Hepatoid adenocarcinoma with liver metastasis mimicking hepatocellular carcinoma: An immunohistochemical and molecular study of eight cases

American Journal of Surgical Pathology

Volumn 27, Issue 10, 2003, Pages 1302-1312

  Terracciano, Luigi M ^a,d   Glatz, Kathrin ^a   Mhawech, Paulette ^a,e   Vasei, Mahommad ^b   Lehmann, Frank S ^a   Vecchione, Raffaela ^c   Tornillo, Luigi ^a  

^a UNIVERSITY HOSPITAL BASEL   (Switzerland)

^b SHIRAZ UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^c FEDERICO II UNIVERSITY HOSPITAL   (Italy)

^d UNIVERSITY HOSPITAL BASEL   (Switzerland)

^e UNIVERSITY OF GENEVA   (Switzerland)

Author keywords

Comparative genomic hybridization; Hepatocellular carcinoma; Hepatoid adenocarcinoma; HepPar1; Immunohistochemistry; Liver biopsy; Tissue microarray

Indexed keywords

ALPHA FETOPROTEIN; CARCINOEMBRYONIC ANTIGEN; CYTOKERATIN 18; CYTOKERATIN 19; CYTOKERATIN 20; CYTOKERATIN 7; CYTOKERATIN 8; HEPATOCYTE PARAFFIN 1; PROTEIN; PROTEIN HEPPAR1; UNCLASSIFIED DRUG;

ADENOCARCINOMA; ADULT; AGED; AGGRESSION; AGING; ANTIBODY DETECTION; ANTIGEN DETECTION; ARTICLE; BILE DUCT CARCINOMA; CELL DIFFERENTIATION; CHROMOSOME 4Q; CHROMOSOME 8P; CHROMOSOME XQ; CLINICAL ARTICLE; CLINICAL FEATURE; COMPARATIVE GENOMIC HYBRIDIZATION; CONTROLLED STUDY; DIAGNOSTIC VALUE; DNA MICROARRAY; FEMALE; HEPATOBLASTOMA; HEPATOID ADENOCARCINOMA; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; LIVER CELL CARCINOMA; LIVER METASTASIS; LIVER TUMOR; LUNG CARCINOMA; MALE; METASTASIS; MOLECULAR BIOLOGY; PATHOLOGICAL ANATOMY; PROTEIN ANALYSIS; RISK FACTOR; STOMACH CARCINOMA;

ADENOCARCINOMA; AGED; ANTIBODIES, MONOCLONAL; CARCINOMA, HEPATOCELLULAR; DIAGNOSIS, DIFFERENTIAL; FEMALE; HUMANS; IMMUNOHISTOCHEMISTRY; LIVER NEOPLASMS; LUNG NEOPLASMS; MALE; MIDDLE AGED; NUCLEIC ACID HYBRIDIZATION; STOMACH NEOPLASMS; TUMOR MARKERS, BIOLOGICAL;

EID: 0141794483     PISSN: 01475185     EISSN: None     Source Type: Journal    
DOI: 10.1097/00000478-200310000-00002     Document Type: Article

References (56)

