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Volumn 44, Issue 42, 2003, Pages 7731-7733

Synthesis of natural (-)-hamigeran B

Author keywords

Hamigeran B; Hydrogenolysis; Meyers' lactam; Silyl groups

Indexed keywords

ANTINEOPLASTIC AGENT; ANTIVIRUS AGENT; HAMIGERAN B; IODINE; LACTAM; LITHIUM DERIVATIVE; UNCLASSIFIED DRUG;

EID: 0141794065     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tetlet.2003.08.089     Document Type: Article
Times cited : (29)

References (26)
  • 2
    • 85031051540 scopus 로고    scopus 로고
    • note
    • Details of the biological tests have not been published; the antiviral activity is described as follows: Hamigeran B.showed 100% virus inhibition against both the Herpes and Polio viruses, with only slight cytotoxicity throughout the whole well at a concentration of 132 μg per disk.
  • 5
    • 85031058783 scopus 로고    scopus 로고
    • note
    • 3) (personal communication from Professor K. C. Nicolaou).
  • 15
    • 85031056303 scopus 로고    scopus 로고
    • note
    • Made from 2,5-dimethylphenol by the method of Ref. 14, except that the formyl group was best generated by benzylic bromination (Ref. 15), followed by oxidation with DMSO (Ref. 16).
  • 21
    • 85031056503 scopus 로고    scopus 로고
    • note
    • 2 groups of the ethyl substituent.
  • 22
    • 85031066116 scopus 로고    scopus 로고
    • Chiralcel OD column (0.46×5 cm); eluant 4:1 i-PrOH-hexane; flow rate 1.0 mL/min; detection at 230 nm, temperature 25°C; sample concentration ca. 1 mL/mg in MeOH, injection volume 20 μL.
    • Chiralcel OD column (0.46×5 cm); eluant 4:1 i-PrOH-hexane; flow rate 1.0 mL/min; detection at 230 nm, temperature 25°C; sample concentration ca. 1 mL/mg in MeOH, injection volume 20 μL.
  • 26
    • 85031063454 scopus 로고    scopus 로고
    • note
    • 2 284.17764, found 284.17735.


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.