Effects of low-dose cyclosporin on osteogenesis of human demineralized bone grafts in a surgically created mandibular defect in rats

Journal of Periodontology

Volumn 74, Issue 8, 2003, Pages 1136-1142

  Fu, Earl ^a   Tseng, Yueh Chin ^a   Shen, E Chin ^b   Hsieh, Yao Dung ^c   Chiang, Cheng Yang ^a  

^a NATIONAL DEFENSE MEDICAL CENTER   (Taiwan)

^b TAO YUAN GENERAL HOSPITAL   (Taiwan)

^c The 802 General Hospital   (Taiwan)

Author keywords

Bone regeneration; Bone, demineralized; Bone, freeze dried; Cyclosporin A; Grafts, bone; Osteogenesis

Indexed keywords

CYCLOSPORIN A; IMMUNOSUPPRESSIVE AGENT; MINERAL OIL;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BODY WEIGHT; BONE DEMINERALIZATION; BONE DEVELOPMENT; BONE GRAFT; BONE MATRIX; CARTILAGE; CONTROLLED STUDY; FREEZE DRYING; HISTOMETRY; HISTOPATHOLOGY; JAW MALFORMATION; LOW DRUG DOSE; MALE; NONHUMAN; OSSIFICATION; RAT; RAT STRAIN; SAMPLING; SOFT TISSUE; TISSUE REPAIR;

ALVEOLAR BONE LOSS; ANIMALS; BONE MATRIX; BONE TRANSPLANTATION; CHONDROGENESIS; CYCLOSPORINE; GRAFT REJECTION; HUMANS; IMMUNOSUPPRESSIVE AGENTS; MALE; ORAL SURGICAL PROCEDURES; OSTEOGENESIS; RATS; RATS, SPRAGUE-DAWLEY;

EID: 0141854106     PISSN: 00223492     EISSN: None     Source Type: Journal    
DOI: 10.1902/jop.2003.74.8.1136     Document Type: Article

References (57)

