Identification and characterization of mechanistically distinct inducers of γ-globin transcription

Biochemical Pharmacology

Volumn 66, Issue 9, 2003, Pages 1755-1768

  Haley, John D ^a   Smith, David E ^a   Schwedes, Janine ^a   Brennan, Richard ^a   Pearce, Cedric ^a   Moore, Claudia ^a   Wang, Faye ^a   Petti, Fillipo ^a   Grosveld, Frank ^b   Jane, Stephen M ^c   Noguchi, Constance T ^d   Schechter, Alan N ^d  

^a OSI PHARMACEUTICALS INC   (United States)

^b ERASMUS UNIVERSITY ROTTERDAM   (Netherlands)

^c ROYAL MELBOURNE HOSPITAL   (Australia)

^d NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES   (United States)

Author keywords

Globin switching; Histone deacetylase; Sickle disease; Globin transcription

Indexed keywords

GAMMA GLOBIN; HEMOGLOBIN F; HISTONE DEACETYLASE; HYDROXAMIC ACID; HYDROXYUREA; LUCIFERASE; PLANT EXTRACT; TETRAPEPTIDE;

ARTICLE; CELL CULTURE; CELL STRAIN K 562; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG EFFICACY; DRUG TOLERABILITY; ENZYME ACTIVITY; ENZYME INHIBITION; GENE CONTROL; GENE EXPRESSION; GENE LOCUS; GENE SEQUENCE; GENETIC CODE; GENETIC TRANSCRIPTION; GENETIC TRANSFECTION; HEMATOPOIETIC STEM CELL; HUMAN; HUMAN CELL; MOLECULAR MODEL; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN ANALYSIS; REPORTER GENE; SCREENING; STEM CELL; YEAST ARTIFICIAL CHROMOSOME;

EID: 0141922893     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-2952(03)00542-2     Document Type: Article

References (43)

