Elucidating the pathogenesis of schizophrenia

British Medical Journal

Volumn 327, Issue 7416, 2003, Pages 632-633

  Sawa, Akira ^a   Kamiya, Atsushi ^a  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BRAIN PROTEIN; DISRUPTED IN SCHIZOPHRENIA PROTEIN; GENE PRODUCT; MICROTUBULE ASSOCIATED PROTEIN 2; NEUROMODULIN; POSTSYNAPTIC DENSITY PROTEIN 95; PROTEIN; REELIN; UNCLASSIFIED DRUG;

AGYRIA; BEHAVIOR DISORDER; BRAIN CORTEX; BRAIN DEVELOPMENT; CARBOXY TERMINAL SEQUENCE; CELL PROLIFERATION; CHROMOSOME TRANSLOCATION; CYTOARCHITECTURE; EDITORIAL; FAMILIAL DISEASE; GENE EXPRESSION; GENE LOCATION; GENE LOCUS; GENETIC CODE; GENETIC PREDISPOSITION; GLIA CELL; HEREDITY; HUMAN; LINKAGE ANALYSIS; NERVE CELL DIFFERENTIATION; NERVE DEGENERATION; NEUROPATHOLOGY; NUCLEAR MAGNETIC RESONANCE IMAGING; OPEN READING FRAME; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN LOCALIZATION; REDUCTION; SCHIZOPHRENIA; SINGLE NUCLEOTIDE POLYMORPHISM;

EID: 0141789635     PISSN: 09598146     EISSN: None     Source Type: Journal    
DOI: 10.1136/bmj.327.7416.632     Document Type: Editorial

References (12)

1. Sawa A, Snyder SH. Schizophrenia: diverse approaches to a complex disease. Science 2002;296:692-5.
2. Berrettini WH. Are schizophrenic and bipolar disorders related? A review of family and molecular studies. Biol Psychiatry 2000;48:531-8.
3. Karayiorgou M, Gogos JA. A turning point in schizophrenia genetics. Neuron 1997:967-79.
4. Karlsson H, Bachmann S, Schroder J, McArthur J, Torrey EF, Yolken RH. Retroviral RNA identified in the cerebrospinal fluids and brains of individuals with schizophrenia. Proc Natl Acad Sci USA 2001;98:4634-9.
5. Harrison PJ. The neuropathology of schizophrenia. A critical review of the data and their interpretation. Brain 1999;122:593-624.
6. Weinberger DR. Implications of normal brain development for the pathogenesis of schizophrenia. Arch Gen Psychiatry 1987;44:660-9.
7. Weinberger DR, Torrey EF, Neophytides AN, Wyatt RJ. Lateral cerebral ventricular enlargement in chronic schizophrenia. Arch Gen Psychiatry 1979;36:735-9.
8. Millar JK, Wilson-Annan JC, Anderson S, Christie S, Taylor MS, Semple CA, et al. Disruption of two novel genes by a translocation co-segregating with schizophrenia. Hum Mol Genet 2000;9:1415-23.
9. Ekelund J, Hovatta I, Parker A, Paunio T, Varilo T, Martin R, et al. Chromosome 1 loci in Finnish schizophrenia families. Hum Mol Genet 2001;10:1611-7.
10. Ozeki Y, Tomoda T, Kleiderlein J, Kamiya A, Bord L, Fujii K et al. Disrupted-in-Schizophrenia-1 (DISC-1): mutant truncation prevents binding to NudE-like (NUDEL) and inhibits neurite outgrowth. Proc Natl Acad Sci USA 2003;100:289-94.
11. Dawson TM, Dawson VL. Rare genetic mutations shed light on the pathogenesis of Parkinson's disease. J Clin Invest 2003;111:145-51.
12. Harrison PJ, Owen MJ. Gene for schizophrenia? Recent findings and their pathophysiological implications. Lancet 2003;361:417-9.