2-OH-estradiol, an endogenous hormone with neuroprotective functions

Journal of Psychiatric Research

Volumn 37, Issue 6, 2003, Pages 517-523

  Teepker, Michael ^a   Anthes, Norman ^a   Krieg, Jürgen Christian ^a   Vedder, Helmut ^a  

^a PHILIPPS UNIVERSITY MARBURG   (Germany)

Author keywords

17 Estradiol; 2 Hydroxy estradiol; Hippocampal cells; Lipid peroxidation; Neuroprotection

Indexed keywords

CATECHOL ESTROGEN; ESTRADIOL; ESTRIOL; ESTROGEN RECEPTOR; HYDROGEN PEROXIDE; LIPID;

ANIMAL EXPERIMENT; ANIMAL TISSUE; CELL CULTURE; CELL DEATH; CELL LINE; CELL VIABILITY; COMPARATIVE STUDY; CONFERENCE PAPER; CONTROLLED STUDY; DISEASE ACTIVITY; HEALTH; HIPPOCAMPUS; HOMOGENATE; HORMONE ACTION; HUMAN; HUMAN CELL; INCUBATION TIME; LIPID PEROXIDATION; METABOLITE; NEUROPROTECTION; NONHUMAN; PRIORITY JOURNAL; RAT; STATISTICAL SIGNIFICANCE; TIME;

EID: 0141922965     PISSN: 00223956     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0022-3956(03)00068-2     Document Type: Conference Paper

References (35)

