Neuropeptides in heterotopic bone induced by bone matrix in immunosuppressed rats

Clinical Orthopaedics and Related Research

Volumn 345, Issue , 1997, Pages 229-238

  Ekelund, Anders ^a   Ahmed, Mahmood ^b   Bjurholm, Anders ^b   Nilsson, Olle ^c  

^a ST GÖRAN S HOSPITAL   (Sweden)

^b KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

^c UPPSALA UNIVERSITY HOSPITAL   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

CALCITONIN GENE RELATED PEPTIDE; CYCLOSPORIN A; NEUROPEPTIDE; NEUROPEPTIDE Y; SUBSTANCE P; TYROSINE 3 MONOOXYGENASE; VASOACTIVE INTESTINAL POLYPEPTIDE;

ALLOGRAFT; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BONE; BONE MATRIX; CONTROLLED STUDY; DEMINERALIZATION; ECTOPIC TISSUE; IMMUNE RESPONSE; IMMUNOHISTOCHEMISTRY; IMMUNOSUPPRESSIVE TREATMENT; INNERVATION; INTRAPERITONEAL DRUG ADMINISTRATION; MALE; NONHUMAN; PRIORITY JOURNAL; RABBIT; RAT; XENOGRAFT;

EID: 0031469112     PISSN: 0009921X     EISSN: 15281132     Source Type: Journal    
DOI: 10.1097/00003086-199712000-00033     Document Type: Article

References (51)

