The expression of cytokeratins 7, 19, and 20 in primary and metastatic carcinomas of the liver

Modern Pathology

Volumn 9, Issue 9, 1996, Pages 901-909

  Maeda, Takashi ^a   Kajiyama, Kiyoshi ^a   Adachi, Eisuke ^a   Takenaka, Kenji ^a   Sugimachi, Keizo ^a   Tsuneyoshi, Masazumi ^a  

^a KYUSHU UNIVERSITY   (Japan)

Author keywords

Cholangiocarcinoma; Cytokeratin; Differential diagnosis; Hepatocellular carcinoma; Metastatic carcinoma

Indexed keywords

ALPHA FETOPROTEIN; CARBOHYDRATE ANTIGEN; CARCINOEMBRYONIC ANTIGEN; CYTOKERATIN;

ARTICLE; BILE DUCT CARCINOMA; COLORECTAL CARCINOMA; CONTROLLED STUDY; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; LIVER CELL CARCINOMA; LIVER METASTASIS; MAJOR CLINICAL STUDY; PRIORITY JOURNAL;

ADENOCARCINOMA; BILE DUCT NEOPLASMS; BILE DUCTS, INTRAHEPATIC; CARCINOMA, HEPATOCELLULAR; CHOLANGIOCARCINOMA; COLORECTAL NEOPLASMS; DIAGNOSIS, DIFFERENTIAL; HUMANS; IMMUNOENZYME TECHNIQUES; INTERMEDIATE FILAMENT PROTEINS; KERATIN-20; KERATINS; LIVER NEOPLASMS; TUMOR MARKERS, BIOLOGICAL;

EID: 0029738819     PISSN: 08933952     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (30)

