High antithrombin III levels attenuate hemostatic activation and leukocyte activation during cardiopulmonary bypass

Journal of Thoracic and Cardiovascular Surgery

Volumn 126, Issue 3, 2003, Pages 906-907

  Koster, Andreas ^a   Chew, Derek ^b   Kuebler, Wolfgang ^c   Habazettl, Helmut ^c   Hetzer, Roland ^a   Kuppe, Herman ^a  

^a DEUTSCHES HERZZENTRUM BERLIN   (Germany)

^b FLINDERS MEDICAL CENTRE   (Australia)

^c FREIE UNIVERSITÄT BERLIN   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ANTITHROMBIN III; BIOCHEMICAL MARKER; HEPARIN;

ADULT; AGED; ARTICLE; BLEEDING; BLOOD CLOTTING; BLOOD TRANSFUSION; CARDIOPULMONARY BYPASS; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DRUG MEGADOSE; FEMALE; HEMOSTASIS; HEPARINIZATION; HUMAN; LEUKOCYTE ACTIVATION; MAJOR CLINICAL STUDY; MALE; PREOPERATIVE PERIOD; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; REPERFUSION INJURY;

EID: 0141742151     PISSN: 00225223     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0022-5223(03)00392-1     Document Type: Article

References (5)

1. Woodman RC, Ostrovsky L, Teoh D, Payne D, Poon M, Kubes P. Antithrombin and ischemia/reperfusion. Blood Coagtil Fibrinolysis. 1998;9(Suppl 2):S7-15.
2. Despotis GJ, Joist HJ, Hogue CW Jr, Alsoufiev A, Joiner-Maier D, Santoro SA, et al. More effective suppression of hemostatic system activation in patients undergoing surgery by heparin dosing based on heparin blood concentrations rather than ACT. Thromb Haemost. 1996; 76:902-8.
3. Despotis GJ, Joist JH, Hogue CW Jr, Alsoufiev A, Kater K, Goodnough LT, et al. The impact of heparin concentration and activated clotting time monitoring on blood conservation. A prospective randomized evaluation in patients undergoing cardiac operation. J Thorac Cardiovasc Surg. 1996;111:493-54.
4. Raymond PD, Marsh NA. Alterations to haemostasis following cardiopulmonary bypass and the relationship of these changes to neurocognitive morbidity. Blood Coagul Fibrinolysis. 2001;12:601-18.
5. Hansen PR. Role of neutrophils in myocardial ischemia and reperfusion. Circulation. 1995;91:1872-85.