Testosterone inhibits the prostaglandin F2α-mediated increase in intracellular calcium in A7r5 aortic smooth muscle cells: Evidence of an antagonistic action upon store-operated calcium channels

Journal of Endocrinology

Volumn 178, Issue 3, 2003, Pages 381-393

  Dones, R D ^a   Ruban, L N ^a   Morton, I E ^a   Roberts, S A ^a   English, K M ^b   Channer, K S ^b   Jones, T H ^a,c  

^a UNIVERSITY OF SHEFFIELD   (United Kingdom)

^b ROYAL HALLAMSHIRE HOSPITAL   (United Kingdom)

^c BARNSLEY DISTRICT GENERAL HOSPITAL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

1 [2 (4 METHOXYPHENYL) 2 [3 (4 METHOXYPHENYL)PROPOXY]ETHYL] 1H IMIDAZOLE; CALCIUM; CALCIUM CHANNEL; CALCIUM CHANNEL BLOCKING AGENT; CYCLIC AMP; CYCLIC GMP; CYCLIC NUCLEOTIDE; FLUORESCENT DYE; FORSKOLIN; INDO 1; NIFEDIPINE; NITROPRUSSIDE SODIUM; POTASSIUM CHANNEL; PROSTAGLANDIN F2 ALPHA; TESTOSTERONE; VERAPAMIL;

ANIMAL CELL; AORTA MEDIA; ARTICLE; BIOSYNTHESIS; CALCIUM ANTAGONISM; CALCIUM CELL LEVEL; CARDIOVASCULAR DISEASE; CELL LEVEL; CELL LINE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG MECHANISM; DRUG SENSITIVITY; EVIDENCE BASED MEDICINE; EXTRACELLULAR CALCIUM; FLOW CYTOMETRY; FLUORESCENCE ANALYSIS; GENDER; HORMONE SUBSTITUTION; INCUBATION TIME; NONHUMAN; PRIORITY JOURNAL; RAT; SMOOTH MUSCLE FIBER; STATISTICAL SIGNIFICANCE; VASODILATATION;

ANIMALS; CALCIUM; CALCIUM CHANNEL BLOCKERS; CELL LINE; CHELATING AGENTS; CYCLIC AMP; CYCLIC GMP; DIDEOXYNUCLEOSIDES; DINOPROST; FLOW CYTOMETRY; FORSKOLIN; IMIDAZOLES; INDOLES; INTRACELLULAR FLUID; MUSCLE, SMOOTH, VASCULAR; NIFEDIPINE; NITRIC OXIDE DONORS; NITROPRUSSIDE; TESTOSTERONE; VERAPAMIL;

EID: 0141731255     PISSN: 00220795     EISSN: None     Source Type: Journal    
DOI: 10.1677/joe.0.1780381     Document Type: Article

References (38)

