The degradation of the antitumor agent gemcitabine hydrochloride in an acidic aqueous solution at pH 3.2 and identification of degradation products

Journal of Pharmaceutical Sciences

Volumn 89, Issue 7, 2000, Pages 885-891

  Jansen, Patrick J ^a   Akers, Michael J ^a   Amos, Robert M ^a   Baertschi, Steven W ^a   Cooke, Gary G ^a   Dorman, Douglas E ^a   Kemp, Craig A J ^a   Maple, Steven R ^a   McCune, Karen A ^a  

^a ELI LILLY AND COMPANY   (United States)

Author keywords

Arrhenius; Degradation; Gemcitabine; Kinetics

Indexed keywords

GEMCITABINE;

ANALYTIC METHOD; ANTINEOPLASTIC ACTIVITY; AQUEOUS SOLUTION; ARTICLE; DNA SYNTHESIS INHIBITION; DRUG DEGRADATION; DRUG ISOLATION; DRUG STABILITY; FIRST PASS EFFECT; FREEZE DRYING;

EID: 0033812959     PISSN: 00223549     EISSN: None     Source Type: Journal    
DOI: 10.1002/1520-6017(200007)89:7<885::AID-JPS5>3.0.CO;2-Q     Document Type: Article

References (9)

1. Gemcitabine - A review of its pharmacology and clinical potential in non-small cell lung cancer and pancreatic cancer
2. Structure of the photohydration products of cytidine and urinde
3. Diastereomers of uracil glycoside photohydrates
4. Photochemistry of cytosine derivatives. 2. Photohydration of cytosine derivatives. Proton magnetic resonance study on the chemical structure and property of photohydrates
5. O6,5'-Cyclo-5,6-dihydro-2'-deoxyuridine. Novel deoxyuridine photoproducts
6. Degradation chemistry of gemcitabine hydrochloride, a new antitumor agent
7. The mechanism of the deamination of cytidine
8. Comparative kinetics of cytosine nucleosides. Influences of a 6-methyl substituent on degradation rates and pathways in aqueous buffers
9. Intermolecular and intramolecular catalysis in deamination of cytosine nucleosides