Hemorrhagic syndrome induced by caterpillars. Clinical and experimental studies. Review;Síndrome hemorrágico producido por contacto con orugas. Estudios clínicos y experimentales. Revisión

Investigacion Clinica

Volumn 44, Issue 2, 2003, Pages 155-163

  Arocha Piñango, Carmen Luisa ^a   Guerrero, Belsy ^a  

^a INSTITUTO VENEZOLANO DE INVESTIGACIONES CIENTÍFICAS   (Venezuela)

Author keywords

Bleeding syndroms; Hemostatic alteration; Lonomia achelous

Indexed keywords

ANTIFIBRINOLYTIC AGENT; BLOOD CLOTTING FACTOR 13; BLOOD CLOTTING FACTOR 5; BLOOD CLOTTING FACTOR 8; FIBRINOGEN; FRESH FROZEN PLASMA; VON WILLEBRAND FACTOR; ARTHROPOD VENOM;

BLEEDING DISORDER; BLOOD CLOTTING TEST; CATERPILLAR; CLINICAL FEATURE; CRYOPRECIPITATE; GASTROINTESTINAL DISEASE; HEMATOMA; HEMATURIA; HEMOPERITONEUM; HUMAN; INSECT; KIDNEY FAILURE; LUNG HEMORRHAGE; NONHUMAN; PARTIAL THROMBOPLASTIN TIME; PROTHROMBIN TIME; REVIEW; THROMBIN TIME; THROMBOCYTE COUNT; ANIMAL; BLEEDING; BLOOD; BLOOD CLOTTING; CHEMISTRY; DISSEMINATED INTRAVASCULAR CLOTTING; DRUG ANTAGONISM; DRUG EFFECT; FIBRINOLYSIS; LEPIDOPTERA; PHYSIOLOGY; SYNDROME;

ANIMALS; ANTIFIBRINOLYTIC AGENTS; ARTHROPOD VENOMS; BLOOD COAGULATION; DISSEMINATED INTRAVASCULAR COAGULATION; FACTOR XIII; FIBRINOLYSIS; HEMORRHAGE; HUMANS; LEPIDOPTERA; SYNDROME;

EID: 0141789759     PISSN: 05355133     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (39)

