-
3
-
-
0033372529
-
Combination antiretroviral therapy and recent declines in AIDS incidence and mortality
-
Vittinghoff E, Scheer S, O'Malley P, et al. Combination antiretroviral therapy and recent declines in AIDS incidence and mortality. J Infect Dis 1999;179:717-20.
-
(1999)
J Infect Dis
, vol.179
, pp. 717-720
-
-
Vittinghoff, E.1
Scheer, S.2
O'Malley, P.3
-
4
-
-
0141989150
-
-
Nutley, NJ and Durham, NC: Roche Laboratories Inc, and Trimeris, Inc; March
-
Fuzeon [enfuvirtide) package insert. Nutley, NJ and Durham, NC: Roche Laboratories Inc, and Trimeris, Inc; March 2003.
-
(2003)
Fuzeon [Enfuvirtide) Package Insert
-
-
-
5
-
-
0004074875
-
-
London: Pharmaceutical Press. Electronic version, Micromedex, Greenwood Village, Colo; Edition expired December
-
Sweetman S (Ed), Martindale: The Complete Drug Reference. London: Pharmaceutical Press. Electronic version, Micromedex, Greenwood Village, Colo; Edition expired December 2002.
-
(2002)
Martindale: The Complete Drug Reference
-
-
Sweetman, S.1
-
6
-
-
0343431526
-
Current evidence and future directions for targeting HIV entry
-
D'Souza MP, Cairns JS, Plaeger SF. Current evidence and future directions for targeting HIV entry. JAMA 2000;84:215-22.
-
(2000)
JAMA
, vol.84
, pp. 215-222
-
-
D'Souza, M.P.1
Cairns, J.S.2
Plaeger, S.F.3
-
7
-
-
0031729823
-
Potent suppression of HIV-1 replication in humans T-20, a peptide inhibitor of gp41-mediated virus entry
-
Kilby MJ, Hopkins S, Venetta TM, et al. Potent suppression of HIV-1 replication in humans T-20, a peptide inhibitor of gp41-mediated virus entry. Nature Medicine 1998;11:1302-7.
-
(1998)
Nature Medicine
, vol.11
, pp. 1302-1307
-
-
Kilby, M.J.1
Hopkins, S.2
Venetta, T.M.3
-
8
-
-
0141920005
-
Pentafuside (T-20), a novel inhibitor of HIV-1 fusion and infection, is synergistic when used in combination with reverse transcriptase (RT) and protease inhibitors (PI) in vitro
-
Barney S, Guthrie K, Davis D, et al. Pentafuside (T-20), a novel inhibitor of HIV-1 fusion and infection, is synergistic when used in combination with reverse transcriptase (RT) and protease inhibitors (PI) in vitro. Antiviral Res 1998;37:A54.
-
(1998)
Antiviral Res
, vol.37
-
-
Barney, S.1
Guthrie, K.2
Davis, D.3
-
9
-
-
0031883832
-
Determinants of human immunodeficiency virus type-1 resistance to gp41-derived inhibitory peptides
-
Rimsky LT, Shugars DC, Matthews TJ. Determinants of human immunodeficiency virus type-1 resistance to gp41-derived inhibitory peptides. J Virol 1998;72:986-93.
-
(1998)
J Virol
, vol.72
, pp. 986-993
-
-
Rimsky, L.T.1
Shugars, D.C.2
Matthews, T.J.3
-
10
-
-
0010459359
-
Virus sensitivity to T-20 and T-1249 is independent of coreceptor usage
-
Chicago, Ill, February 4-8; Abstract 473
-
Greenberg M, McDanal C, Stanfield-Oakley S, et al. Virus sensitivity to T-20 and T-1249 is independent of coreceptor usage. Presented at: 8th Conference on Retroviruses and opportunistic Infections (CROI), Chicago, Ill, February 4-8, 2001; Abstract 473.
-
(2001)
8th Conference on Retroviruses and Opportunistic Infections (CROI)
-
-
Greenberg, M.1
McDanal, C.2
Stanfield-Oakley, S.3
-
11
-
-
0012885271
-
Characterization of baseline and treatment-emergent resistance to T-20 (enfuvirtide) observed in Phase II clinical trials: Substitution in gp41 amino acids 36-45 and enfuvirtide susceptibility of virus isolates
-
Sista P, Melby T, Greenberg ML, et al. Characterization of baseline and treatment-emergent resistance to T-20 (enfuvirtide) observed in Phase II clinical trials: substitution in gp41 amino acids 36-45 and enfuvirtide susceptibility of virus isolates. Antiviral Ther 2002;7:S23.