1. Fischer HP, Altmannsberger M, Weber K, Osborn M: Keratin polypeptides in malignant epithelial liver tumors: Differential diagnostic and histogenetic aspects. Am J Pathol 127:530, 1987
2. Balaton AJ, Nehama-Sibony M, Gotheil C, Callard P, Baviera EE: Distinction between hepatocellular carcinoma, cholangiocarcinoma, and metastatic carcinoma based on immunohistochemical staining for carcinoembryonic antigen and for cytokeratin 19 on paraffin sections. J Pathol 156:305, 1988
3. Christensen WN, Boitnott JK, Kuhajda FP: Immunoperoxidase staining as a diagnostic aid for hepatocellular carcinoma. Mod Pathol 2:8, 1989
4. Ma CK, Zarbo RJ, Frierson HF, Lee MW: Comparative immunohistochemical study of primary and metastatic carcinomas. Am J Clin Pathol 99:551, 1993
5. Johnson DE, Powers CN, Rupp G, Frable WJ: Immunocytochemical staining of fine-needle aspiration biopsies of the liver as a diagnostic tool for hepatocellular carcinoma. Mod Pathol 5:117, 1992
6. Hurlimann J, Gardiol D: Immunohistochemistry in the differential diagnosis of liver carcinomas. Am J Surg Pathol 15:280, 1991
7. Osborn M, van Lessen G, Weber K, Klöppel G, Altmannsberger M: Differential diagnosis of gastrointestinal carcinomas by using monoclonal antibodies specific for individual keratin polypeptides. Lab Invest 55:497, 1986
8. Johnson DE, Herndier BG, Medeiros LJ, Warnke RA, Rouse RV: The diagnostic utility of the keratin profiles of hepatocellular carcinoma and cholangiocarcinoma. Am J Surg Pathol 12:187, 1988
9. Van Eyken P, Sciot R, Paterson A, et al.: Cytokeratin expression in hepatocellular carcinoma: An immunohistochemical study. Hum Pathol 19:562, 1988
10. Maeda T, Adachi K, Kajiyama K, Sugimachi K, Tsuneyoshi M: Combined hepatocellular and cholangiocarcinoma: Proposed criteria according to cytokeratin expression and analysis of clinicopathologic features. Hum Pathol 26:956, 1995
11. Moll R, Franke WW, Schiller DL, Geiger B, Krepler R: The catalog of human cytokeratins: Pattern of expression in normal epithelia, tumors and cultured cells. Cell 31:11, 1982
12. Moll R, Löwe A, Laufer J, Franke WW: Cytokeratin 20 in human carcinomas: A new histodiagnostic marker detected by monoclonal antibodies. Am J Pathol 140:427, 1992
13. Zou-Rong Si, Itzkowitz SH, Kim YS: A comparison of three immunoperoxidase technique for antigen detection in colorectal carcinoma tissue. J Histochem Cytochem 36:317, 1988
14. Fucich LF, Cheles MK, Thung SN, Gerber MA, Marrogi AJ: Primary vs metastatic hepatic carcinoma: An immunohistochemical study of 34 cases. Arch Pathol Lab Med 118:927, 1994
15. Lee FY, Lee SD, Tsai YT, et al.: Serum C-reactive protein as a serum marker for the diagnosis of hepatocellular carcinoma. Cancer 63:1567, 1989
16. Ganjei P, Nadji M, Albores-Saavedra I, Morales AR: Histologic markers in primary and metastatic tumors of the liver. Cancer 62:1994, 1988
17. Jovanovic R, Jagirder I, Thung SN, Paronetto F: Blood group-related antigen Lewis x and Lewis y in the differential diagnosis of cholangiocarcinoma and hepatocellular carcinoma. Arch Pathol Lab Med 113:139, 1989
18. Roncalli M, Borzio M, De Diagi G, et al.: Liver cell dysplasia and hepatocellular carcinoma: A histological and immunohistochemical study. Histopathology 9:209, 1985
19. Brumm C, Schulze C, Charels K, Morohoshi T, Klöppel G: The significance of alpha-fetoprotein and other tumour markers in differential immunocytochemistry of primary liver tumours. Histopathology 14:503, 1989
20. Goodman ZD, Ishak KG, Langloss JM, Sesterhenn IA, Rabin L: Combined hepatocellular-cholangiocarcinoma. A histologie and immunohistochemical study. Cancer 55:124, 1985
21. Imoto M, Nishimura D, Fukuda Y, et al.: Immunohistochemical detection of alpha-fetoprotein, carcinoembryonic antigen, and ferritin in formalin-paraffin sections from hepatocellular carcinoma. Am J Gastroenterol 80:902, 1985
22. Ordonez NG, Manning JT Jr: Comparison of alpha-1-antitrypsin and alpha-1-antichymotrypsin in hepatocellular carcinoma: An immunoperoxidase study. Am J Gastroenterol 79:959, 1984
23. Ferrandez-Izquierdo A, Llombart-Bosch A: Immunohistochemical characterization of 130 cases of primary hepatic carcinomas. Pathol Res Pract 182:783, 1987
24. Bonetti F, Chilosi M, Pisa R, et al.: Epithelial membrane antigen expression in cholangiocarcinoma. A useful immunohistochemical tool for differential diagnosis with hepatocellular carcinoma. Virchows Arch A Pathol Anat Histopathol 401:307, 1983
25. Lazarides E: Intermediate filaments as mechanical integrators of cellular space. Nature 283:249, 1980
26. Sarbia M, Borchard F: Histogenetical investigations on adenocarcinomas of the esophagogastric junction. Pathol Res Pract 189:530, 1993
27. Ballestin C, Nevado M, Gil-Martin R, Sanz-Anquela M, Lopez JI: Expression of keratin 20 in malignant eccrine poromas. Path Res Pract 11:1994, 190
28. Miettinen M: Keratin 20: Immunohistochemical marker for gastrointestinal, urothelial, and Merkel cell carcinomas. Mod Pathol 8:384, 1995
29. Weinbren K, Mutum SS: Pathological aspects of cholangiocarcinoma. J Pathol 139:217, 1983
30. Nakajima T, Kondo Y, Miyazaki M, Okui K: A histopathologic study of 102 cases of intrahepatic cholangiocarcinoma: Histologie classification and modes of spreading. Hum Pathol 19:1228, 1988