Selective inhibitors of the osteoclast vacuolar proton ATPase as novel bone antiresorptive agents

Drug Discovery Today

Volumn 4, Issue 4, 1999, Pages 163-172

  Farina, Carlo ^a   Gagliardi, Stefania ^a  

^a SmithKline Beecham   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 0001405992     PISSN: 13596446     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1359-6446(99)01321-5     Document Type: Review

References (85)

1. Consensus Development Conference: Prophylaxis and Treatment of Osteoporosis (1993) Am. J. Med. 94, 646-650
2. Baron, R. et al. (1985) J. Cell Biol. 101, 2210-2222
3. Drake, F. et al. (1996) J. Biol. Chem. 271, 12511-12516
4. Gelb, B.D. et al. (1996) Science273, 1236-1238
5. Blair, H.C. et al. (1989) Science 245, 855-857
6. Laitala, T. and Väänänen, H.K. (1993) J. Bone Miner. Res. 8, 119-126
7. Laitala, T. and Väänänen, H.K. (1994) J. Clin. Invest. 93, 2311-2318
8. Mellman, I. (1992) J. Exp. Biol. 172, 39-45
9. Brown, M.S., Anderson, R.G. and Goldstein, J.L. (1983) Cell 32, 663-667
10. Finbow, M.E. and Harrison, MA. (1997) Biochem. J. 324, 697-712
11. Forgac, M. (1996) Soc. Gen. Physiol. Ser. 51, 121-132
12. Abrahams, J.P. et al. (1994) Nature 370, 621-628
13. Noji, H. et al. (1997) Nature 386, 299-302
14. Harrison, M.A., Finbow, M.E. and Findlay, J.B.C. (1997) Mol. Membr. Biol. 14, 1-3
15. Gluck, S. and Caldwell, J. (1987) J. Biol. Chem. 262, 15780-15789
16. Randall, S.K. and Sze, H. (1987) J. Biol. Chem. 262, 7135-7141
17. Arai, H. et al. (1988) J. Biol. Chem. 263, 8796-8802
18. Lee, B.S. et al. (1996) Am. J. Physiol. 270, C382-C388
19. Mattsson, J.P. et al. (1997) J. Bone Miner. Res. 12, 753-760
20. Van Hille, B. et al. (1993) Biochem. Biophys. Res. Commun. 197, 15-21
21. Hernando, N. et al. (1995) Proc. Natl. Acad. Sci. U. S. A. 92, 6087-6091
22. Van Hille, B. et al. (1993) J. Biol Chem. 268, 7075-7080
23. Li, Y.P., Chen, W. and Stashenko, P. (1996) Biochem. Biophys. Res. Commun. 218, 813-821
24. Scott, B.B. and Chapman, C.G. (1998) Eur. J. Pharmacol. 346, R3-R4
25. Van Hille, B. et al. (1995) Biochem. Biophys. Res. Commun. 214, 1108-1113
26. Chatterjee, D. et al. (1992) Proc. Natl. Acad. Sci. U. S. A. 89, 6257-6261
27. Chatterjee, D. et al. (1993) Biochemistry 32, 2808-2812
28. Mattsson, J.P. et al. (1993) Biochem. Biophys. Acta 1146, 106-112
29. Mattsson, J.P. et al. (1994) J. Biol. Chem. 269, 24979-24982
30. Hall, T.J. and Schaueblin, M. (1994) Bone Miner. 27, 159-166
31. Taiz, L. et al. (1994) Biochem. Biophys. Acta 1194, 329-334
32. Hunt, I.E. et al. (1996) Plant Physiol. 110, 97-103
33. Uchida, E., Ohsumi, Y. and Anraku, Y. (1988) J. Biol. Chem. 263, 45-51
34. Tuukanen, J. and Väänänen, H.K. (1986) Calcif. Tissue Int. 38, 123-125
35. Mizunashi, K. et al. (1993) Calcif. Tissue Int. 53, 21-25
36. Finbow, M.E. et al. (1992) Protein Eng. 5, 7-15
37. Apps, D.K. and Webster, L.C. (1996) Biochem. Biophys. Res. Commun. 227, 839-845
38. Hughes, G. et al. (1996) Biochem. J. 317, 425-431