1. Adams JW, Migita DS, Yu MK, Young R, Hellickson MS, Castro-Vargas FE, Domingo JD, Lee PH, Bui JS & Henderson SA 1996 Prostaglandin F2 alpha stimulates hypertrophic growth of cultured neonatal rat ventricular myocytes. Journal of Biological Chemistry 271 1179-1186.
2. 2+ influx via non-genomic surface receptors in activated T cells. FEBS Letters 407 211-214.
3. Benten WP, Lieberherr M, Stamm O, Wrehlke C, Guo Z & Wunderlich F 1999 Testosterone signalling through internalizable surface receptors in androgen receptor-free macrophages. Molecular Biology of the Cell 10 3113-3123.
4. Brewis IA, Morton IE, Mohammad SN, Browes CE & Moore HM 2000 Measurement of intracellular calcium concentration and plasma membrane potential in human spermatozoa using flow cytometry. Journal of Andrology 21 238-249.
5. Chou TM, Sudhir K, Hutchison SJ, Ko E, Amidon TM, Collins P & Chatterjee K 1996 Testosterone induces dilation of canine coronary conductance and resistance arteries in vivo. Circulation 94 2614-2619.
6. 2+ entry mechanisms of coronary vasoconstriction. Arteriosclerosis, Thrombosis and Vascular Biology 19 1034-1040.
7. Deenadayalu VP, White RE, Stallone JN, Gao X & Garcia AJ 2001 Testosterone relaxes coronary arteries by opening the large-conductance, calcium-activated potassium channel. American Journal of Physiology - Heart and Circulatory Physiology 281 H1720-H1727.
8. + channel activation. Journal of Applied Physiology 91 2742-2750.
9. English KM, Steeds RP, Jones TH, Diver MJ & Channer KS 2000 Low-dose transdermal testosterone therapy improves angina threshold in men with chronic stable angina: a randomised, double-blind, placebo-controlled study. Circulation 102 1906-1911.
10. English KM, Jones RD, Jones TH, Morice AH & Channer KS 2001 Gender differences in the vasomotor effects of different steroid hormones in rat pulmonary and coronary arteries. Hormone and Metabolic Research 33 645-652.
11. English KM, Jones RD, Jones TH, Morice AH & Channer KS 2002 Testosterone acts as a coronary vasodilator by a calcium antagonistic action. Journal of Endocrinological Investigation 25 455-458.
12. Gardner JD & Benoit JN 2000 Effects of capacitative calcium entry on agonist-induced calcium transients in A7r5 vascular smooth muscle cells. Journal of Biomedical Science 7 304-310.
13. Griffin BW, Magnino PE, Pang IH & Sharif NA 1998 Pharmacological characterisation of an FP prostaglandin receptor on rat vascular smooth muscle cells (A7r5) coupled to phosphoinositide turnover and intracellular calcium mobilisation. Journal of Pharmacology and Experimental Therapeutics 286 411-418.
14. Honda H, Unemoto T & Kogo H 1999 Different mechanisms for testosterone-induced relaxation of aorta between normotensive and spontaneously hypertensive rats. Hypertension 34 1232-1236.
15. Hughes AD & Schachter M 1994 Multiple pathways for entry of calcium and other divalent cations in a vascular smooth muscle cell line (A7r5). Cell Calcium 15 317-330.
16. 2+ channel blocker LOE 908. British Journal of Pharmacology 126 1107-1114.
17. Jones RD, English KM, Pugh PJ, Morice AH, Jones TH & Channer KS 2002 Pulmonary vasodilatory action of testosterone: evidence of a calcium antagonistic action. Journal of Cardiovascular Pharmacology 39 814-823.
18. Jones RD, Pugh PJ, Hal J, Channer KS & Jones TH 2003a Altered circulating hormone levels, endothelial function and vascular reactivity in the testicular feminised mouse. European Journal of Endocrinology 148 111-120.
19. Jones RD, Pugh PJ, Jones TH & Channer KS 2003b The vasodilatory action of testosterone: a potassium channel opening or a calcium antagonistic action? British Journal of Pharmacology 138 733-744.
20. Lieberherr M & Grosse B 1994 Androgens increase intracellular calcium-concentration and inositol 1,4,5-triphosphate and diacylglycerol formation via a pertussis-toxin-sensitive G-protein. Journal of Biological Chemistry 269 7217-7223.
21. Lyng FM, Jones GR & Rommerts FG 2000 Rapid androgen actions on calcium signalling in rat Sertoli cells and two human prostatic cell lines: similar biphasic responses between 1 picomolar and 100 nanomolar concentrations. Biology of Reproduction 63 736-747.
22. 2+ transport pathways in thymic lymphocytes by econazole, miconazole, and SKF 96365. American Journal of Physiology 264 C654-C662.
23. 2+ entry in A7r5 vascular smooth muscle cells: only the latter operates during receptor activation. Biochemical Journal 362 13-21.
24. (2+)] (i) during inhibition of coronary smooth muscle contraction by 17 beta-estradiol, progesterone, and testosterone. Journal of Pharmacology and Experimental Therapeutics 291 44-52.
25. Nakao J, Chang WC, Murota SI & Orimo H 1981 Oestradiol-binding sites in rat aortic smooth muscle cells in culture. Atherosclerosis 38 75-80.
26. Orimo A, Inoue S, Ikegami A, Hosoi T, Akishita M, Ouchi Y, Muramatsu M & Orimo H 1993 Vascular smooth muscle cells as a target for oestrogen. Biochemical and Biophysical Research Communications 195 730-736.
27. Perusquia M, Hernandez R, Morales MA, Campos MG & Villalon CM 1996 Role of endothelium in the vasodilating effect of progestins and androgens on the rat thoracic aorta. General Pharmacology 27 181-185.
28. Pugh PJ, West JN, Jones TH & Channer KS 2002 Testosterone therapy improves exercise duration and symptoms in men with chronic congestive heart failure. Journal of the American College of Cardiology 39 155A.
29. Pugh PJ, Jones TH & Channer KS 2003 Acute haemodynamic effects of testosterone in men with chronic heart failure. European Heart Journal 24 909-915.
30. Rosano GM, Leonardo F, Pagnotta P, Pelliccia F, Panina G, Cerquetani E, della. Monica P, Bonfigli B, Volpe M & Chierchia SL 1999 Acute anti-ischemic effect of testosterone in men with coronary artery disease. Circulation 99 1666-1670.
31. Scholz H 1997 Pharmacological aspects of calcium channel blockers. Cardiovascular Drugs and Therapy 10 Suppl 3 869-872.
32. Tep-areenan P, Kendall DA & Randall MD 2002 Testosterone-induced vasorelaxation in the rat mesenteric arterial bed is mediated predominantly via potassium channels. British Journal of Pharmacology 135 735-740.
33. Valverde MA, Rojas P, Amigo J, Cosmelli D, Orio P, Bahamonde MI, Mann GE, Vergara C & Latorre R 1999 Acute activation of Maxi-K channels (hSlo) by oestradiol binding to the beta subunit. Science 285 1929-1931.
34. Webb CM, Adamson DL, de Zeigler D & Collins P 1999a Effect of acute testosterone on myocardial ischemia in men with coronary artery disease. American Journal of Cardiology 83 437-439.
35. Webb CM, McNeill JG, Hayward CS, de Zeigler D & Collins P 1999b Effects of testosterone on coronary vasomotor regulation in men with coronary heart disease. Circulation 100 1690-1696.
36. White MM, Zamudio S, Stevens T, Tyler R, Lindenfeld J, Leslie K & Moore LG 1995 Oestrogen, progesterone and vascular reactivity: potential cellular mechanisms. Endocrine Reviews 16 739-751.
37. Wu SZ & Weng XZ 1993 Therapeutic effects of an androgenic preparation on myocardial ischemia and cardiac function in 62 elderly male coronary heart disease patients. Chinese Medical Journal 106 415-418.
38. Yue P, Chatterjee K, Beale C, Poole-Wilson PA & Collins P 1995 Testosterone relaxes rabbit coronary arteries and aorta. Circulation 91 1154-1160.