1. Noguchi CT, Haley JD, Abraham DJ, Schechter AN. Inhibition of sickle hemoglobin polymerization as a basis for therapeutic approaches to sickle cell anemia. In: Abraham DJ, editor. Burger's medicinal chemistry and drug discovery. 6th ed., vol. 3. New York: Wiley; 2003.
2. Clegg J.B., Weatherall D.J. Thalassemia and malaria: new insights into an old problem. Proc. Assoc. Am. Physicians. 111:1999;278-282.
3. Stamatoyannopoulos G, Nienhuis AW. Hemoglobin switching. In: Stamatoyannopoulos G, Nienhuis AW, Majerus P, Varmus H, editors. The molecular basis of blood diseases. Philadelphia: WB Saunders; 1994. p. 107-55.
4. Berg P., Schechter A. The impact of molecular biology on the diagnosis and treatment of hemoglobin disorders. Mol. Genet. Med. 2:1992;1-38.
5. Chada K., Magram J., Constantini F. An embryonic pattern of expression of a human fetal globin gene in transgenic mice. Nature. 319:1986;685-689.
6. Chada K., Magram J., Raphael K., Radice G., Lacy E., Constantini F. Specific expression of a foreign beta-globin gene in erythroid cells of transgenic mice. Nature. 314:1985;377-380.
7. Kollias G., Wrighton N., Hurst J., Grosveld F. Regulated expression of human A gamma-, beta-, and hybrid gamma beta-globin genes in transgenic mice: manipulation of the developmental expression patterns. Cell. 46:1986;89-94.
8. Rutherford T., Nienhuis A.W. Human globin gene promoter sequences are sufficient for specific expression of a hybrid gene transfected into tissue culture cells. Mol. Cell. Biol. 7:1987;398-402.
9. Tuan D., Solomon W., Li Q., London I.M. The "beta-like-globin" gene domain in human erythroid cells. Proc. Natl. Acad Sci. U.S.A. 82:1985;6384-6388.
10. Grosveld F., van Assendelft G.B., Greaves D.R., Kollias G. Position-independent, high-level expression of the human beta-globin gene in transgenic mice. Cell. 51:1987;975-985.
11. Talbot D., Collis P., Antoniou M., Vidal M., Grosveld F., Greaves D.R. A dominant control region from the human beta-globin locus conferring integration site-independent gene expression. Nature. 338:1989;352-355.
12. Wijgerde M., Grosveld F., Fraser P. Transcription complex stability and chromatin dynamics in vivo. Nature. 377:1995;209-213.
13. Wood W.G. The complexities of beta globin gene regulation. Trends Genet. 12:1996;204-206.
14. Poillon W.N., Kim B., Rodgers G., Noguchi C., Schechter A. Sparing effect of hemoglobin F and hemoglobin A2 on the polymerization of hemoglobin S at physiologic ligand saturations. Proc. Natl. Acad Sci. U.S.A. 90:1993;5039-5043.
15. Atweh G.F., Sutton M., Nassif I., Boosalis V., Dover G.J., Wallenstein S., Wright E., McMahon L., Stamatoyannopoulos G., Faller D.V., Perrine S.P. Sustained induction of fetal hemoglobin by pulse butyrate therapy in sickle cell disease. Blood. 93:1999;1790-1797.
16. Noguchi C.T., Rodgers G., Serjeant G., Schechter A.N. Levels of fetal hemoglobin necessary for treatment of sickle cell disease. New Engl. J. Med. 318:1988;96-99.
17. Zhou W., Clouston D.R., Wang X., Cerruti L., Cunningham J.M., Jane S.M. Induction of human fetal globin gene expression by a novel erythroid factor, NF-E4. Mol. Cell. Biol. 20:2000;7662-7672.
18. Asano H., Li X., Stamatoyannopoulos G. FKLF a novel Kruppel-like factor that activates human embryonic and fetal beta-like globin genes. Mol. Cell. Biol. 19:1999;3571-3579.
19. Asano H., Li X., Stamatoyannopoulos G. FKLF-2: a novel Kruppel-like transcriptional factor that activates globin and other erythroid lineage genes. Blood. 95:2000;3578-3584.
20. Jane S.M., Nienhuis A.W., Cunningham J.M. Hemoglobin switching in man and chicken is mediated by a heteromeric complex between the ubiquitous transcription factor CP2 and a developmentally specific protein. EMBO J. 14:1995;97-105.
21. Yang Z., Engel J.D. Biochemical characterization of the developmental stage- and tissue-specific erythroid transcription factor, NF-E4. J. Biol. Chem. 269:1994;10079-10087.
22. Gumucio D.L., Rood K.L., Gray T.A., Riordan M.F., Sartor C.I., Collins F.S. Nuclear proteins that bind the human gamma-globin gene promoter: alterations in binding produced by point mutations associated with hereditary persistence of fetal hemoglobin. Mol. Cell. Biol. 8:1988;5310-5322.
23. Gumucio D.L., Shelton D.A., Zhu W., Millinoff D., Gray T., Bock J.H., Slightom J.L., Goodman M. Evolutionary strategies for the elucidation of cis and trans factors that regulate the developmental switching programs of the beta-like globin genes. Mol. Phylogenet. Evol. 5:1996;18-32.