-
(2002)
Antiviral Ther
, vol.7
-
-
Sista, P.1
Melby, T.2
Greenberg, M.L.3
-
12
-
-
0036090585
-
Emergence of resistant human immunodeficiency virus type 1 in patients receiving fusion inhibitor (T-20) monotherapy
-
Wei X, Decker JM, Liu H, et al. Emergence of resistant human immunodeficiency virus type 1 in patients receiving fusion inhibitor (T-20) monotherapy. Antimicrob Chemother 2002;46:1896-1905.
-
(2002)
Antimicrob Chemother
, vol.46
, pp. 1896-1905
-
-
Wei, X.1
Decker, J.M.2
Liu, H.3
-
13
-
-
0036066762
-
The safety, plasma pharmacokinetics, and antiviral activity of subcutaneous enfuvirtide (T-20), a peptide inhibitor of gp41-mediated virus fusion, in infected adults
-
Kilby MJ, Lalezari JP, Eron JJ, et al. The safety, plasma pharmacokinetics, and antiviral activity of subcutaneous enfuvirtide (T-20), a peptide inhibitor of gp41-mediated virus fusion, in infected adults. AIDS Research and Human Retroviruses 2002;18:685-93.
-
(2002)
AIDS Research and Human Retroviruses
, vol.18
, pp. 685-693
-
-
Kilby, M.J.1
Lalezari, J.P.2
Eron, J.J.3
-
14
-
-
1642294438
-
Correlation of gp41 binding and antiviral potencies of the fusion inhibitor T-20 using clinical trial isolate-derived sequences
-
Chicago, Ill, February 4-8; Abstract 474
-
Mink MA, Janumpalli S, Davison DK, et al. Correlation of gp41 binding and antiviral potencies of the fusion inhibitor T-20 using clinical trial isolate-derived sequences. Presented at: 8th Conference on retroviruses and Opportunistic Infections (CROI), Chicago, Ill, February 4-8, 2001; Abstract 474.
-
(2001)
8th Conference on Retroviruses and Opportunistic Infections (CROI)
-
-
Mink, M.A.1
Janumpalli, S.2
Davison, D.K.3
-
15
-
-
0037539498
-
Fitness of HIV-1 clinical isolates resistant to T-20 (enfuvirtide)
-
Lu J, Sista P, Cammack N, et al. Fitness of HIV-1 clinical isolates resistant to T-20 (enfuvirtide). Antiviral Ther 2002;7:S56.
-
(2002)
Antiviral Ther
, vol.7
-
-
Lu, J.1
Sista, P.2
Cammack, N.3
-
16
-
-
0035805185
-
Primary genotypic resistance of HIV-1 to the fusion inhibitor T-20 in long-term infected patients
-
Zollner B, Feucht HH, Schroter M, et al. Primary genotypic resistance of HIV-1 to the fusion inhibitor T-20 in long-term infected patients. AIDS 2001;15:935-6.
-
(2001)
AIDS
, vol.15
, pp. 935-936
-
-
Zollner, B.1
Feucht, H.H.2
Schroter, M.3
-
17
-
-
0037119027
-
Minimal variation in T-20 binding domain of different HIV subtypes from antiretroviral naïve and experienced patients
-
Xu L, Hue S, Taylor S, et al. Minimal variation in T-20 binding domain of different HIV subtypes from antiretroviral naïve and experienced patients. AIDS 2002;16:1684-6.
-
(2002)
AIDS
, vol.16
, pp. 1684-1686
-
-
Xu, L.1
Hue, S.2
Taylor, S.3
-
18
-
-
0034890660
-
Sensitivity of human immunodeficiency virus type 1 to fusion inhibitors targeted to the gp41 first heptad repeat involves distinct regions of gp41 and is consistently modulated by gp120 interactions with coreceptors
-
Derdeyn C, Decker JM, Sfakianos JN, et al. Sensitivity of human immunodeficiency virus type 1 to fusion inhibitors targeted to the gp41 first heptad repeat involves distinct regions of gp41 and is consistently modulated by gp120 interactions with coreceptors. J Virol 2001;75:8605-14.
