Stereospecific total synthesis of the antiviral agent hamigeran B - Use of large silyl groups to enforce facial selectivity and to suppress hydrogenolysis

Angewandte Chemie - International Edition

Volumn 42, Issue 29, 2003, Pages 3406-3409

  Clive, Derrick L J ^a   Wang, Jian ^a  

^a UNIVERSITY OF ALBERTA   (Canada)

Author keywords

Hamigeran B; Hydrogenolysis; Natural products; Silyl groups; Total synthesis

Indexed keywords

CHEMICAL BONDS; HYDROGENATION; STEREOCHEMISTRY; VIRUSES;

ANTIVIRAL AGENTS;

KETONES;

ANTIVIRUS AGENT; HAMIGERAN B; NATURAL PRODUCT; SILOXANE; UNCLASSIFIED DRUG;

ANTIVIRAL ACTIVITY; ARTICLE; CHEMICAL REACTION; COVALENT BOND; CYCLIZATION; DRUG STRUCTURE; DRUG SYNTHESIS; HERPES VIRUS; HYDROGENATION; HYDROGENOLYSIS; POLIOMYELITIS VIRUS; REACTION ANALYSIS; STEREOSPECIFICITY; STRUCTURE ANALYSIS;

ANTIVIRAL AGENTS; CRYSTALLOGRAPHY, X-RAY; HYDROGENATION; MODELS, CHEMICAL; MOLECULAR STRUCTURE; NAPHTHOQUINONES; SILICON; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0042530467     PISSN: 14337851     EISSN: None     Source Type: Journal    
DOI: 10.1002/anie.200351519     Document Type: Article

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