1. Aizawa K, Motoyama T, Suzuki S, et al. Different characteristics of hepatoid and non-hepatoid α-fetoprotein-producing gastric carcinomas: an experimental study using xenografted tumors. Int J Cancer. 1994;58:430-435.
2. Arnould L, Drouot F, Fargeot P, et al. Hepatoid adenocarcinoma of the lung: report of a case of an unusual α-fetoprotein-producing lung tumor. Am J Surg Pathol. 1997;21:1113-1118.
3. Bralet MP, Regimbeau JM, Pincau P, et al. Hepatocellular carcinoma occurring in nonfibrotic liver: epidemiologic and histopathologic analysis of 80 French cases. Hepatology. 2000;32:200-204.
4. Burgués O, Ferrer J, Navarro S, et al. Hepatoid adenocarcinoma of the urinary bladder: an unusual neoplasm. Virchows Arch. 1999:435:71-75.
5. Carlinfante G, Foschini MP, Pasquinelli G, et al. Hepatoid carcinoma of the lung: a case repon with immunohistochemical, ultrastructural and in-situ hybridization findings. Histopathology. 2000;37:85-94.
6. Chang YC, Nagasue N, Abe S, et al. α-Fetoprotein producing early gastric cancer with liver metastasis: report of three cases. Gut. 1991;32:542-545.
7. Chang YC, Nagasue N, Abe S, et al. Comparison between the clinicopathologic features of AFP-positive and AFP-negative gastric cancers. Am J Gastroenterol. 1992;87:321-325.
8. Chu PG, Ishizawa S, Wu E, et al. Hepatocyte antigen as a marker of hepatocellular carcinoma: an immunohistochemical comparison to carcino-embryonic antigen, CD10, and alpha-fetoprotein. Am J Surg Pathol. 2002;26:978-988.
9. Cingolani N, Shaco-Levy R, Farruggio A, et al. Alpha-fetoprotein production by pancreatic tumors exhibiting acinar cell differentiation: study of five cases, one arising in a mediastinal teratoma. Hum Pathol. 2000;31:938-944.
10. Devouassoux-Shisheboran M, Schammel DP, Tavassoli FA. Ovarian hepatoid yolk sac tumours: morphological, immunohistochemical and ultrastructural features. Histopathology. 1999;34:462-469.
11. Fan Z, van de Rijn M, Rouse R. Hep Par 1 stain for the differential diagnosis of hepatocellular carcinoma: 613 tumors tested using tissue microarrays and conventional tissue sections. Mod Pathol. 2002;15:283A.
12. Fasano M, Theise ND, Nalesnik M, et al. Immunohistochemical evaluation of hepatoblastomas with use of the hepatocyte-specific marker, Hepatocyte Paraffin 1, and the polyclonal anti-carcinoembryonic antigen. Mod Pathol. 1998;11:934-938.
13. Foschini MP, Baccarini P, Dal Monte PR, et al. Albumin gene expression in adenocarcinomas with hepatoid differentiation. Virchows Arch. 1998;433:537-541.
14. Garcia RL, Ghali VS. Gastric choriocarcinoma and yolk sac tumor in a man: observation about its possible origin. Hum Pathol. 1985;16:955-958.
15. Gardiner GW, Lajoie G, Keith R. Hepatoid adenocarcinoma of the papilla of Vater. Histopathology. 1992;20:541-544.
16. Gitlin D, Pericelli A, Gitlin GM. Synthesis of a α-fetoprotein by liver, yolk sac and gastrointestinal tract of the human conceptus. Cancer Res Rev. 1972; 32:979-982.
17. Giustozzi G, Gorazzi G, Bufalari A, et al. Hepatoid carcinoma of the stomach: is it still an unusual anatomo-clinical entity? Six case reports. J Exp Clin Cancer Rex. 1999;18:571-573.
18. Goodman ZD, Ishak KG, Langloss JM, et al. Combined hepatocellular-cholangiocarcinoma: a histologic and immunohistochemical study. Cancer. 1985;55:124-135.
19. Haratake J, Hashimoto H. An immunohistochemical analysis of 13 cases with combined hepatocellular and cholangiocellular carcinoma. Liver. 1995;15:9-15.
20. Hoshida Y, Nakakawa T, Mano S, et al. Hepatoid adenocarcinoma of the endometrium associated with alpha-fetoprotein production. Int J Gynecol Pathol. 1996;15:266-269.
21. Ishikura H, Fukasawa Y, Ogasawara K, et al. An AFP-producing gastric carcinoma with features of hepatic differentiation: a case repon. Cancer. 1985;56:840-848.
22. Ishikura H, Kirimoto K, Shamamoto M. Hepatoid adenocarcinoma of the stomach: an analysis of seven cases. Cancer. 1986;58:119-126.
23. Ishikura H, Kana M, Ito M, et al. Hepatoid adenocarcinoma: a distinctive histological subtype of alpha-fetoprotein-producing lung carcinoma. Virchows Arch A Pathol Anat. 1990;417:73-80.
24. Ishikura H, Ishiguro T, Enatsu C, et al. Hepatoid adenocarcinoma of the renal pelvis producing alpha-fetoprotein of hepatic type and bile pigment. Cancer. 1991;67:3051-3056.
25. Ishikura H, Kishimoto T, Andachi H, et al. Gastrointestinal hepatoid adenocarcinoma: venous permeation and mimicry of hepatocellular carcinoma, a report of four cases. Histopathology. 1997;31:47-54.
26. Kang GH, Kim YI. α-Fetoprotein-producing gastric carcinoma presenting focal hepatoid differentiation in metastatic lymph nodes. Virchows Arch. 1998;432:85-87.
27. Kodama T, Kameya T, Hirota T, et al. Production of alpha-fetoprotein, normal serum proteins and human chorionic gonadotropin in stomach cancer: histologic and immunohistochemical analyses of 35 cases. Cancer. 1981;48:1647-1655.
28. Kononen J, Bubendorf L, Kallioniemi A, et al. Tissue microarrays for high-throughout molecular profiling of tumor specimens. Nat Med. 1998;4:844-847.