1. Arocha-Piñango CL. Fibrinólisis producida por contacto con orugas. Acta Cient Ven 1967; 18:136-139.
2. Lemaire C. Revision du genre Lonomia Walker (Lep attacidae). Ann Soc Ent Fr 1972; 8:767-861.
3. Arocha-Piñango CL, Blumenfeld-Bosch N, Nouel AL, Torres A, Perales J, Alonso ME, Rodríguez S, Carvajal Z, Ojeda A, Tasayco ML, Chitty W. Fibrinolytic and procoagulant agents from a saturnidae moth caterpillar In: Pirkle H. and Markland FS, (eds). Hemostasis and animal venoms. Marcel Dekker Inc. Pub. New York 1988; pp 223-240.
4. Arocha-Piñango CL, Blumenfeld-Bosch N, Torres A, Goldstein C, Nouel A, Arguello A, Carvajal Z, Guerrero B, Ojeda A, Rodríguez A. Six new cases of caterpillar bleeding syndrome. Thromb Haemostas 1992; 67:402-407.
5. Arocha-Piñango CL, Bosch BN, Torres A, Nouel A, Caldera H, Pabón R, Carvajal Z, Rodríguez S, Ojeda A, Rodríguez A, Arguello A, Chacín A, Pabón N. Sindrome hemorragico producido por orugas de la región amazónica. Estudio Clinico y Biologico. IX Congreso Latinoamericano de Hemostasia y Trombosis. 1985. Rio de Janeiro, Brasil, p34.
6. Vasquez A, Bastardo A, Zavala J, Ramirez N, Yepez N, Uriepero Y, Martinez M, Nouel A. Enfermedad hemorragica producida por contacto con orugas de la especia Lonomia achelous. A propósito de un caso clínico. Resúmenes del V Congreso Venezolano de Hepatología; 1997, Pro. Ordaz, Venezuela. p 93.
7. García J, Rendon C, Brewster F, Guipc S, Gonzalez A, Nazzoure J, Flores L, Frontado C, Guillen A, Tilac C, Pernalete N. Acute renal insuficiency due to Lonomia achelous envenomentions. Abstracts of the 2nd Latin American Congress on Acute Renal Failure. 2000. Rio de Janeiro, Brasil, p 20.
8. Fraiha-Neto H, Costa D, Quiroz de Leao RN, Ballarini AJ. Acidentes hemorrágicos por larvas de Lonomia. In: S. Schvartsman, Plantas venenosas e animais peçohentos. (ed), Sarvier Pub. Sao Paulo Brazil. 1992; pp 241-244.
9. Hommel D, Bouchareine L, Hulin A. Envenimation par une chenille de lépidoptèra-Lonomia achelous Revue de la littérature. Á propos de deux cas en Guyane Française. Sem Hop Paris. 1995; 71:9-12.
10. Couppie P, Marty C, Sainte-Marie D, Pradinaud R. Poisonous caterpillars in French Guyana. 5 cases. Ann Dermatol Venereol 1998, 125(8):489-491.
11. Kelen EMA, Picarelli ZP, Duarte AC. Hemorrhagic syndrome induced by contact with caterpillars of the genus Lonomia (Saturnidae, Hemileucinae). J Toxicol Rev 1995; 14:283-308.
12. Duarte AC, Crusius PS, Pires CA, Schilling MA, Fan H.W. Intracerebral haemorrhage after contact with Lonomia caterpillars. Lancet 1996, 12; 348(9033):1033.
13. Duarte CA, Caovilla J, Lorini I, Lorini D, Mantorani G, Sumida J, Manfre PC, Silveira R, Moura SP. Insuficiencia renal aguda por acidentes com lagartas. J Bras Nefrol 1990; 12:184-187.
14. Burdmann EA, Antunes I, Saldanha LB, Abdulkader RC. Severe acute renal failure induced by the venom of Lonomia caterpillars. Clin Nephrol 1996; 46:337-339.
15. Dias Da Silva W, Rocha-Campos ACM, Gonçalves LRC, Sousa e Silva MCC, Higashi HG, Yamagushi IK, Kelen EMA. Development of an antivenom against toxins of Lonomia obliqua caterpillars. Toxicon 1996; 34:1045-1049.
16. Duarte AC, Coavilla JJ, Kelen EMA, Wen FH, Machado SMS, Herrman F, Renner LO, Santos SR, Tefilli AP, Rodriguez C, Butzke LMW. Estudo comparativo entre o soro anti-lonomico c o acido aminocaproico. 2° Encontro Nacional de acidentes com animais peçonhentos. 1997.Porto Alegre, Brasil. p 65.
17. Rocha-Campos AC, Goncalves LR, Higashi HG, Yamagushi IK, Fernandes I, Oliveira JE, Ribela MT, Sousa E-Silva MC, da Silva WD. Specific heterologous F(ab')2 antibodies revert blood incoagulability resulting from envenoming by Lonomia obliqua caterpillars. Am J Trop Med Hyg 2001, 64:283-289.
18. Arocha-Piñango CL, Marsh NA, Robinson D. A proteolytic substances from a saturnidae moth caterpillar. Partial isolation and purification. Thromb Diat Haem. 1973; 29:135-142.
19. Amarant T, Burkhart W, Levine H, Arocha-Piñango CL, Parikh I. Isolation and complete amino acid sequence of two fibrinolytic proteinases from the toxic Saturnid Caterpillar Lonomia achelous. Biochem Biophys Acta 1991; 1079:214-221.
