Neonates with symptomatic hyperinsulinemic hypoglycemia generate inappropriately low serum cortisol counterregulatory hormonal responses

Journal of Clinical Endocrinology and Metabolism

Volumn 88, Issue 9, 2003, Pages 4342-4347

  Hussain, K ^a   Hindmarsh, P ^b   Aynsley Green, A ^b  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

CORTICOTROPIN; GLUCOSE; GROWTH HORMONE; HYDROCORTISONE; TETRACOSACTIDE;

ARTICLE; BOLUS INJECTION; CLINICAL ARTICLE; CLINICAL FEATURE; CONTROLLED STUDY; CORTICOTROPIN BLOOD LEVEL; DIAGNOSTIC PROCEDURE; DIET RESTRICTION; DOSE RESPONSE; FEMALE; HORMONE DETERMINATION; HORMONE RESPONSE; HUMAN; HYDROCORTISONE BLOOD LEVEL; HYPERINSULINISM; HYPOGLYCEMIA; MALE; NEWBORN; PRIORITY JOURNAL; REGULATORY MECHANISM; STATISTICAL SIGNIFICANCE;

ADRENOCORTICOTROPIC HORMONE; BLOOD GLUCOSE; FATTY ACIDS, NONESTERIFIED; HUMAN GROWTH HORMONE; HUMANS; HYDROCORTISONE; HYPERINSULINISM; HYPOGLYCEMIA; HYPOTHALAMIC AREA, LATERAL; INFANT, NEWBORN; INSULIN;

EID: 0141787940     PISSN: 0021972X     EISSN: None     Source Type: Journal    
DOI: 10.1210/jc.2003-030135     Document Type: Article

References (28)

1. Schwartz NS, Clutter WE, Shah SD, Cryer PE 1987 Glycaemic thresholds for the activation of glucose counter-regulatory systems are higher than the threshold for symptoms. J Clin Invest 79:777-780
2. De Feo P, Perriello G, Torlone E, Ventura MM, Fanelli C, Santeusanio F, Brunetti P, Gerich JE, Bolli GB 1989 Contribution of cortisol to glucose counter-regulation in man. Am J Physiol 257:E35-E42
3. Stevens JF 1970 Plasma cortisol levels in the neonatal period. Arch Dis Child 45:592-592
4. Weiner DJ, Smith J, Dahlan S, Berg G, Moshang T 1987 Serum adrenal steroid levels in healthy full-term 3 day old infants. J Pediatr 110:122-124
5. Vermes I, Dohanics J, Toth G, Pongracz J 1980 Maturation of the circadian rhythm of the adrenocortical functions in human neonates and infants. Horm Res 12:237-244
6. Anand KJS, Yacoub MH, Brown MJ, Sippell WG, Aynsley-Green A 1985 Endocrine and metabolic regulation in term neonates undergoing cardiac surgery with cardiopulmonary bypass. Pediatr Res 19:628
7. Hughes D, Murphy JF, Dyas J, Robinson JA, Riad-Fahmy D, Hughes IA 1987 Blood spot glucocor ticoid concentrations in ill preterm infants. Arch Dis Child 62:1014-1018
8. Mantagos S, Koulouris A, Vagenakis A 1991 A simple stress test for the evaluation of hypothalamic-pituitary-adrenal axis during the first 6 months of life. J Clin Endocrinol Metab 72:214-216
9. Hughes IA 1986 Handbook of endocrine tests in children. Bristol: Wright; 138-139
10. Savage DCL, Swift PGF, Johnstone PGB, Goldie DJ, Murphy D 1978 Combined test of anterior pituitary function in children. Arch Dis Child 53:301-304
11. Erturk E, Jaffe CA, Barkan AL 1998 Evaluation of the integrity of the hypothalamic-pituitary-adrenal axis by insulin hypoglycemia test. J Clin Endocrinol Metab 83:2350-2354
12. Fish HR, Chernow B, O'Brian JT 1986 Endocrine and neurophysiologic responses of the pituitary to insulin-induced hypoglycemia: Metabolism 35:763-780
13. Hussain K, Aynsley-Green A 2000 Management of hyperinsulinism in infancy and childhood. Ann Med 32:544-551
14. Glaser B, Thornton P, Otonkoski T, Junien C 2000 Genetics of neonatal hyperinsulinism [Review]. Arch Dis Child Fetal Neonatal Ed 82:F79-F86
15. Dunne MJ, Cosgrove KE, Shepherd RM, Ammala C 1999 Potassium channels, sulphonylurea receptors and control of insulin release. Trends Endocrinol Metab 10:146-152
16. Morris AAM, Thekekara A, Wilks Z, Clayton P, Leonard JVL, Aynsley-Green A 1996 Evaluation of fasts for investigating hypoglycaemia or suspected metabolic disease. Arch Dis Child 75:115-119
17. Dattani M 2002 Tests in paediatric endocrinology and normal values. In: Brook CGD, Hindmarsh PC, eds. Clinical paediatric endocrinology, 4th Ed. London: Blackwell Science; 468
18. Aynsley-Green A, Hussain K, Hall J, Saudubray JM, Nihoul-Fé kété C, De Lonlay-Debeney P, Brunelle F, Otonkoski T, Thornton P, Lindley JK 2000 The practical management of hyperinsulinism in infancy. Arch Dis Child Fetal Neonatal Ed 82:F98-F107
19. Davis MR, Shamoon H 1991 Counter-regulatory adaptation to recurrent hypoglycaemia in normal humans. J Clin Endocrinol Metab 73:995-1000
20. Widom B, Simonson DC 1992 Intermittent hypoglycaemia impairs glucose counter-regulation. Diabetes 41:1597-1602
21. McCall SL, Fixman LB, Tornheim K, Chich W, Ruderman NB 1986 Chronic hypoglycaemia increases brain glucose transport. Am J Physiol 251:E442-E447
22. Baskin DG, Figlewicz DP, Woods SC, Porte Jr D, Dorsa DM 1987 Insulin in the brain [Review]. Annu Rev Physiol 49:335-347
23. Corp ES, Woods SC, Porte D, Dorsa DM, Figlewicz DP, Baskin DG 1986 Localisation of insulin binding sites in the rat hypothalamus by quantitative autoradiography. Neurosci Lett 79:17-22
24. Havrankova J, Roth J, Brownstein MJ 1983 Insulin receptors in brain. Adv Metab Disord 10:259-268
25. Plagemann A, Harder T, Rake A, Voits M, Fink H, Rohde W, Dorner G 1999 Perinatal elevation of hypothalamic insulin, acquired malformation of hypothalamic galaninergic neurons, and syndrome x-like alterations in adulthood of neonatally overfed rats. Brain Res 836:146-155
26. Davis MR, Shamoon H 1991 Deficient counter-regulatory hormone responses during hypoglycaemia in a patient with insulinoma. J Clin Endocrinol Metab 72:788-792
27. + channels. Pflugers Arch 415:479-483
28. Inagaki N, Tsuura Y, Namba N, Masuda K, Gonoi T, Horie M, Mizuta M, Seino S 1995b Cloning and functional characterization of a novel ATP-sensitive potassium channel ubiquitously expressed in rat tissues including pancreatic islets, pituitary, skeletal muscle and heart. J Biol Chem 270:5691-5694