29. Lattes C, Carella R, Faggioli S, et al. Hepatoid adenocarcinoma of the rectum arising in ulcerative colitis: report of a case. Dis Colon Rectum. 2000;43:105-108.
30. Leong AS-Y, Sormunen RT, Tsui WMS, et al. Hep Par 1 and selected antibodies in the immunohistochemical distinction of hepatocellular carcinoma from cholangiocarcinoma, combined tumours and metastatic carcinoma. Histopathology. 1998;33:318-324.
31. Maeda T, Adachi E, Kajiyama K, et al. Combined hepatocellular and cholangiocarcinoma: proposed criteria according to cytokeratin expression and analysis of clinicopathologic features. Hum Pathol. 1995;26:956-964.
32. Maeda T, Kajiyama K, Adachi E, et al. The expression of cytokeratins 7, 19, and 20 in primary and metastatic carcinomas of the liver. Mod Pathol. 1996;9:901-909.
33. Maitra A, Murakata LA, Albores-Saavedra J. Immunoreactivity for Hepatocyte Paraffin 1 antibody in hepatoid adenocarcinoma of the gastrointestinal tract. Am J Clin Pathol. 2001;115:689-694.
34. Minervini MI, Demetris JA, Lee RG, et al. Utilization of hepatocyte-specific antibody in the immunocytochemical evaluation of liver tumors. Mod Pathol. 1997;10:686-692.
35. Moran CA, Suster S. Hepatoid yolk sac tumors of the mediastinum: a clinicopathologic and immunohistochemical study of four cases. Am J Surg Pathol. 1997;21:1210-1214.
36. Morimoto H, Tanigawa N, Inoue H, et al. Alpha-fetoprotein-producing renal cell carcinoma. Cancer. 1988;61:84-88.
37. Morinaga S, Takahashi Y. Primary hepatocellular carcinoma and hepatoid adenocarcinoma of the stomach with liver metastasis: an unusual association. Jpn J Clin Oncol. 1996;26:258-263.
38. Motoyama T, Aizawa K, Fujiwara T, et al. Coexistence of choriocarcinoma and hepatoid adenocarcinoma in the stomach. Pathol Int. 1994;44:716-721.
39. Motoyama T, Aizawa K, Watanabe H, et al. α-Fetoprotein producing gastric carcinomas: a comparative study of three different subtypes. Acta Pathol Jpn. 1993;43:654-661.
40. Motoyama T, Higuchi M, Taguchi J. Combined choriocarcinoma, hepatoid adenocarcinoma, small cell carcinoma and tubular adenocarcinoma in the esophagus. Virchows Arch. 1995:427-454.
41. Okuda T, Peters RL, Simson IW. Gross anatomic of hepatocellular carcinoma from three disparate geographic areas: proposal of a new classification. Cancer. 1984;54:2165-2173.
42. Paner GP, Thompson KS, Reynes CV. Hepatoid carcinoma of the pancreas. Cancer. 2000;88:1582-1589.
43. Petrella T, Montagnon J, Roignot P, et al. Alphafetoprotein-producing gastric adenocarcinoma. Histopathology. 1995;26:171-175.
44. Pitman MB, Triratanachat S, Young RH, et al. Hepatocyte Paraffin 1 antibody cannot distinguish primary ovarian malignancies with hepatoid differentiation from metastatic hepatocellular carcinoma. Mod Pathol. 2002;15:206A.
45. Shintaku M, Kariya M, Shime H, et al. Adenocarcinoma of the uterine cervix with choriocarcinomatous and hepatoid differentiation: report of a case. Int J Gynecol Pathol. 2000;19:174-178.
46. Sinard J, Macleay L Jr, Melamed J. Hepatoid adenocarcinoma in the urinary bladder: unusual localization of a newly recognized tumor type. Cancer. 1994;73:1919-1925.
47. Tickoo SK, Zee SY, Obiekwe S, et al. Combined hepatocellular-cholangiocarcinoma: a histopathologic, immunohistochemical and in situ hybridization study. Am J Surg Pathol. 2002;26:999-997.
48. Tornillo L, Carafa V, Richter J, et al. Marked genetic similarities between hepatitis-B-virus positive and hepatitis-C-virus positive hepatocellular carcinomas. J Pathol. 2000;192:307-312.
49. Toyoda H, Hirai T, Ishii E. Alpha-fetoprotein producing uterine corpus carcinoma: a hepatoid adenocarcinoma of the endometrium. Pathol Int. 2000;50:847-852.
50. Tsuji M, Kashihara T, Terada N, et al. An immunohistochemical study of hepatic atypical adenomatous hyperplasia, hepatocellular carcinoma, and cholangiocarcinoma with α-fetoprotein, carcinoembryonic antigen, CA19-9, epithelial membrane antigen, and cytokeratins 18 and 19. Pathol Int. 1999;49:310-314.
51. Trevisani F, D'Intino PE, Caraceni P, et al. Etiologic factors and clinical presentation of hepatocellular carcinoma. Cancer. 1995;75:2220-2232.
52. Van Eyken P, Sciot R, Paterson A, et al. Cytokeratin expression in hepatocellular carcinoma: an immunohistochemical study. Hum Pathol. 1988;19:562-568.
53. Yano T, Ishikura H, Wada T, et al. Hepatoid adenocarcinoma of the pancreas. Histopathology. 1999;35:86-95.
54. Wennerberg AE, Nalesnik M, Coleman WB. Hepatocyte Paraffin 1: a monoclonal antibody that reacts with hepatocytes and can be used for differential diagnosis of hepatic tumors. Am J Pathol. 1993;143:1050-1054.
55. rd ed, vol II. Edinburgh: Churchill Livingstone, 1994:1-52.
56. Wong N, Lai P, Lee SW, et al. Assessment of genetic changes in hepatocellular carcinoma by comparative genomic hybridization analysis: relationship to disease stage, tumor size and cirrhosis. Am J Pathol. 1999;154:37-43.