1. Banger M., Hiemke C., Knuppen R., Ball P., Haupt M., Wiedemann K. Formation and metabolism of catecholestrogens in depressed patients. Biological Psychiatry. 28:1990;685-696.
2. Behl C., Davis J.B., Cole G., Schubert D. Vitamin E protects nerve cells from amyloid-β-protein toxicity. Biochemical and Biophysical Research Communications. 186:1992;944-950.
3. Behl C., Davis J.B., Lesley R., Schubert D. Hydrogen peroxide mediates amyloid-β-protein toxicity. Cell. 77:1994;817-827.
4. Behl C., Widmann M., Trapp T., Holsboer F. 17-β-estradiol protects neurons from oxidative stress-induced cell death in vitro. Biochemical and Biophysical Research Communications. 216:1995;473-482.
5. Behl C., Skutella T., Lezoualc'h F., Post A., Widmann M., Newton C.J.et al. Neuroprotection against oxidative stress by estrogens: structure-activity relationship. Molecular Pharmacology. 51:1997;535-541.
6. Behl C., Manthey D. Neuroprotective activities of estrogen: an update. Journal of Neurocytology. 29:2000;351-358.
7. Bilici M., Efe H., Köroglu M., Uydu H.A., Bekaroglu M., Deger O. Antioxidative enzyme activities and lipid peroxidation in major depression: alterations by antidepressant treatments. Journal of Affective Disorders. 4:2001;43-51.
8. Culmsee C., Vedder H., Ravati A., Junker V., Otto D., Ahlmeyer B.et al. Neuroprotection by estrogens in a mouse model of focal cerebral ischemia and in cultured neurons: evidence for a receptor-independent antioxidative mechanism. Journal of Cerebral Blood Flow & Metabolism. 19:1999;1263-1289.
9. Davis J.B., Maher P. Protein kinase C activation inhibits glutamate-induced cytotoxicity in a neuronal cell line. Brain Research. 652:1994;169-173.
10. Dexter D.T., Holley A.E., Flitter W.D., Slater T.F., Wells F.R., Daniel S.E.et al. Increased levels of lipid hydroperoxides in the parkinsonian substantia nigra: an HPLC and ESR study. Movement Disorders. 9:1994;92-97.
11. Emons G., Merriam G.R., Pfeiffer D., Loriaux D.L., Ball P., Knuppen R. Metabolism of exogenous 4- and 2-hydroxyestradiol in the human male. J Steroid Biochem. 28(5):1987;499-504.
12. Etchegoyen G.S., Cardinali D.P., Perez A.E., Tamayo J., Perez-Palacios G. Binding and effects of catecholestrogens on adenylate cyclase activity, and adrenoceptors, benzodiazepine and GABA receptors in guinea-pig hypothalamic membranes. European Journal of Pharmacology. 129:1986;1-10.
13. Fishman J. Role of 2-hydroxyestrone in estrogen metabolism. The Journal of Clinical Endocrinology and Metabolism. 23:1963;207-210.
14. Hoppen H.H., Ball P., Hoogen H., Knuppen R. Metabolism of 2-hydroxyestrogen methyl esters in rat liver in vitro. Hoppe-Seyler's Zeitschrift fuer physiologische Chemie. 353:1973;771-780.
15. Komuro E., Takahashi M., Morita T., Tsuchiya J., Arakawa J., Niki E. Inhibition of peroxidation of lipids and membranes by estrogens. Journal of Physical Organic Chemistry. 3:1990;309-315.
16. Kuloglu M., Atmaca M., Tezcan A.E., Gecici Ö., Tunckol H., Ustungdag B. Antioxidant enzyme activities and malondialdehyde levels in patients with obsessive-compulsive disorder. Neuropsychobiology. 46:2002;27-32.
17. Kuloglu M., Ustundag B., Atmaca M., Canatan H., Tezcan A.E., Cinkilinc N. Lipid peroxidation and antioxidant enzyme levels in patients with schizophrenia and bipolar disorder. Cell Biochemistry and Function. 20:2002;171-175.
18. Kuroki Y., Fukushima K., Kanda Y., Mizuno K., Watanabe Y. Neuroprotection by estrogen via extracellular signal-regulated kinase against quinolinic acid-induced cell death in the rat hippocampus. Eur J Neurosci. 13(3):2001;472-476.
19. Lacort M., Leal A.M., Liza M., Martin C., Martinez R., Ruiz-Larrea M.B. Protective effects of estrogens and catecholestrogens against peroxidative membrane damage in vitro. Lipids. 30:1995;141-146.
20. Liehr J., Roy D. Free radical generation by redox cycling of estrogens. Free Radical Biology and Medicine. 8:1990;415-423.
21. Linford N., Wade C., Dorsa D. The rapid effects of estrogen are implicated in estrogen-mediated neuroprotection. Journal of Neurocytology. 29:2000;367-374.
22. Miura T., Muroaka S., Ogiso T. Inhibition of lipid peroxidation by estradiol and 2-hydroxyestradiol. Steroids. 61:1996;379-383.
23. Morimoto B.H., Koshland D.E. Induction and expression of long- and short-term neurosecretory potentiation in a neural cell line. Neuron. 5:1990;875-880.
24. Nakano M., Sugioka K., Naito I., Takekoshi S., Niki E. Novel and potent biological antioxidants on membrane phospholipid peroxidation: 2-hydroxy-estrone and 2-hydroxy-estradiol. Biochemical and Biophysical Research Communications. 138:1986;533-539.
25. Okhawa H., Oshishi N., Saito H., Katsuki H. Assay for lipid peroxidation by thiobarbituric acid reaction. Analytical Biochemistry. 95:1996;351-358.
26. Parvizi N., Ellendorff F. Recent review on endocrine effects of catecholestrogens. The Journal of Steroid Biochemistry and Molecular Biology. 12:1980;331-335.
27. Rifici V.A., Khachadurian A.K. The inhibition of low-density lipoprotein-oxidation by 17-β-estradiol. Metabolism. 41:1994;1110-1114.
28. Ruiz-Larrea B., Leal A., Lacort M., deGroot H. Antioxidant effects of estradiol and 2-hydroxyestradiol on iron-induced lipid peroxidation of rat liver microsomes. Steroids. 59:1994;383-388.
29. Ruiz-Larrea B., Leal A., Martin C., Martinez R., Lacort M. Effects of estrogens on the redox chemistry of iron: a possible mechanism of the antioxidant action of estrogens. Steroids. 60:1995;780-783.
30. Ruiz-Larrea B., Martin C., Martinez R., Navarro R., Lacort M. Antioxidant activities of estrogens against aqueous and lipophilic radicals; differences between phenol and catecholestrogens. Chemistry and Physics of Lipids. 105:2000;179-188.
31. Singer C.A., Figueroa-Masot X.A., Bachelor R.H., Dorsa D.M. The mitogen-activated protein kinase pathway mediates estrogen neuroprotection after glutamate toxicity in primary cortical neurons. The Journal of Neuroscience. 19:1999;2455-2463.
32. Subramanian M., Pusphendran C.K., Tarachand U., Devasagayam T.P. Gestation confers temporary resistance to peroxidation in the maternal rat brain. Neuroscience Letters. 155:1993;151-154.
33. Vandewalle B., Hornez L., Lefebvre J. Characterization of catecholestrogen membrane binding sites in estrogen receptor positive and negative human breast cancer cell-lines. Journal of Receptor Research. 8:1988;699-712.
34. Vedder H., Anthes N., Stumm G., Würz C., Behl C., Krieg J.C. Estrogen hormones reduce lipid peroxidation in cells and tissues of the central nervous system. Journal of Neurochemistry. 72:1999;2531-2538.
35. Vedder H., Teepker M., Fischer S., Krieg J.C. Characterization of the neuroprotective effects of estrogens on hydrogen peroxide-induced cell death in hippocampal HT22-cells: time- and dose-dependency. Experimental and Clinical Endocrinology and Diabetes. 108:2000;120-127.