Proton Pump Inhibitors Control Osteoclastic Resorption of Calcium Phosphate Implants and Stimulate Increased Local Reparative Bone Growth

Journal of Craniofacial Surgery

Volumn 14, Issue 3, 2003, Pages 301-307

  Rzeszutek, K ^a   Sarraf, F ^a   Davies, J E ^a  

^a UNIVERSITY OF TORONTO   (Canada)

Author keywords

Controlled resorption; Increased local bone mass; Osteoclast proton pump inhibitor; Resorbable calcium phosphates

Indexed keywords

ANTIINFECTIVE AGENT; BAFILOMYCIN A1; BONE CEMENT; CALCIUM PHOSPHATE; ENZYME INHIBITOR; MACROLIDE; PROTON TRANSPORTING ADENOSINE TRIPHOSPHATASE;

ANIMAL; ARTICLE; BIODEGRADABLE IMPLANT; BONE DENSITY; BONE PROSTHESIS; BONE REGENERATION; DRUG ANTAGONISM; DRUG EFFECT; MALE; METABOLISM; OSTEOCLAST; OSTEOLYSIS; RAT; WISTAR RAT;

ABSORBABLE IMPLANTS; ANIMALS; ANTI-BACTERIAL AGENTS; BONE CEMENTS; BONE DENSITY; BONE RESORPTION; BONE SUBSTITUTES; CALCIUM PHOSPHATES; ENZYME INHIBITORS; MACROLIDES; MALE; OSSEOINTEGRATION; OSTEOCLASTS; PROTON-TRANSLOCATING ATPASES; RATS; RATS, WISTAR;

EID: 0141725701     PISSN: 10492275     EISSN: 15363732     Source Type: Journal    
DOI: 10.1097/00001665-200305000-00007     Document Type: Article

References (21)

1. Brown W, Chow LC. Combinations of sparingly soluble calcium phosphates in slurries and paste as mineralizers and cements. US patent number 4612053
2. Takagi S, Chow LC, Ishikawa K. Formation of hydroxyapatite in new calcium phosphate cements. Biomaterials 1998; 19:1593-1599
3. Frayssinet P, Roudier M, Lerch A, et al. Tissue reaction against a self-setting calcium phosphate cement set in bone or outside the organism. J Mat Sci Mater Med 2000; 11:811-815
4. Miyamoto Y, Ishikawa K, Takechi M, et al. Tissue response to fast-setting calcium phosphate cement in bone. J Biomed Mater Res 1997; 37:457-464
5. Ohura K, Bohner M, Hardouin P, et al. Resorption of, and bone formation from, new beta-tricalcium phosphate-monocalcium phosphate cements: an in vivo study. J Biomed Mater Res 1996; 30:193-200
6. Clokie CM, Moghadam H, Jackson MT, et al. Closure of critical sized defects with allogenic and alloplastic bone substitutes. J Craniofac Surg 2002; 13:111-123
7. +)-ATPases. Proc Natl Acad Sci USA 1992; 89:6257-6261
8. +)-ATPases. J Exp Biol 1992; 172:193-204
9. Farina C, Gagliardi S. Selective inhibitors of the osteoclast vacuolar proton ATPase as novel bone antiresorptive agents. Drug Discov Today 1999; 4:163-172
10. Gagliardi S, Gatti PA, Belfiore P, et al. Synthesis and structure—activity relationships of Bafilomycin A1 derivatives as inhibitors of vacuolar H+-ATPase. J Med Chem 1998; 41:1883-1893
11. Bowman BJ, Bowman EJ. Mutations in subunit c of the vacuolar ATPase confer resistance to Bafilomycin and identify a conserved antibiotic binding site. J Biol Chem 2002: 277:3965-3972
12. Mattson JP, Keeling DJ. [3H] Bafilomycin as a probe for the transmembrane proton channel of the osteoclast vacuolar H(+)-ATPase. Biochim Biophys Acta 1996; 1280:98-106
13. 1 abolishes bone resorption. Biochem Biophys Res Commun 1990; 16:168
14. 1 in bone resorption and tooth eruption in dogs. Eur J Oral Sci 1995; 103:231-235
15. Bohner M, Lemaitre J, Van Landuyt P, et al. Gentamycin-loaded hydraulic calcium phosphate bone cement as antibiotic delivery system. J Pharm Sci 1997; 86:565-572
16. Hamanishi C, Kitamoto K, Tanaka S, et al. A self-setting TTCP-DCPD apatite cement for release of vancomycin. J Biomed Mater Res 1996; 33:139-143
17. Nies B. Process for producing bone cement containing active substances. US patent number 6160033
18. Poser R, Fulmer M, Constantz BR. Calcium phosphate cements comprising antimicrobial agents. US patent number 5968253
19. Miyamoto Y, Fukao H, Sawada M, et al. In vivo setting behavior of fast-setting calcium phosphate cement. Biomaterials 1995; 16:855-860
20. 1 inhibits bone resorption and tooth eruption in vivo. J Bone Miner Res 1994; 9:1575-1582
21. 1. Connect Tissue Res 1995; 32:159-163