-
(2001)
J Virol
, vol.75
, pp. 8605-8614
-
-
Derdeyn, C.1
Decker, J.M.2
Sfakianos, J.N.3
-
19
-
-
0036335809
-
Pharmacokinetics of the plasma enfuvirtide after subcutaneous administration to patients with human immunodeficiency virus: Inverse Gaussian density absorption and 2-compartmental disposition
-
Zhang X, Nieforth K, Lang JM, et al. Pharmacokinetics of the plasma enfuvirtide after subcutaneous administration to patients with human immunodeficiency virus: Inverse Gaussian density absorption and 2-compartmental disposition. Clin Pharmacol Ther 2002;72:10-19.
-
(2002)
Clin Pharmacol Ther
, vol.72
, pp. 10-19
-
-
Zhang, X.1
Nieforth, K.2
Lang, J.M.3
-
20
-
-
0009834687
-
Pharmacokinetics of selected doses of T-20, a fusion inhibitor, in HIV-1 infected children
-
Chicago, Ill, February 4-8; Abstract 726
-
Kosel B, et al, for the PACTG 1005 Study Team. Pharmacokinetics of selected doses of T-20, a fusion inhibitor, in HIV-1 infected children. Presented at: 8th Conference on Retroviruses and Opportunistic Infections (CROI), Chicago, Ill, February 4-8, 2001; Abstract 726.
-
(2001)
8th Conference on Retroviruses and Opportunistic Infections (CROI)
-
-
Kosel, B.1
-
21
-
-
0011059972
-
Pharmacokinetics and safety of 2 mg/kg T-20 in combination therapy in HIV infected children and adolescents
-
Barcelona, Spain, July 7-12; Poster TuPeB4632
-
Bellibas SE, Pepper T, Dorr A, et al. Pharmacokinetics and safety of 2 mg/kg T-20 in combination therapy in HIV infected children and adolescents. Presented at: XIV International AIDS Conference, Barcelona, Spain, July 7-12, 2002; Poster TuPeB4632.
-
(2002)
XIV International AIDS Conference
-
-
Bellibas, S.E.1
Pepper, T.2
Dorr, A.3
-
22
-
-
0141954435
-
Enfuvirtide (T-20) is optimally absorbed from three different subcutaneous injection sites
-
Barcelona, Spain, July 7-12; Poster TuPeB4542
-
Patel IH, Lalezari J, Dorr A, et al. Enfuvirtide (T-20) is optimally absorbed from three different subcutaneous injection sites. Presented at: XIV International AIDS Conference, Barcelona, Spain, July 7-12, 2002; Poster TuPeB4542.
-
(2002)
XIV International AIDS Conference
-
-
Patel, I.H.1
Lalezari, J.2
Dorr, A.3
-
23
-
-
0003265606
-
Safety, pharmacokinetics and antiviral activity of T-20 as a single agent in heavily pre-treated patients
-
Chicago, Ill, January 31-February 4; Abstract CB13
-
Lalezari J, Eron J, Carlson M, et al. Safety, pharmacokinetics and antiviral activity of T-20 as a single agent in heavily pre-treated patients. Presented at: 6th Conference on Retroviruses and Opportunistic Infections (CROI), Chicago, Ill, January 31-February 4, 1999; Abstract CB13.
-
(1999)
6th Conference on Retroviruses and Opportunistic Infections (CROI)
-
-
Lalezari, J.1
Eron, J.2
Carlson, M.3
-
24
-
-
0141786378
-
A week 48 assessment of a randomized, controlled, open-labeled phase II trial (T20-206) evaluating three doses of T-20 in PI-Experienced, NNRTI-naïve patients infected with HIV-1
-
Seattle, Wash, February 24-28; Abstract 418-W
-
Lalezari J, DeJesus E, Northfelt D, et al. A week 48 assessment of a randomized, controlled, open-labeled phase II trial (T20-206) Evaluating three doses of T-20 in PI-Experienced, NNRTI-naïve patients infected with HIV-1. Presented at: 9th Conference on Retroviruses and Opportunistic Infections (CROI), Seattle, Wash, February 24-28, 2002; Abstract 418-W.
-
(2002)
9th Conference on Retroviruses and Opportunistic Infections (CROI)
-
-
Lalezari, J.1
DeJesus, E.2
Northfelt, D.3
-
25
-
-
0003248156
-
48 Week assessment of high strength T-20 in multi-class experienced patients
-
Seattle, Wash, February; Poster 417-W
-
Wheat LJ, Lalezari J, Kilby M, et al. 48 week assessment of high strength T-20 in multi-class experienced patients. Presented at: 9th Conference on Retroviruses and Opportunistic Infections; Seattle, Wash, February 2002; Poster 417-W.