1. Mellonig JT, Bowers GM. Regenerating bone in clinical periodontics. J Am Dent Assoc 1990;121:497-502.
2. Aichelmann-Reidy ME, Yukna RA. Bone replacement grafts. The bone substitutes. Dent Clin North Am 1998;42:491-503.
3. Froum SJ, Ortiz M, Witkin RT, Thaler R, Scopp IW, Stahl SS. Osseous autografts. III. Comparison of osseous coagulum-bone blend implants with open curettage. J Periodontol 1976;47:287-294.
4. Mellonig JT. Autogenous and allogeneic bone grafts in periodontal therapy. Crit Rev Oral Biol Med 1992;3: 333-352.
5. Mellonig JT. Bone allografts in periodontal therapy. Clin Orthop 1996;324:116-125.
6. Urist MR. Bone: Formation by autoinduction. Science 1965;150:893-899.
7. Yeomans JD, Urist MR. Bone induction by decalcified dentine implanted into oral, osseous and muscle tissues. Arch Oral Biol 1967;12:999-1008.
8. Urist MR, Dowell TA, Hay PH, Strates BS. Inductive substrates for bone formation. Clin Orthop 1968;59: 59-96.
9. Urist MR, Dowell TA. Inductive substratum for osteogenesis in pellets of particulate bone matrix. Clin Orthop 1968;61:61-78.
10. Libin BM, Ward HL, Fishman L. Decalcified, lyophilized bone allografts for use in human periodontal defects. J Periodontol 1975;46:51-56.
11. Mellonig JT. Decalcified freeze-dried bone allograft as an implant material in human periodontal defects. Int J Periodontics Restorative Dent 1984;4(6):40-55.
12. Mellonig JT, Bowers GM, Bright RW, Lawrence JJ. Clinical evaluation of freeze-dried bone allografts in periodontal osseous defects. J Periodontol 1976;47:125-131.
13. Quintero G, Mellonig JT, Gambill VM, Pelleu GB Jr. A six-month clinical evaluation of decalcified freeze-dried bone allografts in periodontal osseous defects. J Periodontol 1982;53:726-730.
14. Bowers GM, Chadroff B, Carnevale R, et al. Histologic evaluation of new attachment apparatus formation in humans. Part I. J Periodontol 1989;60:664-674.
15. Bowers GM, Chadroff B, Carnevale R, et al. Histologic evaluation of new attachment apparatus formation in humans. Part II. J Periodontol 1989;60:675-682.
16. Bowers GM, Chadroff B, Carnevale R, et al. Histologic evaluation of new attachment apparatus formation in humans. Part III. J Periodontol 1989;60:683-693.
17. Werbitt MJ, Goldberg PV. The immediate implant: Bone preservation and bone regeneration. Int J Periodontics Restorative Dent 1992;12:206-217.
18. Shanaman RH. The use of guided tissue regeneration to facilitate ideal prosthetic placement of implants. Int J Periodontics Restorative Dent 1992;12:256-265.
19. Mellonig JT, Triplett RG. Guided tissue regeneration and endosseous dental implants. Int J Periodontics Restorative Dent 1993;13:108-119.
20. Nevins M, Mellonig JT. Enhancement of the damaged edentulous ridge to receive dental implants: A combination of allograft and the Gore-Tex membrane. Int J Periodontics Restorative Dent 1992;12:96-111.
21. Levine SS, Prewett AB, Cook SD. The use of a new form of allograft bone in implantation or osseointegrated dental implants - A preliminary report. J Oral Implantol 1992;18:366-371.
22. Torricelli P, Fini M, Rocca M, Giavaresi G, Giardino R. Xenogenic demineralized bone matrix: Osteoinduction and influence of associated skeletal defects in heterotopic bone formation in rats. Int Orthop 1999;23:178-181.
23. Pinholt EM, Bang G, Haanaes HR. Alveolar ridge augmentation in rats by Bio-Oss. Scand J Dent Res 1991; 99:154-161.
24. Block JE, Poser J. Does xenogeneic demineralized bone matrix have clinical utility as a bone graft substitute? Med Hypotheses 1995;45:27-32.
25. Richardson CR, Mellonig JT, Brunsvold MA, McDonnell HT, Cochran DL. Clinical evaluation of Bio-Oss: A bovine-derived xenograft for the treatment of periodontal osseous defects in humans. J Clin Periodontol 1999; 26:421-428.
26. Janovec M, Dvorak K. Autolyzed antigen-extracted allogeneic bone for bridging segmented diaphyseal bone defects in rabbits. Clin Orthop 1988;229:249-256.
27. Kubler N, Reuther J, Kirchner T, Priessnitz B, Sebald W. Osteoinductive, morphologic, and biomechanical properties of autolyzed, antigen-extracted, allogeneic human bone. J Oral Maxillofac Surg 1993;51:1346-1357.
28. Kirchner T, Pfaff M, Muller-Hermelink HK, Albert R, Sebald W. IgG monoclonal antibodies that inhibit osteoinductivity of human bone matrix-derived proteins (hBMP/NCP). Int J Oral Maxillofac Surg 1994;23: 420-422.
29. Sun L, Hu Y, Ning Z, Liang Z. The correlation between immune rejection and osteoinduction of allogeneic bone grafting. Chin Med J 1998;111:818-822.
30. Kaufmann Y, Chang AE, Robb RJ, Rosenberg SA. Mechanism of cyclosporin A: Inhibition of lymphokine secretion studied with antigen stimulated T cell hybridomas. J Immunol 1984;133:3107-3111.
31. Bunjes D, Hardt C, Rollinghoff H, Wagner H. Cyclosporin A mediates immunosuppression of primary cytotoxic T cell responses by impairing the release of interleukin 1 and interleukin 2. Eur J Immunol 1981;11:657-661.
