Lower concentrations of carotenoids in the critically-ill patient are related to a systemic inflammatory response and increased lipid peroxidation

Clinical Nutrition

Volumn 22, Issue 5, 2003, Pages 459-462

  Quasim, T ^a   McMillan, D C ^a   Talwar, D ^b   Sattar, N ^b   O'Reilly, D St J ^b   Kinsella, J ^a  

^a GLASGOW ROYAL INFIRMARY   (United Kingdom)

^b NHS Greater Glasgow and Clyde Clinical Biochemistry Service   (United Kingdom)

Author keywords

C reactive protein; Carotenoids; Critical care; Malonydialdehyde; Systemic inflammatory response; tocopherol

Indexed keywords

ALPHA CAROTENE; ALPHA TOCOPHEROL; ANTIOXIDANT; BETA CAROTENE; C REACTIVE PROTEIN; CAROTENOID; CHOLESTEROL; LYCOPENE; MALONALDEHYDE; TRIACYLGLYCEROL; VITAMIN; XANTHOPHYLL;

ADULT; AGED; ARTICLE; ASSISTED VENTILATION; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; CORRELATION ANALYSIS; CRITICAL ILLNESS; FEMALE; HUMAN; INFLAMMATION; LIPID PEROXIDATION; MAJOR CLINICAL STUDY; MALE; RESPIRATORY FAILURE; SYSTEMIC INFLAMMATORY RESPONSE SYNDROME; VITAMIN BLOOD LEVEL;

EID: 0141925899     PISSN: 02615614     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0261-5614(03)00044-X     Document Type: Article

References (20)

1. Fuhrman M P. Antioxidant supplementation in critical illness: what do we know? Nutrition 2000; 16: 470-471
2. Oldham K M, Bowen P E. Oxidative stress in critical care: is antioxidant supplementation beneficial? J Am Diet Assoc 1998; 98: 1001-1008
3. Galloway P, McMillan D C, Sattar N. Effect of the inflammatory response on trace element and vitamin status. Ann Clin Biochem 2000; 37: 289-297
4. Kritchevsky S B, Bush A J, Pahor M, Gross M D. Serum carotenoids and markers of inflammation in nonsmokers. Am J Epidemiol 2000; 152: 1065-1071
5. Curran F J, Sattar N, Talwar D, Baxter J N, Imrie C W. Relationship of carotenoid and vitamins A and E with the acute inflammatory response in acute pancreatitis. Br J Surg 2000; 87: 301-305.
6. Talwar D, Ha T K, Scott H R et al. Effect of inflammation on measures of antioxidant status in patients with non-small cell lung cancer. Am J Clin Nutr 1997; 66: 1283-1285.
7. McMillan D C, Sattar N, Talwar D, O'Reilly D S, McArdle C S. Changes in micronutrient concentrations following anti-inflammatory treatment in patients with gastrointestinal cancer. Nutrition 2000; 16: 425-428
8. Schweigert F J. Inflammation-induced changes in the nutritional biomarker serum retinol and carotenoids. Curr Opin Clin Nutr Metab Care 2001; 4: 477-481
9. Mayers I, Johnson D. The nonspecific inflammatory response to injury. Can J Anaesth 1998; 45: 871-879
10. Moore K, Roberts L J. Measurement of lipid peroxidation. Free Radic Res 1998; 28: 659-671
11. Wiseman H, Halliwell B. Damage to DNA by reactive oxygen and nitrogen species: role in inflammatory disease and progression to cancer. Biochem J 1996; 313: 17-29
12. Miller N J, Sampson J, Candeias L P, Bramley P M, Rice-Evans C A. Antioxidant activities of carotenes and xanthophylls. FEBS Lett 1996; 384: 240-242
13. Bast A, Haenen G R, van den Berg R, van den Berg H. Antioxidant effects of carotenoids. Int J Vitam Nutr Res 1998; 68: 399-403
14. Tribble D L, Yee A W T, Jones D P. The pathophysiological significance of lipid peroxidation in oxidative cell injury. Hepatology 1976; 7: 377-387
15. Bone R C, Balk R A, Cerra F B et al. Definitions for sepsis, organ failure and guidelines for the use of innovative therapies in sepsis. The ACCP/SCCM Consensus Conference Committee. American College of Chest Physicians/Society of Critical Care Medicine. Chest 1992; 101: 1644-1655
16. Talwar D, Ha T K, Cooney J, Brownlee C, O'Reilly D S. A routine method for the simultaneous measurement of retinol, alpha-tocopherol and five carotenoids in human plasma by reverse phase HPLC. Clin Chim Acta 1998; 23; 270: 85-100
17. Young I S, Trimble E R. Measurement of malondialdehyde in plasma by HPLC with fluorimetric detection. Ann Clin Biochem 1991; 28: 504-508
18. Thurnham D I, Davies J A, Crump B J, Situnayake R D, Davis M. The use of different lipids to express serum tocopherol: lipid ratios for the measurement of vitamin E status. Ann Clin Biochem 1986; 23: 514-520
19. Niki E, Noguchi N, Tsuchihashi H, Gotoh N. Interaction among vitamin C, vitamin E, and beta-carotene. Am J Clin Nutr 1995; 62: 1322S-1326S
20. Bohm F, Edge R, McGarvey D J, Truscott T G. Beta-carotene with vitamins E and C offers synergistic cell protection against NOx. FEBS Lett. 1998; 436: 387-389