Selective metalation of 6-methylpurines: Synthesis of 6-fluoromethylpurines and related nucleosides

Nucleosides, Nucleotides and Nucleic Acids

Volumn 22, Issue 5-8, 2003, Pages 747-749

  Hassan, Abdalla E A ^a,b   Parker, William B ^a   Allan, Paula W ^a   Montgomery, John A ^a   Secrist III, John A ^a  

^a SOUTHERN RESEARCH INSTITUTE   (United States)

^b PHARMASSET INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

6 FLUOROMETHYLPURINE DERIVATIVE; 6 METHYLPURINE; LITHIUM ION; NUCLEOSIDE; POTASSIUM; PRODRUG; PURINE DERIVATIVE; RIBOSIDE DERIVATIVE; SODIUM; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; CANCER THERAPY; CHEMICAL REACTION; CONFERENCE PAPER; CONTROLLED STUDY; CYTOTOXICITY; DRUG SYNTHESIS; GENE THERAPY; HUMAN; HUMAN CELL; SUICIDE GENE;

GENE THERAPY; INDICATORS AND REAGENTS; METALS; METHYLATION; PURINE NUCLEOSIDES; PURINES;

EID: 0141760388     PISSN: 15257770     EISSN: None     Source Type: Journal    
DOI: 10.1081/NCN-120022625     Document Type: Conference Paper

References (5)

1. a) Sorscher, E.J.; Peng, S.; Bebok, Z.; Allan, P.W.; Bennett, L.L., Jr.; Parker, W.B. Gene Therapy 1994, 1, 233-238;
2. b) Parker, W.B.; King, S.A.; Allan, P.W.; Bennett, L.L., Jr.; Secrist III, J.A.; Montgomery, J.A.; Gilbert, K.S.; Waud, W.R.; Wells, A.H.; Gillespie, G.Y.; Sorscher, E.J. Human Gene Therapy, 1997, 8, 1637-1644;
3. c) Hughes, B.W.; King, S.A.; Allan, P.W.; Parker, W.B.; Sorscher, E.J. J. Biol. Chem. 1998, 273, 2322-2328;
4. d) Hassan, A.E.A.; Abou-Elkhair, R.A.I.; Montgomery, J.A.; Secrist III, J.A. Nucleosides, Nucleotides & Nucleic Acids 2000, 19 (7), 1123-1134.
5. Komamoto, H.; Tanaka, H.; Takioka, R.; Ishida, Y.; Nakamura, A.; Kimura, S.; Hayakawa, H.; Kato, K.; Miyasaka, T. J. Org. Chem. 1999, 64, 7773-7780.