-
(2002)
9th Conference on Retroviruses and Opportunistic Infections
-
-
Wheat, L.J.1
Lalezari, J.2
Kilby, M.3
-
26
-
-
0003222780
-
Enfuvirtide (T-20) in combination with an optimized background (OB) regimen vs. OB alone in patients with prior experience or resistance to each of the three classes of approved antiretrovirals (ARVs) in Europe and Australia (TORO2)
-
Barcelona, Spain, July 7-12; Poster LbOr19A
-
Clotet B, Lazzarin A, Cooper D, et al. Enfuvirtide (T-20) in combination with an optimized background (OB) regimen vs. OB alone in patients with prior experience or resistance to each of the three classes of approved antiretrovirals (ARVs) in Europe and Australia (TORO2). Presented at: XIV International AIDS Conference; Barcelona, Spain, July 7-12, 2002; Poster LbOr19A.
-
(2002)
XIV International AIDS Conference
-
-
Clotet, B.1
Lazzarin, A.2
Cooper, D.3
-
27
-
-
0003243367
-
Enfuvirtide (T-20) in combination with an optimized background (OB) regimen vs OB alone in patients with prior experience or resistance to each of the three classes of approved antiretrovirals (ARVs) in North America and Brazil
-
Barcelona, Spain, July 7-12; Poster LbOr19B
-
Henry K, Lalezari J, O'Hearn M, et al. Enfuvirtide (T-20) in combination with an optimized background (OB) regimen vs OB alone in patients with prior experience or resistance to each of the three classes of approved antiretrovirals (ARVs) in North America and Brazil. Presented at: XIV International AIDS Conference, Barcelona, Spain, July 7-12, 2002; Poster LbOr19B.
-
(2002)
XIV International AIDS Conference
-
-
Henry, K.1
Lalezari, J.2
O'Hearn, M.3
-
28
-
-
0036020193
-
Safety and antiretroviral activity of chronic subcutaneous administration of T-20 in human immunodeficiency virus 1-infected children
-
Church JA, Cunningham C, Hughes M, et al. Safety and antiretroviral activity of chronic subcutaneous administration of T-20 in human immunodeficiency virus 1-infected children. Pediatr Infec Dis J 2002;21:653-9.
-
(2002)
Pediatr Infec Dis J
, vol.21
, pp. 653-659
-
-
Church, J.A.1
Cunningham, C.2
Hughes, M.3
-
30
-
-
0012013998
-
Enfuvirtide (T-20) in combination with an optimized background (OB) regimen vs. OB alone: Week 24 response among categories of treatment experience and baseline (BL) HIV antiretroviral (ARV) resistance
-
San Diego, Calif, September 27-30; Abstract H-1074
-
Lalezari JP, Henry K, O'Hearn M, et al. Enfuvirtide (T-20) in combination with an optimized background (OB) regimen vs. OB alone: Week 24 response among categories of treatment experience and baseline (BL) HIV antiretroviral (ARV) resistance. Presented at: 42nd Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC), San Diego, Calif, September 27-30, 2002; Abstract H-1074.
-
(2002)
42nd Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC)
-
-
Lalezari, J.P.1
Henry, K.2
O'Hearn, M.3
-
31
-
-
0141954433
-
Enfuvirtide (T-20) in combination with optimized background (OB) regimen vs. OB alone: Week 24 response among categories of baseline (BL) demographics, treatment experience and HIV antiretroviral (ARV) resistance
-
Glasgow, Scotland, November 17-21; Poster PL14.3
-
Lange J, Lazzarin A, Cloetet B, et al, on behalf of the TORO 2 Study Group. Enfuvirtide (T-20) in combination with optimized background (OB) regimen vs. OB alone: Week 24 response among categories of baseline (BL) demographics, treatment experience and HIV antiretroviral (ARV) resistance. Presented at: 6th International Congress on Drug Therapy in HIV Infection, Glasgow, Scotland, November 17-21, 2002; Poster PL14.3.
-
(2002)
6th International Congress on Drug Therapy in HIV Infection
-
-
Lange, J.1
Lazzarin, A.2
Cloetet, B.3
-
32
-
-
0011581041
-
Tolerability of enfuvirtide (T-20) during chronic therapy in Phase II trials
-
San Diego, Calif, September 27-30; Abstract H-171
-
Drobnes C, Fang L, Nelson E, et al. Tolerability of enfuvirtide (T-20) during chronic therapy in Phase II trials. Presented at: 42nd Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC), San Diego, Calif, September 27-30, 2002; Abstract H-171.