20. Arocha-Piñango CL, Perales J, Carvajal Z. Studies on the degradation of fibrinogen by proteolytic enzymes from the larvae of Lonomia achelous (Cramer). Thromb Haemostas 1981; 45:233-236.
21. Coll-Sangrona E, Arocha-Piñango CL. Fibrinolytic action of whole body extracts and two semipurified fraction from Lonomia achelous, caterpillars studied by blood clot lysis. Brazilian J Med Biol Res 1998; 31:779-784.
22. López M, Arocha-Piñango C.L. The action of Lonomia achelous caterpillars venom on human Factor V. Thromb Res 2000, 98, 103-110.
23. Arocha-Piñango CL, Pepper DS. Studies of a fibrinolytic enzyme from the larvae of Lonomia achelous (Cramer) using chromogenic peptide substrates. Thromb Haemostas 1981; 46:710-713.
24. Guerrero B, Arocha-Piñango CL. Activation of human prothrombin by the venom of Lonomia achelous (Cramer) caterpillars. Thromb Res 1992; 66:169-178.
25. Guerrero B, Arocha-Piñango CL, Gil-San Juan A. Lonomia achelous caterpillar venom (LACV) selectively inactivate blood clotting Factor XIII. Thromb Res 1997; 87:83-93.
26. Guerrero B, Gil San Juan A, Perales J, Arocha-Piñango C.L. Effect on platelet FXIII and partial characterization of Lonomin V, a proteolytic enzyme from Lonomia achelous caterpillars. Thromb Res 1999; 93:243-252.
27. Guerrero B, Arocha-Piñango CL, Gil San Juan A. Degradation of human Factor XIII by Lonomin V, a purified fraction of Lonomia achelous caterpillar venom. Thromb Res 1997; 87:171-181.
28. Rocha-Campos ACM, Alves EW, Melo PD, Machado OLT, Diaz da Silva W. Lonomiatoxin: a 20 Kd protein present in bristles extracts of Lonomia obliqua extracts. Abstracts of 12th World Congress of the Intern Soc Toxin. Cuernavaca, México. 1997; Abstract P-033 Mo.
29. Donato JL, Moreno RA, Hyslop S, Duarte A, Antunes E, LeBonniec BF, Rendu F. de Nucci G. Lonomia obliqua caterpillar spicules trigger human blood coagulation via activation of Factor X and prothrombin. Thromb Haemostas 1998; 79:539-542.
30. Reis CV, Kelen EMA, Parasky SHP, Portaro FCV, Sampaio CAM, Fernandez BL, Camargo ACM, Chudzinski-Tavassi AM. A Ca++ activated serin protease (LOPAP) could be responsible for the haemorrhagic syndrome caused by the caterpillar Lonomia obliqua. Lancet 1995; 353, 1942.
31. Reis CV, Portaro FCV, Andrade SA, Oliva MLV, Fritzen M, Sampaio CAM, Camargo ACM, Chudzinski-Tavassi AM. A prothrombin activator serine protease from the Lonomia obliqua caterpillars venom (LOPAP): biochemical characterization. Thromb Res 2001; 102:427-436.
32. st. International Conference: Exogenous factor affecting thrombosis and haemostasis. 2001. Institut Pasteur, Paris. p 35.
33. Chudzinski-Tavassi AM, Schattner M, Fritzen M, Pozner RG, Reis CV, Lourenco M, Lazzari MA. Effects of LOPAP on human endothelial cells and platelets. Haemostasis 2001; 31:257-265.
34. Marval E, Guerrero B, Arocha-Piñango CL. The action of Lonomia achelous caterpillar venom on some blood coagulation and fibrinolysis parameters of the rabbit. Toxicon 1999; 37:1491-1504.
35. Guerrero B, Alves-Pinto M, Müller CA, Perales J, Gil A, Arocha-Piñango CL. Evaluation of dose and administration scheme of Lonomin V as thrombolytic agent in a rabbit jugular vein thromsosis model. Abstracts of the 20th Blankenese Conference Animal venoms: from neurotoxins to clotting factor. 2000. Hamburg-Blankenese, p 37.
36. Guerrero B, Alver Pinto M, Arocha-Piñango CL, Müller CA, Gil San Juan, A, Chermont A, Perales J. Thrombolytic and systemic effects of Lonomin V, a protein isolated from Lonomia achelous caterpillar, in rabbits. Blood Coag & Fibrinolysis 2001; 12:1-9.
37. Guerrero B, Perales J, Alves Pinto M, Müller CA, Gil San-Juan A, Amorin S, Arocha-Piñango CL. Enhancement of thrombolysis and inhibition of thrombus growth by Lonomin V. Abstracts of the XVIII Congress of the International Society on Thrombosis and Haemostasis, Paris, France, 2001, p 1298.
38. Reis CV, Farsky SHP, Fernandes BL, Santoro ML, Oliva MLV, Mariano M, Chudzinski-Tavassi. "In vivo" caracterization of Lopap, a prothrombin activator serine protease from the Lonomia obliqua caterpillar venom. Thromb Res 2001; 102:437-443.
39. Kawamoto F, Kumada N. Kininogenase activity and kinin-like substance in the venomous spicules and spines of lepidopteran larvac, Adv Exp Biol Med 1979; 120:51-55.