Severe hepatotoxicity on beginning propylthiouracil therapy

Journal of Clinical Gastroenterology

Volumn 24, Issue 4, 1997, Pages 267-269

  Lock, Dennis R ^a   Sthoeger, Zev M ^a  

^a KAPLAN HOSPITAL   (Israel)

Author keywords

Drug induced hepatotoxicity; Propylthiouracil; Reversible prolonged PTU induced hepatotoxicity

Indexed keywords

PROPYLTHIOURACIL;

ABDOMINAL PAIN; ADULT; ARTICLE; CASE REPORT; CHOLESTATIC HEPATITIS; DIARRHEA; FEMALE; GRAVES DISEASE; HUMAN; LIVER BIOPSY; LIVER FUNCTION TEST; LIVER TOXICITY; NAUSEA; PERCUTANEOUS BIOPSY; PRIORITY JOURNAL; PRURITUS;

ANTITHYROID AGENTS; BIOPSY; ENZYME TESTS; FEMALE; GRAVES DISEASE; HEPATITIS, TOXIC; HUMANS; LIVER; LIVER FUNCTION TESTS; MIDDLE AGED; PROPYLTHIOURACIL; TIME FACTORS;

EID: 0030855842     PISSN: 01920790     EISSN: None     Source Type: Journal    
DOI: 10.1097/00004836-199706000-00020     Document Type: Article

References (12)

1. Jonas MM, Eidson MS. Propylthiouracil hepatotoxicity: two pediatric cases and review of the literature. J Pediatr Gastroenterol Nutr 1988;7:776-9.
2. Peter SA. Propylthiouracil-associated hepatitis. J Nat Med Assoc 1991;83:75-7.
3. Westphal SA. Hepatotoxicity from propylthiouracil. South Med J 1994;87:943-7.
4. Parker LN. Hepatitis and propylthiouracil. Ann Intern Med 1975; 82:228-9.
5. Liaw YF, Huang MJ, Fan KD, et al. Hepatic injury during propylthiouracil therapy in patients with hyperthyroidism: a cohort study. Ann Intern Med 1993;118:424-8.
6. Fedotin MS, Lefer LG. Liver disease caused by propylthiouracil. Arch Intern Med 1975;135:319-21.
7. Weiss M, Hassin D, Bank H. Propylthiouracil induced hepatic damage. Arch Intern Med 1980;140:1184-5.
8. Eisen MJ. Fulminant hepatitis during treatment with propylthiouracil. N Engl J Med 1953;249:814-6.
9. Huang MJ, Li KL, Wei JS, et al. Sequential liver and bone biochemical changes in hyperthyroidism: prospective controlled follow-up study. Am J Gastroenterol 1994;87:1071-6.
10. Mihas AA, Holley P, Koff RS, et al. Fulminant hepatitis and lymphocyte sensitization due to propylthiouracil. Gastroenterology 1976:70:77-4.
11. Limaye A, Ruffolo PR. Propylthiouracil induced fatal hepatic necrosis. Am J Gastroenterol 1987;82:152-4.
12. Parker WA. Propylthiouracil induced hepatotoxicity. Clin Pharmacol 1982;1:471-1.