Solution-phase parallel synthesis of substituted 1,2-ethyl and 1,3-propyl diamines

Tetrahedron Letters

Volumn 44, Issue 41, 2003, Pages 7575-7577

  Dagan, Ido D ^a   Lowden, Christopher T ^a  

^a Pharmaceutical Product Development   (United States)

Author keywords

1,2 ethyldiamines; 1,3 propyldiamines; Solution phase parallel synthesis

Indexed keywords

DIAMINE DERIVATIVE;

ARTICLE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; PROTON NUCLEAR MAGNETIC RESONANCE; PURIFICATION; SYNTHESIS;

EID: 0141741290     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tetlet.2003.08.067     Document Type: Article

References (10)

1. For recent reviews on solution-phase parallel synthesis, see: (a) Hall, D. G.; Manku, S.; Wang, F. J. Comb. Chem. 2001, 3, 125-150; (b)Thomson, L. A. Curr. Opin. Chem. Biol. 2000, 4, 324-337; (c) Sun, C. M. Comb. Chem. High Throughput Screen. 1999, 6, 299-318; (d) Wentworth, P. Trends Biotechnol. 1999, 17, 448-452.
2. For recent reviews on solution-phase parallel synthesis, see: (a) Hall, D. G.; Manku, S.; Wang, F. J. Comb. Chem. 2001, 3, 125-150; (b)Thomson, L. A. Curr. Opin. Chem. Biol. 2000, 4, 324-337; (c) Sun, C. M. Comb. Chem. High Throughput Screen. 1999, 6, 299-318; (d) Wentworth, P. Trends Biotechnol. 1999, 17, 448-452.
3. For recent reviews on solution-phase parallel synthesis, see: (a) Hall, D. G.; Manku, S.; Wang, F. J. Comb. Chem. 2001, 3, 125-150; (b)Thomson, L. A. Curr. Opin. Chem. Biol. 2000, 4, 324-337; (c) Sun, C. M. Comb. Chem. High Throughput Screen. 1999, 6, 299-318; (d) Wentworth, P. Trends Biotechnol. 1999, 17, 448-452.
4. For recent reviews on solution-phase parallel synthesis, see: (a) Hall, D. G.; Manku, S.; Wang, F. J. Comb. Chem. 2001, 3, 125-150; (b)Thomson, L. A. Curr. Opin. Chem. Biol. 2000, 4, 324-337; (c) Sun, C. M. Comb. Chem. High Throughput Screen. 1999, 6, 299-318; (d) Wentworth, P. Trends Biotechnol. 1999, 17, 448-452.
5. Badolo L., Hanocq M., Dubois J. Cell Biol. Toxicol. 14:1998;419-428.
6. DeCosta B.R., Radesca L., DiPaolo L., Bowen W.D. J. Med. Chem. 35:1992;38-47.
7. Choi S.-W., Elmaleh D.R., Hanson R.N., Fischman A.J. J. Med. Chem. 42:1999;3647-3656.
8. Sawanishi H., Wakusawa S., Murakami R., Miyamoto K., Tanaka K., Yoshifuji S. Chem. Pharm. Bull. 42:1994;1459-1462.
9. A 96-position microtiter plate formatted aluminum heating block obtained from Kontes was loaded with 1 mL glass vials from Wheaton.
10. 3) δ 7.62 (1H, d, J=8.3 Hz), 7.36 (1H, d, J=2.3 Hz), 7.27-7.23 (2H, m), 6.95-6.92 (2H, m), 3.90 (2H, s), 3.79 (2H, s), 3.54 (2H, t, J=6.8 Hz), 2.90 (2H, t, J=7.3 Hz).