, Patterson J, Valencia P. Drug and toxic effects. In: The liver. An atlas and text of ultrastructural pathology. New York: Raven Press; 1987:159-72.