-
(2002)
42nd Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC)
-
-
Drobnes, C.1
Fang, L.2
Nelson, E.3
-
33
-
-
0037877259
-
Summary of pooled efficacy and safety analyses of enfuvirtide (ENF) treatment for 24 weeks in TORO 1 and TORO 2 phase III trials in highly antiretroviral (ARV) treatment-experienced patients
-
Boston, Mass, February; Poster 568
-
Delfraissy JF, Montaner J, Eron J, et al, for the TORO study team. Summary of pooled efficacy and safety analyses of enfuvirtide (ENF) treatment for 24 weeks in TORO 1 and TORO 2 phase III trials in highly antiretroviral (ARV) treatment-experienced patients. Presented at: 10th Conference on Retroviruses and Opportunistic Infections, Boston, Mass, February 2002; Poster 568.
-
(2002)
10th Conference on Retroviruses and Opportunistic Infections
-
-
Delfraissy, J.F.1
Montaner, J.2
Eron, J.3
-
34
-
-
0036315615
-
Long-term treatment with subcutaneous T-20, a fusion inhibitor, in HIV-infected patients: Patient satisfaction and impact on activities of daily living
-
Cohen CJ, Dusek A, Green J, et al. Long-term treatment with subcutaneous T-20, a fusion inhibitor, in HIV-infected patients: patient satisfaction and impact on activities of daily living. AIDS Patient Care and STDs 2002;16:327-35.
-
(2002)
AIDS Patient Care and STDs
, vol.16
, pp. 327-335
-
-
Cohen, C.J.1
Dusek, A.2
Green, J.3
-
35
-
-
0141989147
-
Patient survey on injection of enfuvirtide (T-20): Ease of use and impact on activities
-
Barcelona, Spain, July 7-12; Poster TuPeB4480
-
Green J, Salgo MP, Delehanty J. Patient survey on injection of enfuvirtide (T-20): ease of use and impact on activities. Presented at: XIV International AIDS Conference, Barcelona, Spain, July 7-12, 2002; Poster TuPeB4480.
-
(2002)
XIV International AIDS Conference
-
-
Green, J.1
Salgo, M.P.2
Delehanty, J.3
-
36
-
-
0141451457
-
Enfuvirtide-investigations on the drug interaction potential in HIV-infected patients
-
Boston, Mass, February; Poster 541
-
Boyd M, Ruxrungtham K, Zhang X, et al. Enfuvirtide-investigations on the drug interaction potential in HIV-infected patients. Presented at: 10th Conference on Retroviruses and Opportunistic Infections; Boston, Mass, February 2002; Poster 541.
-
(2002)
10th Conference on Retroviruses and Opportunistic Infections
-
-
Boyd, M.1
Ruxrungtham, K.2
Zhang, X.3
-
37
-
-
0035313589
-
Human immunodeficiency virus type 1 entry inhibitors PRO 542 and T-20 are synergistic in blocking virus-cell and cell-cell fusion
-
Nagashima KA, Thompson JA, Rosenfield SI, et al. Human immunodeficiency virus type 1 entry inhibitors PRO 542 and T-20 are synergistic in blocking virus-cell and cell-cell fusion. J Infect Dis 2001;183:1121-5.
-
(2001)
J Infect Dis
, vol.183
, pp. 1121-1125
-
-
Nagashima, K.A.1
Thompson, J.A.2
Rosenfield, S.I.3
-
38
-
-
0034298213
-
Strong in vitro synergy between the fusion inhibitor T-20 and the CXCR4 blocker AMD-3100
-
Tremblay CL, Kollmann C, Giguel F, et al. Strong in vitro synergy between the fusion inhibitor T-20 and the CXCR4 blocker AMD-3100. J Acquir Immune Defic Syndr 2000;25:99-102.
-
(2000)
J Acquir Immune Defic Syndr
, vol.25
, pp. 99-102
-
-
Tremblay, C.L.1
Kollmann, C.2
Giguel, F.3
-
39
-
-
0141954432
-
-
[Press release] Reuters; February 24
-
Record high price set for new Roche AIDS drug. [Press release]. Reuters; February 24, 2003. Accessed at: www.medscape.com/viewarticle/449798.
-
(2003)
Record High Price Set for New Roche AIDS Drug
-
-
|