Aerosolized granulocyte macrophage colony-stimulating factor (GM-CSF) therapy in metastatic cancer

American Journal of Clinical Oncology: Cancer Clinical Trials

Volumn 26, Issue 5, 2003, Pages 493-498

  Rao, Ravi D ^a   Anderson, Peter M ^a   Arndt, Carola A S ^a   Wettstein, Peter J ^a   Markovic, Svetomir N ^a  

^a MAYO CLINIC   (United States)

Author keywords

Aerosol therapy; Melanoma; Pulmonary metastasis; Renal cell carcinoma; Sarcoma; Sargramostim

Indexed keywords

ANTINEOPLASTIC AGENT; RECOMBINANT GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR;

ADENOID CYSTIC CARCINOMA; ADOLESCENT; ADULT; AEROSOL; AGED; ARTICLE; BACKACHE; CANCER RADIOTHERAPY; CANCER REGRESSION; CLINICAL ARTICLE; CLINICAL TRIAL; COUGHING; CYTOTOXIC T LYMPHOCYTE; DRUG EFFICACY; DRUG TOLERABILITY; DYSPNEA; FEMALE; HEMANGIOPERICYTOMA; HUMAN; KIDNEY CARCINOMA; LUNG METASTASIS; MALE; MELANOMA; PATIENT COMPLIANCE; PHASE 1 CLINICAL TRIAL; PROSTATE CANCER; SARCOMA; SCHOOL CHILD; SEZARY SYNDROME; THROAT DISEASE;

ADMINISTRATION, INHALATION; ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; BIOLOGICAL THERAPY; CHILD; FEMALE; GRANULOCYTE-MACROPHAGE COLONY-STIMULATING FACTOR; HUMANS; LUNG NEOPLASMS; MALE; MIDDLE AGED;

EID: 0141926517     PISSN: 02773732     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.coc.0000037664.04141.D0     Document Type: Article

References (17)

1. Anderson PM, Markovic SN, Sloan JA, et al. Aerosol granulocyte macrophage-colony stimulating factor: a low toxicity, lung-specific biological therapy in patients with lung metastases. Clin Cancer Res 1999;59:2316-23.
2. Lee PP, Yee C, Savage PA, et al. Characterization of circulating T cells specific for tumor-associated antigens in melanoma patients. Nat Med 1999;56:677-85.
3. Wong GG, Witek JS, Temple PA, et al. Human GM-CSF: molecular cloning of the complementary DNA and purification of the natural and recombinant proteins. Science 1985;2284701:810-5.
4. Cantrell MA, Anderson D, Cerretti DP, et al. Cloning, sequence, and expression of a human granulocyte/macrophage colony-stimulating factor. Proc Natl Acad Sci U S A 1985;8218:6250-4.
5. Burgess AW, Begley CG, Johnson GR, et al. Purification and properties of bacterially synthesized human granulocyte-macrophage colony stimulating factor. Blood 1987;691:43-51.
6. Armitage JO. Emerging applications of recombinant human granulocyte-macrophage colony-stimulating factor. Blood 1998;9212:4491-508.
7. Dranoff G, Jaffee E, Lazenby A, et al. Vaccination with irradiated tumor cells engineered to secrete murine granulocyte-macrophage colony-stimulating factor stimulates potent, specific, and long-lasting anti-tumor immunity. Proc Natl Acad Sci U S A 1993;908:3539-43.
8. Disis ML, Bernhard H, Shiota FM, et al. Granulocyte-macrophage colony-stimulating factor: an effective adjuvant for protein and peptide-based vaccines. Blood 1996;881:202-10.
9. Wing EJ, Magee DM, Whiteside TL, et al. Recombinant human granulocyte/macrophage colony-stimulating factor enhances monocyte cytotoxicity and secretion of tumor necrosis factor alpha and interferon in cancer patients. Blood 1989;733:643-6.
10. Dong Z, Kumar R, Yang X, et al. Macrophage-derived metalloelastase is responsible for the generation of angiostatin in Lewis lung carcinoma. Cell 1997;886:801-10.
11. Masucci G, Wersall P, Ragnhammar P, et al. Granulocyte-monocyte-colony-stimulating factor augments the cytotoxic capacity of lymphocytes and monocytes in antibody-dependent cellular cytotoxicity. Cancer Immunol Immunother 1989;294:288-92.
12. Baxevanis CN, Dedoussis GV, Papadopoulos NG, et al. Enhanced human lymphokine-activated killer cell function after brief exposure to granulocyte-macrophage-colony stimulating factor. Cancer 1995;767:1253-60.
13. Kumar R, Yoneda J, Fidler IJ, et al. GM-CSF-transduced B16 melanoma cells are highly susceptible to lysis by normal murine macrophages and poorly tumorigenic in immune-compromised mice. J Leukoc Biol 1999;651:102-8.
14. Chachoua A, Oratz R, Hoogmoed R, et al. Monocyte activation following systemic administration of granulocyte-macrophage colony-stimulating factor. J Immunother Emphasis Tumor Immunol 1994;153:217-24.
15. Spitler LE, Grossbard ML, Ernstoff MS, et al. Adjuvant therapy of stage III and IV malignant melanoma using granulocyte-macrophage colony-stimulating factor. J Clin Oncol 2000;188:1614-21.
16. Reed JA, Ikegami M, Cianciolo ER, et al. Aerosolized GM-CSF ameliorates pulmonary alveolar proteinosis in GM-CSF-deficient mice. Am J Physiol 1999;2764:L556-63.
17. Rose RM, Kobzik L, Dushay K, et al. The effect of aerosolized recombinant human granulocyte macrophage colony-stimulating factor on lung leukocytes in nonhuman primates. Am Rev Respir Dis 1992;1465:1279-86.