32. Calne RY, Rolles K, Thiru S, et al. Cyclosporin A initially as the only immunosuppressant 34 recipients of cadaveric organs: 32 kidneys, 2 pancreases and 2 livers. Lancet 1979;2:1033-1036.
33. Brugnami F, Then PR, Moroi H, Leone CW. Histologic evaluation of human extraction sockets treated with demineralized freeze-dried bone allograft (DFDBA) and cell occlusive membrane. J Periodontol 1996;67: 821-825.
34. Becker W, Urist M, Becker BE et al. Clinical and histologic observations of sites implanted with intraoral autologous bone grafts or allografts. 15 human case reports. J Periodontol 1996;67:1025-1033.
35. Carnes DL Jr, De La Fontaine J, Cochran DL, et al. Evaluation of 2 novel approaches for assessing the ability of demineralized freeze-dried bone allograft to induce new bone formation. J Periodontol 1999;70:353-363.
36. Schwartz Z, Somers A, Mellonig JT, et al. Ability of commercial demineralized freeze-dried bone allograft to induce new bone formation is dependent on donor age but not gender. J Periodontol 1998;69:470-478.
37. Schwartz Z, Somers A, Mellonig JT, et al. Addition of human recombinant bone morphogenetic protein-2 to inactive commercial human demineralized freeze-dried bone allograft makes an effective composite bone inductive implant material. J Periodontol 1998;69:1337-1345.
38. Aspenberg P, Lohmander LS, Thorngren KG. Failure of bone induction by bone matrix in adult monkeys. J Bone Joint Surg 1988;70:625-627.
39. Wilmink JM, Bras J, Surachno S, van Heyst JL, van der Horst JM. Bone repair in cyclosporin-treated renal transplant patients. Transplant Proc 1989;21:1492-1494.
40. Bonnin MR, Gonzalez MT, Grino JM, et al. Changes in serum osteocalcin levels in the follow-up of kidney transplantation. Ann Clin Biochem 1997;34:651-655.
41. Withold W, Wolf HH, Kollbach S, Heyll A, Schneider W, Reinauer H. Monitoring of bone metabolism after bone marrow transplantation by measuring two different markers of bone turnover. Eur J Clin Chem Clin Biochem 1996;34:193-197.
42. Withold W, Degenhardt S, Castelli D, Heins M, Grabensee B. Monitoring of osteoblast activity with an immunoradiometric assay for determination of bone alkaline phosphatase mass concentration in patients receiving renal transplants. Clinica Chimica Acta 1994; 225:137-146.
43. Shen EC, Fu E, Hsieh YD. Effects of cyclosporin on dental alveolar bone: A histometric study in rats. J Periodontol 2001;72:659-665.
44. Fu E, Hsieh YD, Mao TK, Shen EC. The effect of cyclosporin on the trabecular bone of mandibular condyle: A histomorphological study in the rats. Arch Oral Biol 2001;46:1105-1110.
45. Epstein S, Schlosberg M, Fallon M, et al. 1,25-dihydroxy-vitamin D3 modifies cyclosporin-induced bone loss. Calcif Tissue Int 1990;47:152-157.
46. Movsowitz C, Epstein S, Fallon M, Ismail F, Thomas S. Cyclosporin-A in vivo produces severe osteopenia in the rats: Effect of dose and duration of administration. Endocrinology 1988;123:2571-2577.
47. Schlosberg M, Movsowitz C, Epstein S, Ismail F, Fallon M, Thomas S. The effect of cyclosporin A administration and its withdrawal on bone mineral metabolism in the rat. Endocrinology 1989;124:2179-2184.
48. Orcel P, Bielakoff J, Modrowski C, Miravet L, deVernejoul MC. Cyclosporin A induces in vivo inhibition of resorption and stimulation of formation in rat bone. J Bone Miner Res 1989;4:387-391.
49. del Pozo E, Elford P, Perrelet R, et al. Prevention of adjuvant arthritis by cyclosporine in rats. Semin Arthritis Rheum 1992;21:23-29.
50. Chowdhury MH, Shen V, Dempster DW. Effects of cyclosporine A on chick osteoclasts in vitro. Calcif Tissue Int 1991;49:275-279.
51. Klaushofer K, Hoffman O, Stewart PJ, et al. Cyclosporine A inhibits bone resorption in cultured neonatal mouse calvaria. J Pharmacol Exp Ther 1987;243:584-590.
52. Stewart PJ, Green OC, Stern PH. Cyclosporine A inhibits calcemic hormone-induced bone resorption in vitro. J Bone Miner Res 1986;1:285-291.
53. McCauley LK, Rosol TJ, Stromberg PC, Capen CC. Effects of interleukin-1 alpha and cyclosporin A in vivo and in vitro on bone and lymphoid tissues in mice. Toxicol Pathol 1991;19:1-10.
54. Marusic A, Dikic I, Vukicevic S, Marusic M. New bone induction by demineralized bone matrix in immunosuppressed rats. Experientia 1992;48:783-785.
55. Ekelund A, Nilsson OS. Effects of cyclosporin A on experimental new bone formation in rats. Clin Orthop 1992;284:288-298.
56. Ekelund A, Ahmed M, Bjurholm A, Nilsson O. Neuropeptides in heterotopic bone induced by bone matrix in immunosuppressed rats. Clin Orthop 1997;345:229-238.
57. Ekelund A, Aspenberg P, Nilsson O. No effect of immunosuppression with cyclosporin A detected on bone ingrowth into cancellous allo- and xenografts in the rat. Acta Orthop Scand 1999;70:491-496.