Lansoprazole increases testosterone metabolism and clearance in male Sprague-Dawley rats: Implications for Leydig cell carcinogenesis

Toxicology and Applied Pharmacology

Volumn 192, Issue 2, 2003, Pages 154-163

  Coulson, Michelle ^a   Gibson, G Gordon ^a   Plant, Nick ^a   Hammond, Tim ^b   Graham, Mark ^b  

^a UNIVERSITY OF SURREY   (United Kingdom)

^b ASTRAZENECA   (United Kingdom)

Author keywords

Cytochrome P450; Hyperplasia; Induction; Lansoprazole; Leydig cell; Liver; Rat; Steroid hydroxylases; Testis; Testosterone metabolism; Tumours

Indexed keywords

CARBON 14; CYTOCHROME P450; FOLLITROPIN; LANSOPRAZOLE; LUTEINIZING HORMONE; PROLACTIN; TESTOSTERONE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; AREA UNDER THE CURVE; ARTICLE; CARCINOGENESIS; CONTROLLED STUDY; ENZYME INDUCTION; FOLLITROPIN BLOOD LEVEL; HOMEOSTASIS; HYPOTHALAMUS HYPOPHYSIS GONAD SYSTEM; ISOTOPE LABELING; LEYDIG CELL TUMOR; LIVER METABOLISM; LIVER MICROSOME; LIVER WEIGHT; LUTEINIZING HORMONE BLOOD LEVEL; NONHUMAN; PLASMA CLEARANCE; PROLACTIN BLOOD LEVEL; RAT; TESTOSTERONE BLOOD LEVEL; TESTOSTERONE METABOLISM;

RODENTIA;

EID: 0141794309     PISSN: 0041008X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0041-008X(03)00275-8     Document Type: Article

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