24. McDonagh K.T., Lin H.J., Lowrey C.H., Bodine D.M., Nienhuis A.W. The upstream region of the human gamma-globin gene promoter. Identification and functional analysis of nuclear protein binding sites. J. Biol. Chem. 266:1991;11965-11974.
25. Turner J., Crossley M. Basic Kruppel-like factor functions within a network of interacting haematopoietic transcription factors. Int. J. Biochem. Cell Biol. 31:1999;1169-1174.
26. DeSimone J., Heller P., Hall I., Zwiers D. 5-Azacytidine stimulates fetal hemoglobin synthesis in anemic baboons. Proc. Natl. Acad Sci. U.S.A. 79:1982;4428-4431.
27. Koshy M., Dorn L., Bressler L., Molokie R., Lavelle D., Talischy N., Hoffman R., van Overveld W., DeSimone J. 2-Deoxy-5-azacytidine and fetal hemoglobin induction in sickle cell anemia. Blood. 96:2000;2379-2384.
28. Charache S., Terrin M.L., Moore R.D., Dover G.J., Barton F.B., Eckert S.V., McMahon R.P., Bonds D.R. Effect of hydroxyurea on the frequency of painful crises in sickle cell anemia. New Engl. J. Med. 332:1995;1317-1322.
29. Pace B.S., White G.L., Dover G.J., Boosalis M.S., Faller D.V., Perrine S.P. Short-chain fatty acid derivatives induce fetal globin expression and erythropoiesis in vivo. Blood. 100:2002;4640-4648.
30. Ney P., Sorrentino B., Lowrey C., Nienhuis A.W. Inducibility of the HS II enhancer depends on binding of an erythroid specific nuclear protein. Nucleic Acid Res. 18:1990;6011-6017.
31. de Wet J.R., Wood K., DeLuca M., Helinski D., Subramani S. Firefly luciferase gene: structure and expression in mammalian cells. Mol. Cell. Biol. 7:1987;725-737.
32. Grosveld F, Antoniou M, Berry M, deBoer E, Dillon N, Drabek D, Ellis J, Fraser P, Haley J, Philipsen S, Pruzina S, Raguz-Bolognesi S, Smith D, Trimbon T, Wijgerde M. Drug discovery and the transcriptional control of the human beta globin locus. In: Browne MJ, Thurlby PL, editors. Genomes, molecular biology and drug discovery. New York: Academic Press; 1996. p. 117-27.
33. Fibach E., Burke L.P., Schechter A., Noguchi C., Rodgers G. Hydroxyurea increases fetal hemoglobin in cultured erythroid cells derived from normal individuals and patients with sickle cell anemia or beta-thalassemia. Blood. 81:1993;1630-1635.
34. Holmes M., Haley J.D., Cerruti L., Zhou W.L., Zogos H., Smith D., Cunningham J.M., Jane S.M. Identification of Id2 as a globin regulatory protein by representational difference analysis of K562 cells induced to express gamma globin with a novel fungal compound. Mol. Cell. Biol. 19:1999;4182-4190.
35. Riggs M., Whittaker R., Neumann J., Ingram V. n-Butyrate causes histone modification in HeLa and Friend erythroleukaemia cells. Nature. 268:1977;462-464.
36. Mosser D.D., Theodorakis N.G., Morimoto R.I. Coordinate changes in heat shock element-binding activity and HSP70 gene transcription rates in human cells. Mol. Cell. Biol. 8:1988;4736-4744.
37. Luethy J.D., Holbrook N.J. Activation of the gadd153 promoter by genotoxic agents: a rapid and specific response to DNA damage. Cancer Res. 52:1992;5-10.
38. Prestera T., Talalay P. Electrophile and antioxidant regulation of enzymes that detoxify carcinogens. Proc. Natl. Acad. Sci. U.S.A. 92:1995;8965-8969.
39. Witt O., Monkemeyer S., Ronndahl G., Erdlenbruch B., Reinhardt D., Kanbach K., Pekrun A. Induction of fetal hemoglobin expression by the histone deacetylase inhibitor apicidin. Blood. 101:2003;2001-2007.
40. Darkin-Rattray S.J., Gurnett A.M., Myers R.W., Dulski P.M., Crumley T.M., Allocco J.J., Cannova C., Meinke P.T., Colletti S.L., Bednarek M.A., Singh S.B., Goetz M.A., Dombrowski A.W., Polishook J.D., Schmatz D.M. Apicidin: a novel antiprotozoal agent that inhibits parasite histone deacetylase. Proc. Natl. Acad. Sci. U.S.A. 93:1996;13143-13147.
41. Han J.W., Ahn S.H., Park S.H., Wang S.Y., Bae G.U., Seo D.W., Kwon H.K., Hong S., Lee H.Y., Lee Y.W., Lee H.W. Apicidin, a histone deacetylase inhibitor, inhibits proliferation of tumor cells via induction of p21WAF1/Cip1 and gelsolin. Cancer Res. 60:2000;6068-6074.
42. Park J.I., Choi H.S., Jeong J.S., Han J.Y., Kim I.H. Involvement of p38 kinase in hydroxyurea-induced differentiation of K562 cells. Cell Growth Diff. 12:2001;481-486.
43. Baliga B.S., Pace B.S., Chen H.H., Shah A.K., Yang Y.M. Mechanism for fetal hemoglobin induction by hydroxyurea in sickle cell erythroid progenitors. Am. J. Hematol. 65:2000;227-233.