39. Blair, H.C. et al. (1992) J Cell. Biochem. 48, 401-410
40. Schlesinger, P.H. et al. (1998) Bone 23 (Suppl. 5), S157
41. Kataoka, T. et al. (1995) FEBS Lett. 359, 53-59
42. Sato, T. et al. (1998) J. Biol. Chem. 273, 21455-21462
43. Bowman, E.M., Siebers, A. and Altendorf, K. (1988) Proc. Natl. Acad. Sci. U. S. A. 85, 7972-7976
44. Drose, S. et al. (1993) Biochemistry 32, 3902-3906
45. Zhang, J., Feng, Y. and Forgac, M. (1994) J. Biol. Chem. 269, 23518-23523
46. Sundquist, K. et al. (1990) Biochem. Biophys. Res. Commun. 168, 309-313
47. Farina, C. et al. (1995) J. Bone Miner. Res. 10 (Suppl. 1), S225
48. Ryberg, B. et al. (1996) J. Bone Miner. Res. 11 (Suppl. 1), S399
49. Kodayra, Y. (1961) Agric. Biol. Chem. 25, 261-263
50. Muroi, M., Shiragami, N. and Takatsuki, A. (1994) Biochem. Biophys. Res. Commun. 205, 1358-1365
51. Nordström, T. et al. (1994) FEBS Lett. 350, 82-86
52. Hoehn-Thierry, P. et al. (1995) WO Patent Appl. 95/00520
53. Fleisch, H. (1997) Medicina (Buenos Aires) 57 (Suppl. 1), 65-75
54. David, P. et al. (1996) J. Bone Miner. Res. 11, 1498-1507
55. Belfiore, P. et al. (1997) J. Bone Miner. Res. 12 (Suppl. 1), S345
56. Nomoto, T. (1996) JP Patent Appl. 8143525
57. Oku, T. et al. (1997) WO Patent Appl. 97/14681
58. Sarges, R. et al. (1994) US Patent 5362743
59. Fabricant, C. et al. (1993) J. Bone Miner. Res. 8 (Suppl. 1), S392
60. Corbett, J.W. et al. (1997) Med. Chem. Res. 7, 151-167
61. Bergman, R. et al. (1997) WO Patent Appl 97/23475
62. Hanessian, S. et al. (1996) Tetrahedron Lett. 37, 9001-9004
63. Mattson, J.P. et al. (1997) J. Bone Miner. Res. 12 (Suppl. 1), S287
64. Keeling, D.J. et al. (1998) Acta Physiol. Scand. 163, 195-201
65. Herslöf, M. et al. (1997) J. Bone Miner. Res. 12 (Suppl. 1), S195
66. Gagliardi, S. et al. (1998) J. Med. Chem. 41, 1883-1893
67. Gatti, P.A. et al. (1996) J. Org. Chem. 61, 7185-7188
68. Gagliardi, S. et al. (1997) Tetrahedron Lett. 38, 479-482
69. Gatti, P.A. et al. (1997) Tetrahedron Lett. 38, 6949-6952
70. Gagliardi, S. et al. (1998) J. Med. Chem. 41, 1568-1573
71. Votta, B.J. et al. (1997) J. Bone Miner. Res. 12, 1396-1405
72. Nadler, G. et al. (1998) Bioorg. Med. Chem. 8, 3621-3626
73. Dodds, R.A. et al. (1997) J. Bone Miner. Res. 12 (Suppl. 1), S193
74. Visentin, L. et al. (1998) Bone 23 (Suppl. 5), S181
75. Martinez-Zagulian, R. et al. (1993) Am. J. Physiol. 265 (4 Pt 1), C1015-C1029
76. Manabe, T. et al. (1993) J Cell Physiol. 157, 445-452
77. Kinoshita, K., Hidaka, H. and Ohkuma, S. (1994) FEBS Lett. 337, 221-225
78. Holt, T. et al. (1993) WO Patent Appl. 93/18652
79. Holt, T. et al. (1993) WO Patent Appl. 93/18653
80. Kinoshita, K. et al. (1996) FEBS Lett. 398, 61-66
81. Gottlieb, R.A. et al. (1995) Proc. Natl. Acad. Sci. U. S. A. 92, 5965-5968
82. Ohta, T. et al. (1998) J. Pathol. 185, 324-330
83. Knops, J. et al. (1995) J. Biol. Chem. 270, 2419-2422
84. Haass, C. et al. (1995) J. Biol. Chem. 270, 6186-6192
85. Wax, M.B. et al. (1997) Proc. Natl. Acad. Sci. U. S. A. 94, 6752-6757