1. Ahmed M, Bjurholm A, Schultzberg M, Theodorsson E, Kreicbergs A: Increased levels of substance P and calcitonin gene-related peptide in rat adjuvant arthritis A combined immunohistochemical and radioimmunoassay analysis. Arthritis Rheum 38:699-709, 1995.
2. Aspenberg P, Lohmander LS: Fibroblast growth factor stimulates bone formation: Bone induction studied in rats. Acta Orthop Scand 60:473-476, 1989.
3. Aspenberg P, Lohmander LS, Thorngren K-G: Failure of bone induction by bone matrix in adult monkeys. J Bone Joint Surg 70B:625-627, 1988.
4. Aspenberg P, Thorngren K-G, Lohmander LS: Rabbit bone matrix induces bone in the athymic rat. Acta Orthop Scand 59:276-278, 1988.
5. Bertolini DR, Nedwin GE, Bringman TS, Smith DD, Mundy GR: Stimulation of bone resorption and inhibition of bone formation in vitro by human tumour necrosis factors. Nature 319:516-518, 1986.
6. Bjurholm A, Kreicbergs A, Brodin E, Schultzberg M: Substance P- and CGRP-immunoreactwe nerves in bone. Peptides 9:165-171, 1988.
7. Bjurholm A, Kreicbergs A, Dahlberg I, Schultzberg M: The occurrence of neuropeptides at ditterent stages of DBM induced heterotopic bone formation. Bone Miner 10:95-107, 1990.
8. Bjurholm A, Kreicbergs A, Schultzberg M, Lerner U: Parathyroid hormone and noradrenaline induced enhancement of cyclic AMP in a cloned osteogenic sarcoma cell line (UMR 106) is inhibited by neuropeptide Y. Acta Physiol Scand 134:451-452, 1988.
9. Bjurholm A, Kreicbergs A, Terenius L, Goldstein M, Schultzberg M: Neuropeptide Y-. tyrosine hydroxylase- and vasoactive intestinal polypeptide-immunoreactive nerves in bone and surrounding tissues. J Auton Nerv Syst 25:119-125, 1988.
10. Borel JF, Baumann G, Chapman I, et al: In vivo pharmacological effects of Ciclosporin and some analogues. Adv Pharmacol 35:115-246, 1996.
11. Bos GD, Goldberg VM, Zika JM, Heiple KG, Powell AE: Immune responses of rats to frozen bone grafts. J Bone Joint Surg 65A:239-246, 1983.
12. Burchardt H, Glowczewskie FP, Enneking WF: Short-term immunosuppression with fresh segmental fibular allografts in dogs. J Bone Joint Surg 63A:411-415, 1981.
13. Calne RY, Rolles K, White DJG, et al: Cyclosporin A initially as the only immunosuppressant in 34 recipients of cadaveric organs: 32 kidneys, 2 pancreases, and 2 livers. Lancet 2:1033-1036, 1979.
14. Canalis E, McCarthy T, Centrella M: Growth factors and the regulation of bone remodeling. J Clin Invest 81:277-281, 1988.
15. Coffey RG, Hadden W: Neurotransmitters, hormones and cyclic nucleotides in lymphocyte regulation. Fed Proc 44:112-117, 1985.
16. Coons AH: Fluorescent Antibody Method. In Danelli F (ed). General Cytochemical Methods. New York, Academic Press 399-422, 1958.
17. D'Souza M, MacIntyre I, Girgis I, Mundy GR: Human synthetic calcitonin gene-related peptide inhibits bone resorption. Endocrinology 119:58-61, 1986.
18. Ekelund A, Nilsson OS: Effects of cyclosporin A on experimental new bone formation in rats. Clin Orthop 284:288-298, 1992.
19. Ekelund A, Nilsson OS: Effects of cyclosporin A on bone turnover and on resorption of demineralized bone matrix. Clin Orthop 326:127-134, 1996.
20. Elliot JF, Lin Y, Mizel SB, et al: Induction of interleukin 2 messenger RNA inhibited by cyclosporin A. Science 226:1439-1441, 1984.
21. Elves MW: Humoral immune response to allografts of bone. Int Arch Allergy Appl Immunol 47: 708-715, 1974.
22. Evans DB, Bunning RA, Russell RG: The effects of recombinant human interleukin-1 beta on cellular proliferation and the production of prostaglandin E2, plasminogen activator, osteocalcin and alkaline phosphatase by osteoblast-like cells derived from human bone. Biochem Biophys Res Comm 166:208-216, 1990.
23. Evans DB, Bunning RA, Van Damme J, Russell RG: Natural human IL-1 beta exhibits regulatory actions on human bone-derived cells in vitro. Biochem Biophys Res Commun 159:1242-1248, 1989.
24. Felten DL, Feiten SY, Bellinger DL, et al: Noradrenergic sympathetic neural interactions with the immune system: Structure and function. Immunol Rev 100:225-260, 1987.
25. Felten SY, Olschowka J: Noradrenergic sympathetic innervation of the spleen: II. Tyrosine hydroxylase (TH)-positive nerve terminals for synaptical-like contacts on lymphocytes in the splenic white pulp. J Neurosci 18:37-48, 1987.
26. Goldbera VM, Bos GD, Heiple KD, Zika JM, Powell AE: Improved acceptance ot frozen bone allografts in genetically mismatched dogs by immunosuppression. J Bone Joint Surg 66A:937-950, 1984.
27. Gowen M, Chapman K, Littlewood A, et al: Production of tumor necrosis factor by human osteoblasts is modulated by other cytokines, but not by osteotropic hormones. Endocrinology 126:1250-1255, 1990.
28. Gunn HC, Varey A, Cooke A: Effect of cyclosporin A on the function of T cells. Transplantation 32: 338-340, 1981.
29. Heath JK, Saklatvala J, Meikle MC, Atkinson SJ, Reynolds JJ: Pig interleukin 1 (Catabolin) is a potent stimulator of bone resorption. Calcif Tissue Int 37: 95-97, 1985.
30. Hess AD, Tutschka PJ, Santos GW: Effect of cyclosporine on the induction of cytotoxic T lymphocytes: Role of interleukin-1 and interleukin-2. Transplant Proc 15:2248-2258, 1983.
31. Hohmann EL, Tashjian Jr AH: Functional receptors for vasoactive intestinal polypeptide on human osteosarcoma cells. Endocrinology 114:1321-1327, 1984.
32. Horowitz MC, Friedlaender GE: Analysis of the immune response to bone allografts. Trans Orthop Res Soc 14:267, 1989.
33. Hukkanen M, Konttinen YT, Santavirta S, et al: Rapid proliferation of calcitonin gene related peptide immunoreactive nerves during healing of rat tibial fracture suggests neural involvement in bone growth and remodelling. Neuroscience 54:969-979, 1993.
34. Johnson DG, De Nogueira-Araujo GM: A simple method of reducing the fading of immunofluorescence during microscopy. J Immunol Methods 43:349-350, 1981.
35. Konttinen YT, Hukkanen M, Segerberg M, et al: Relationship between neuropeptide immunoreactive nerves and inflammatory cells in adjuvant arthritic rats. Scand J Rheum 21:55-59, 1992.
36. Levine JD, Clark R, Devor C, et al: Intraneuronal substance P contributes to the severity of experimental arthritis. Science 226:547-549, 1984.
37. Mahy PR, Urist MR: Experimental heterotopic bone formation induced by bone morphogenetic protein and recombinant human interleukin-1B. Clin Orthop 237:236-244, 1988.
38. Movsowitz C, Epstein S, Fallon M, Ismail F, Thomas S: Cyclosporin-A in vivo produces severe osteopenia in the rat: Effect of dose and duration of administration. Endocrinology 123:2571-2577, 1988.
39. Nilsson OS, Bauer HCF, Brosjö O, Törnkvist H: Influence of indomethacin on induced heterotopic bone formation in rats. Clin Orthop 207:239-245, 1986.
40. Nilsson OS, Persson P-E, Ekelund A: Heterotopic new bone formation causes resorption of the inductive bone matrix. Clin Orthop 257:280-285, 1990.
41. Orcel P, Bielakoff J, Modrowski D, Miravet L, De Vernejoul MC: Cyclosporin A induces in vivo inhibition of resorption and stimulation of formation in rat bone. J Bone Miner Res 4:387-391, 1989.
42. Russell RG, Graveley R, Seid J, al-Humidan AK, Skjodt H: Mechanisms of action of cyclosporine and effects on connective tissues. Semin Arthritis Rheum 21(Suppl 3):16-22, 1992.
43. Russell RG, Graveley R, Coxon F, et al: Cyclosporin A. Mode of action and effects on bone and joint tissues. Scand J Rheumatol 95(Suppl):9-18, 1992.
44. Sisask G, Bjurholm A, Ahmed M, Kreicbergs A: The ontogeny of sensory nerves in the developing skeleton. Anat Rec 243:234-240, 1995.
45. Stevenson S: The immune response to osteochondral allografts in dogs. J Bone Joint Surg 69A: 573-582, 1987.
46. Troiano N, Freedman D, Friedlaender GE: Cyclosporin A induced changes in bone biology. Trans Orthop Res Soc 572, 1992.
47. Urist MR: Bone formation by autoinduction. Science 150:893-899, 1965.
48. Urist MR: Bone morphogenetic protein, bone regeneration, heterotopic ossification and the bone - bone marrow consortium. J Bone Miner Res 6:57-112, 1989.
49. Urist MR, DeLange RJ, Finerman GAM: Bone cell differentiation and growth factors. Science 220: 680-685, 1983.
50. Urist MR, Nilsson OS, Hudak R, et al: Immunologic evidence of a bone morphogenetic protein in the milieu interieur. Ann Biol Clin 43:755-766, 1985.
51. Zaidi M, Fuller K, Bevis PJR, et al: Calcitonin gene related peptide inhibits bone resorption: A comparative study. Calcif Tissue Int 40:149-154, 1987.